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Topic Review
Natural Product Extraction Techniques
Conventional extraction techniques, including Soxhlet extraction, maceration, percolation, and decoction, are known to be time-, solvent-, and energy-intensive. In contrast, various non-conventional techniques for the extraction process, such as supercritical fluid extraction (SFE), microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE), have been developed to increase the yield of bioactive compounds and address the aforementioned issues. These contemporary techniques have demonstrated their sustainability compared to conventional ones. Low-temperature and environmentally friendly extraction techniques have gained popularity for producing high-quality bioactive extracts. UAE, in particular, has attracted considerable interest due to its advantages over conventional extraction methods, which include greater extraction efficiency, preservation of bioactive compound stability, shorter extraction time, and industrial application. Thus, non-conventional extraction techniques like SFE, MAE, and UAE offer sustainable and efficient alternatives to conventional methods, allowing for increased bioactive compound yield, shorter extraction times, and improved stability, making them popular choices for high-quality extraction in low-temperature and environmentally friendly approaches.
  • 887
  • 05 Jul 2023
Topic Review
Biomedical Applications of Chitosan
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications.
  • 230
  • 05 Jul 2023
Topic Review
Synthesis and Properties of Deep Eutectic Solvents
The use of deep eutectic solvents (DES) is on the rise worldwide because of the astounding properties they offer, such as simplicity of synthesis and utilization, low-cost, and environmental friendliness, which can, without a doubt, replace conventional solvents used in heaps.
  • 719
  • 04 Jul 2023
Topic Review
Applications of Polymeric Materials with Antibacterial Properties
The presence of antibiotic-resistant bacteria in people's environment is a matter of growing concern. The issue of multidrug-resistant bacteria urged the need to elaborate the novel antipathogen agents. The polymers and copolymers modified with bioactive compounds have emerged as a group of highly effective antimicrobial agents that find usage in many fields. The natural polymers have a great advantage over the synthetic ones due to their non-toxicity, biocompatibility, non-immunogenicity, and high stability. On the other hand, they are less effective in biomedical applications in comparison to synthetic polymers. The modifications that provide the natural polymers with desirable industrial activity include chemical treatment processes such as hydroxylation, carboxylation and epoxidation, or in vitro enzyme treatment.
  • 393
  • 04 Jul 2023
Topic Review
Natural Superhydrophobic Surfaces and Wetting Regimes
In nature, many kinds of plants and animals have superhydrophobic surfaces, attracting extensive attention due to their unique properties, such as self-cleaning, water-proofing, uniaxial water transport, etc. Although the apparent contact angles (CAs) of these surfaces are similar, the CAHs may be different considering the chemical compositions of these surfaces. Additionally, the important “lotus leaf effect” and “rose petal effect” are proposed according to the water repellency/adhesion.
  • 268
  • 04 Jul 2023
Topic Review
Solid-Phase Extraction/Pre-Concentration Strategies for Drug Analysis
Despite the fact that strong routine separation methodologies can give reliable specificity and validity at usual working pharmaceutical concentrations, they may fail at very low concentration levels. This poses considerable challenges for researchers investigating product purity and therapeutic drug monitoring. Sensitivity enhancement procedures are thus required to maximize the performance of separation techniques. Solid-phase extraction/solid-phase enrichment (SPE/SPEn) and pre-, post-, and in-column derivatization, as well as the use of sensitive detection devices, are the simplest strategies for improving sensitivity of separation-based analytical techniques. Large-volume injection of samples with online SPE/SPEn coupled with separation techniques increased sensitivity and improved detection as well as quantification limits without affecting peak shape and system performance. 
  • 313
  • 04 Jul 2023
Topic Review
Application of Electrochemical Food Monitoring for Food Additives
Lectrochemical sensors (ECSs) is a powerful method with great sensitivity and reliability for food evaluation. Metal-organic frameworks (MOFs) with surprisingly porous morphology provide uniform yet tunable features, a high specific surface, and established practical applications in various fields. MOF-based ECSs present novel routes for the fast and effective detection of food contaminants or nutrients. 
  • 245
  • 04 Jul 2023
Topic Review
Potentiometry and Ion-Selective Electrodes
Potentiometry is a highly selective and relatively cheap method that allows achieving low detection limits and a very wide dynamic range of sensors (up to eight orders of units). The principle of the method is to measure the electromotive force (EMF) of a cell made of two types of electrodes: a reference electrode whose potential has to necessarily be constant regardless of the composition and concentration of the sample, and an indicator (working) electrode whose potential changes depending on the activity of the main ion present in the sample solution to which the ion-selective membrane is sensitive.
  • 523
  • 04 Jul 2023
Topic Review
Metabolite-Based Hydrogels
Minimalistic peptide- and metabolite-based supramolecular hydrogels have great potential relative to traditional polymeric hydrogels in various biomedical and technological applications. Advantages such as remarkable biodegradability, high water content, favorable mechanical properties, biocompatibility, self-healing, synthetic feasibility, low cost, easy design, biological function, remarkable injectability, and multi-responsiveness to external stimuli make supramolecular hydrogels promising candidates for drug delivery, tissue engineering, tissue regeneration, and wound healing. Non-covalent interactions such as hydrogen bonding, hydrophobic interactions, electrostatic interactions, and π–π stacking interactions play key roles in the formation of peptide- and metabolite-containing low-molecular-weight hydrogels. Peptide- and metabolite-based hydrogels display shear-thinning and immediate recovery behavior due to the involvement of weak non-covalent interactions, making them supreme models for the delivery of drug molecules. In the areas of regenerative medicine, tissue engineering, pre-clinical evaluation, and numerous other biomedical applications, peptide- and metabolite-based hydrogelators with rationally designed architectures have intriguing uses. 
  • 528
  • 03 Jul 2023
Topic Review
N-Doped Graphene and Derivatives as Resistive Gas Sensors
Graphene and its derivatives with a 2D structure are among the most encouraging materials for gas-sensing purposes, because a 2D lattice with high surface area can maximize the interaction between the surface and gas, and a small variation in the carrier concentration of graphene can cause a notable modulation of electrical conductivity in graphene. Furthermore, graphene has a high mobility of electrons and good conductivity.
  • 319
  • 03 Jul 2023
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