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Topic Review
Cell-Surface Interactions on Arginine-Rich CPPs Allow for Internalization
Cellular uptake of biologically active molecules is a significant obstacle to developing drug design and controlled drug delivery. For instance, it is hard for the monoclonal antibodies to penetrate the cell membrane and enter the cell due to their large molecular weight. Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic acids, and macromolecules to permeate cell membranes, creating a novel route for exogenous substances to enter cells.
  • 415
  • 24 Aug 2022
Topic Review
Volatilomics in Prostate Cancer
The lack of highly specific and sensitive biomarkers for the early detection of prostate cancer (PCa) is a major barrier to its management. Volatilomics emerged as a non-invasive, simple, inexpensive, and easy-to-use approach for cancer screening, characterization of disease progression, and follow-up of the treatment’s success.
  • 550
  • 24 Aug 2022
Topic Review
Magnetic Drug-Delivery System
Magnetic nanoparticles (MNPs) are nanoscale particles (1–100 nm) that can be guided through an external magnetic field due to their superparamagnetic, ferrimagnetic, and ferromagnetic properties, which may provide features for biomedical applications. 
  • 503
  • 23 Aug 2022
Topic Review
Effects of Micro-/Nanorobots on Various Microbial Species
One of the most pressing concerns to global public health is the emergence of drug-resistant pathogenic microorganisms due to increased unconscious antibiotic usage. With the rising antibiotic resistance, existing antimicrobial agents lose their effectiveness over time. This indicates that newer and more effective antimicrobial agents and methods should be investigated. 
  • 470
  • 23 Aug 2022
Topic Review
Graphene Oxide Action Mechanisms
Graphene oxide (GO), an oxidized form of graphene, is regarded to be more superior to graphene with regards to application in drug delivery due to the presence of functional groups that could allow the binding of different compounds, especially water-insoluble drugs. 
  • 569
  • 23 Aug 2022
Topic Review
Classification of Biomaterials Used in Delivery Systems
A delivery system generally utilizes biomaterials as carriers to embed, deliver, and release bioactive substances at the desired site under controlled conditions. Among them, inorganic and organic biomaterials are popular in delivery system-based regenerative medicine.
  • 366
  • 23 Aug 2022
Topic Review
Optically Transparent Bamboo
As environmental concerns and the desire to establish a sustainable civilization become more urgent, bamboo has been identified as a potential replacement for materials based on non-renewable resources. There are about 1500 species of bamboo and 36 million hectares of bamboo planting area widely distributed across America, Asia, and Africa. Indeed, bamboo is an important forest resource, having a higher yield, more rapid growth rate, and better mechanical properties than wood, as well as a high aspect ratio and excellent biodegradability. In terms of growth rate, bamboo has a short growth cycle of 3–5 years, whereas wood has a growth cycle of 20–60 years. Furthermore, single bamboo fiber has average tensile strength and modulus of 1.6 GPa and 33 GPa, respectively, which is significantly higher than other known natural fibers, such as cotton, coir, henequen, and ramie. Bamboo has been widely used to fabricate various structural composites, including bamboo scrimber composites, laminated bamboo lumber, and bamboo-fiber-reinforced epoxy composites.
  • 391
  • 23 Aug 2022
Topic Review
Silica Nanoparticles
Silica nanoparticles (NPs) can be categorized into two main groups: solid (non-porous) silica NPs and porous silica NPs. The latter can be further subdivided according to the size of their pores, being mesoporous silica nanoparticles (MSNs) the most studied category among porous silica NPs. 
  • 704
  • 23 Aug 2022
Topic Review
Polyamine Detection Methods
The biogenic aliphatic polyamines (spermine, spermidine, and putrescine) are responsible for numerous cell functions, including cell proliferation, the stabilization of nucleic acid conformations, cell division, homeostasis, gene expression, and protein synthesis in living organisms. The change of polyamine concentrations in the urine or blood is usually related to the presence of malignant tumors and is regarded as a biomarker for the early diagnosis of cancer. Therefore, the detection of polyamine levels in physiological fluids can provide valuable information in terms of cancer diagnosis and in monitoring therapeutic effects. 
  • 1.0K
  • 23 Aug 2022
Topic Review
Paper-Based Enzymatic Electrochemical Sensors for Glucose Determination
The general objective of Analytical Chemistry is to obtain best-quality information in the shortest time to contribute to the resolution of real problems. In this regard, electrochemical biosensors are interesting alternatives to conventional methods thanks to their great characteristics, both those intrinsically analytical (precision, sensitivity, selectivity, etc.) and those more related to productivity (simplicity, low costs, and fast response, among others). The scientific community has made continuous progress in improving glucose biosensors, being this analyte the most important in the biosensor market, due to the large amount of people who suffer from diabetes mellitus. The sensitivity of the electrochemical techniques combined with the selectivity of the enzymatic methodologies have positioned electrochemical enzymatic sensors as the first option.
  • 538
  • 23 Aug 2022
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