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Topic Review
Biomedical Alloys and Physical Surface Modifications
Biomedical alloys are essential parts of modern biomedical applications. However, they cannot satisfy the increasing requirements for large-scale production owing to the degradation of metals. Physical surface modification could be an effective way to enhance their biofunctionality.
  • 467
  • 11 Jan 2022
Topic Review
Biomedical Application of Carbon Dots
Carbon dots (CDs), which are a new category of carbon nanoparticles that consist of quasi-spherical, discrete fluorescent carbon nanomaterials with a diameter of less than 10 nm, have multiple advantages over semiconductor quantum dots (QDs), including high water solubility, low cost, excellent biocompatibility, chemically inertness, highly tunable photoluminescence and electrochemical luminescence. Because of their unique properties, carbon quantum dots (CQDs) have acquired significance in nano-chemistry, which has resulted in the discovery of CDD applications, especially in biomedical applications.            
  • 649
  • 01 Mar 2023
Topic Review
Biomedical Application of Silk-Based Cryogels
There is a need to develop the next generation of medical products that require biomaterials with improved properties. The versatility of various gels has pushed them to the forefront of biomaterials research. Cryogels, a type of gel scaffold made by controlled crosslinking under subzero or freezing temperatures, have great potential to address many current challenges. Unlike their hydrogel counterparts, which are also able to hold large amounts of biologically relevant fluids such as water, cryogels are often characterized by highly dense and crosslinked polymer walls, macroporous structures, and often improved properties. 
  • 474
  • 04 Jan 2023
Topic Review
Biomedical Applications of Antiviral Nanohybrids
The COVID-19 pandemic has driven a global research to uncover novel, effective therapeutical and diagnosis approaches. In addition, control of spread of infection has been targeted through development of preventive tools and measures. In this regard, nanomaterials, particularly, those combining two or even several constituting materials possessing dissimilar physicochemical (or even biological) properties, i.e., nanohybrid materials play a significant role. Nanoparticulate nanohybrids have gained a widespread reputation for prevention of viral crises, thanks to their promising antimicrobial properties as well as their potential to act as a carrier for vaccines. On the other hand, they can perform well as a photo-driven killer for viruses when they release reactive oxygen species (ROS) or photothermally damage the virus membrane. The nanofibers can also play a crucial protective role when integrated into face masks and personal protective equipment, particularly as hybridized with antiviral nanoparticles.
  • 585
  • 16 Sep 2021
Topic Review
Biomedical Applications of Bimetallic Coordination Polymers
Bimetallic coordination polymers (CPs) have two different metal ions as connecting nodes in their polymer structure. The synthesis methods of bimetallic CPs are mainly categorized into the one-pot method and post-synthesis modifications according to various needs. Compared with monometallic CPs, bimetallic CPs have synergistic effects and excellent properties, such as higher gas adsorption rate, more efficient catalytic properties, stronger luminescent properties, and more stable loading platforms, which have been widely applied in the fields of gas adsorption, catalysis, energy storage as well as conversion, and biosensing.
  • 142
  • 06 Mar 2024
Topic Review
Biomedical Applications of Bio-inspired Nanomaterials in Micro/Nanodevices
Exploring bio-inspired nanomaterials (BINMs) and incorporating them into micro/nanodevices represent a significant development in biomedical applications. Nanomaterials, engineered to imitate biological structures and processes, exhibit distinctive attributes such as exceptional biocompatibility, multifunctionality, and unparalleled versatility. The utilization of BINMs demonstrates significant potential in diverse domains of biomedical micro/nanodevices, encompassing biosensors, targeted drug delivery systems, and advanced tissue engineering constructs. 
  • 585
  • 28 Sep 2023
Topic Review
Biomedical Applications of Calcium Orthophosphate (CaPO4)-Based Bioceramics
A strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. Current biomedical applications of CaPO4-based bioceramics include artificial bone grafts, bone augmentations, maxillofacial reconstruction, spinal fusion, and periodontal disease repairs, as well as bone fillers after tumor surgery.
  • 430
  • 10 Jul 2023
Topic Review
Biomedical Applications of CaPO4 Deposits
The clinical applications of CaPO4 alone were largely limited to non-load-bearing areas of the body. However, investigations have continued and researchers have begun to deposit biocompatible CaPO4 on the surface of mechanically strong but biologically inert or biotoxic materials in order to combine the benefits of various materials. For example, metal implants are used in artificial joints such as hip joints and artificial tooth roots as sufficient mechanical stability is required.  Since no metal alone causes osseointegration, i.e., they do not create a mechanically stable connection between the implant and bone tissue, they are coated with CaPO4 to create osseointegration. However, the problem of osseointegration is not limited to metals. Biodegradable polymers are also generally not bioactive. Therefore, to overcome this disadvantage, the surface of those polymers is also coated with CaPO4 and can be replaced by autogenous bone after implantation, as CaPO4 is involved in the same bone regeneration response as natural bones.
  • 272
  • 07 Jul 2023
Topic Review
Biomedical Applications of Chitosan
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications.
  • 215
  • 05 Jul 2023
Topic Review
Biomedical Applications of Electrospun Graphene Oxide
Graphene is an allotrope of carbon and is made up of sp2-bonded carbon atoms placed in a two-dimensional honeycomb lattice. Graphite consists of stacked layers of graphene. Due to the distinctive structural features as well as excellent physico-chemical and electrical conductivity, graphene allows remarkable improvement in the performance of electrospun nanofibers (NFs), which results in the enhancement of promising applications in NF-based sensor and biomedical technologies. 
  • 447
  • 22 Nov 2022
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