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Topic Review
Nanoparticle–Biomolecule Conjugate
A nanoparticle–biomolecule conjugate is a nanoparticle with biomolecules attached to its surface. Nanoparticles are minuscule particles, typically measured in nanometers (nm), that are used in nanobiotechnology to explore the functions of biomolecules. Properties of the ultrafine particles are characterized by the components on their surfaces more so than larger structures, such as cells, due to large surface area-to-volume ratios. Large surface area-to-volume-ratios of nanoparticles optimize the potential for interactions with biomolecules.
  • 569
  • 30 Nov 2022
Topic Review
Orgasm
Orgasm (from Greek ὀργασμός, orgasmos; "excitement, swelling") or sexual climax is the sudden discharge of accumulated sexual excitement during the sexual response cycle, resulting in rhythmic, involuntary muscular contractions in the pelvic region characterized by sexual pleasure. Experienced by males and females, orgasms are controlled by the involuntary or autonomic nervous system. They are usually associated with involuntary actions, including muscular spasms in multiple areas of the body, a general euphoric sensation and, frequently, body movements and vocalizations. The period after orgasm (known as the refractory period) is typically a relaxing experience, attributed to the release of the neurohormones oxytocin and prolactin as well as endorphins (or "endogenous morphine"). Human orgasms usually result from physical sexual stimulation of the penis in males (typically accompanying ejaculation) and of the clitoris in females. Sexual stimulation can be by self-practice (masturbation) or with a sex partner (penetrative sex, non-penetrative sex, or other sexual activity). The health effects surrounding the human orgasm are diverse. There are many physiological responses during sexual activity, including a relaxed state created by prolactin, as well as changes in the central nervous system such as a temporary decrease in the metabolic activity of large parts of the cerebral cortex while there is no change or increased metabolic activity in the limbic (i.e., "bordering") areas of the brain. There is also a wide range of sexual dysfunctions, such as anorgasmia. These effects affect cultural views of orgasm, such as the beliefs that orgasm and the frequency or consistency of it are either important or irrelevant for satisfaction in a sexual relationship, and theories about the biological and evolutionary functions of orgasm.
  • 3.0K
  • 30 Nov 2022
Topic Review
MAb114
mAb114 is a monoclonal antibody that is being evaluated as a treatment for Ebola virus disease. Its discovery was led by the laboratory of Nancy Sullivan at the United States National Institute of Health Vaccine Research Center and J. J. Muyembe-Tamfum from the Institut National pour la Recherche Biomedicale (INRB) in the Democratic Republic of Congo, working in collaboration with the Institute of Biomedical Research and the United States Army Medical Research Institute of Infectious Diseases. mAb114 was isolated from the blood of a survivor of the 1995 outbreak of Ebola virus disease in Kikwit, Democratic Republic of Congo roughly ten years later. In early 2018, a Phase 1 clinical trial of mAb114 was conducted by Martin Gaudinski within the Vaccine Research Center Clinical Trials Program that is led by Julie E. Ledgerwood. mAb114 is also being evaluated during the 2018 North Kivu Ebola outbreak. mAb114 has also shown success with lowering the mortality rate from ~70% to about 34%. In August 2019, Congolese health authorities, the World Health Organization, and the U.S. National Institutes of Health promoted the use of mAb114, alongside REGN-EB3, a similar Regeneron-produced monoclonal antibody treatment, over other treatments yielding higher mortality rates, after ending clinical trials during the outbreak.
  • 479
  • 30 Nov 2022
Topic Review
Mazer (Drinking Vessel)
A mazer is a special type of wooden drinking vessel, a wide cup or shallow bowl without handles, with a broad flat foot and a knob or boss in the centre of the inside, known technically as the print or boss. They vary from simple wood pieces all in wood to those ornamented with metalwork, often in silver or silver-gilt. They use dense impervious woods such as maple, beech and walnut wood, and get their name from the spotted or birdseye marking on the wood (Ger. Maser, spot, marking, especially on wood; cf. "measles"), or possibly maserle as a name for Acer campestre. They are a north European medieval tradition, mostly made from the 11th (or earlier) to the 16th centuries.
  • 545
  • 30 Nov 2022
Topic Review
Bivalent Proximity-Inducing Compounds for Targeted Protein Degradation
Bivalent proximity-inducing compounds represent a novel class of small molecule therapeutics with exciting potential and new challenges. The most prominent examples of such compounds are utilized in targeted protein degradation where E3 ligases are hijacked to recruit a substrate protein to the proteasome via ubiquitination.
  • 778
  • 30 Nov 2022
Topic Review
Peptidomimetics and Their Applications for Opioid Peptide Drug
Peptidomimetics are synthetically altered peptides with adjusted molecular properties for specific biological or therapeutic applications and have been an important class of drug molecules due to their potential features, high potency, and low toxicity since the term was created first in the late 1970s.
  • 478
  • 30 Nov 2022
Topic Review
Deferoxamine-Based Materials and Sensors for Fe(III) Detection
Deferoxamine (DFO) is a siderophore widely studied for its ability to bind iron(III) strongly. Thanks to its versatility, it is suitable for several clinical and analytical applications, from the recognized iron(III) chelation therapy to the most recent applications in sensing. The presence of three hydroxamic functional groups enables Deferoxamine to form stable complexes with iron(III) and other divalent and trivalent metal ions. Moreover, the terminal amino group in the DFO molecule, not involved in metal ion complexation, allows modification or functionalization of solid phases, nanoobjects, biopolymers, electrodes and optical devices.
  • 422
  • 30 Nov 2022
Topic Review
Plastic Waste Upcycling Approaches
Plastic waste pollution, including non-biodegradable landfills, leaching of toxic chemicals into soil and waterways, and emission of toxic gases into the atmosphere, is significantly affecting our environment. Conventional plastic waste recycling approaches generally produce lower-value materials compared to the original plastic or recover inefficient heat energy. Lately, upcycling or the valorization approach has emerged as a sustainable solution to transform plastic waste into value-added products.
  • 532
  • 30 Nov 2022
Topic Review
Bioremediation of PCBs
PCB, polychorinated biphenyls, are a type of chemical that was widely used in the 1960s and 1970s, and which is a contamination source of soil and water. They are fairly stable and therefore persistent in the environment. Bioremediation of PCBs is the use of microorganisms to degrade PCBs from contaminated sites, which can be either a soil or aqueous environment. It is a process relying on multiple microorganisms' co-metabolism. Anaerobic microorganisms dechlorinate PCBs first, and other microorganisms that are capable of doing BH pathway can break down the dechlorinated PCBs to usable intermediates like acyl-CoA or carbon dioxide. If no BH pathway-caple microorganisms are present, dechlorinated PCBs can be mineralized with help of fungi and plants. However, there are multiple limiting factors for this co-metabolism.
  • 758
  • 29 Nov 2022
Topic Review
General Synthesis Methods of Poly (ε-caprolactone)-Based Graft Copolymers
Synthetic biopolymers are attractive alternatives to biobased polymers, especially because they rarely induce an immune response in a living organism. Poly ε-caprolactone (PCL) is a well-known synthetic aliphatic polyester universally used for many applications, including biomedical and environmental ones.  To expand the range of applications for PCL, researchers have investigated the possibility of grafting polymer chains onto the PCL backbone. As the PCL backbone is not functionalized, it must be first functionalized in order to be able to graft reactive groups onto the PCL chain. These reactive groups will then allow the grafting of new reagents and especially new polymer chains. Grafting of polymer chains is mainly carried out by “grafting from” or “grafting onto” methods.
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