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Topic Review
Diagnosis of Enamel Cracks
Cracked teeth can pose a diagnostic dilemma for a clinician as they can mimic several other conditions. The constant physiological stress along with any pathological strain like trauma or iatrogenic causes can lead to the development of microcracks in the teeth. Constant exposure to immense stress can cause the progression of these often-undiagnosed tooth cracks to cause tooth fractures. 
  • 777
  • 07 Sep 2022
Topic Review
Food Choice Editing in Favor of Sustainability
A vast literature has confirmed that, in several economies, sustainability is a prevailing key problem, particularly in the agri-food industry. Consumers frequently like to associate themselves with sustainable items reflecting higher concern for society, healthy food, or commodities exhibiting greater fairness towards food producers. Worldwide, there is an increased awareness of consumption patterns escalating the demand for the production of sustainable items. Researchers revealed that change interventions have slowly reduced the pace of growth in the food industry, partially because of consumer awareness at a gradual rate. Moreover, sustainable food products are viewed as ineffective in the short run while market share for sustainable items remains substantially low.
  • 493
  • 06 Sep 2022
Topic Review
Quercetin in Coronavirus Infections
The COVID-19 outbreak seems to be the most dangerous challenge of the third millennium due to its highly contagious nature. Amongst natural molecules for COVID-19 treatment, the flavonoid molecule quercetin (QR) is currently considered one of the most promising. QR is an active agent against SARS and MERS due to its antimicrobial, antiviral, anti-inflammatory, antioxidant, and some other beneficial effects. QR may hold therapeutic potential against SARS-CoV-2 due to its inhibitory effects on several stages of the viral life cycle.
  • 465
  • 06 Sep 2022
Topic Review
Constructing the Biobank as a Health Place
Biobanks have been established from the beginning of the millennium as relevant infrastructures to support biomedical research. These repositories have also transformed the paradigm of collecting and storing samples and associated clinical data, moving these practices from the healthcare services and research laboratories to dedicated services. Biobanks collect a wide range of samples such as blood, tissues removed in surgeries or biopsies, saliva, hair, teeth, and feces, among others, and these would be, in most of the cases, given by donors voluntarily aiming to contribute for the advancement of biomedical research. Regardless of their health status, every person could be a biobank donor with different attributes or functions. Biobanks store these large amounts of medical information and biological samples collected in healthcare services to be used in biomedical research. These two contexts—healthcare services and research laboratories—have a significant role in determining the chain of procedures through which samples are collected and organized.
  • 312
  • 06 Sep 2022
Topic Review
Infection Control against Candidaauris in Healthcare Facilities
Candida auris is an emerging multidrug-resistant yeast with high mortality rate, especially in patients with underlying co-morbidities. It has been known to contaminate the environment and colonize human skin for prolonged periods in healthcare settings leading to difficult-to-control outbreaks. However, there is limited literature on the efficacy of different disinfectants/antiseptics, which can effectively decontaminate the environment and decolonize patients to prevent the spread of C. auris.
  • 399
  • 05 Sep 2022
Topic Review
Immunosenescence in Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) is one of the most important causes of vascular dementia. Immunosenescence and inflammatory response, with the involvement of the cerebrovascular system, constitute the basis of this disease. Immunosenescence identifies a condition of deterioration of the immune organs and consequent dysregulation of the immune response caused by cellular senescence, which exposes older adults to a greater vulnerability. A low-grade chronic inflammation status also accompanies it without overt infections, an “inflammaging” condition. The correlation between immunosenescence and inflammaging is fundamental in understanding the pathogenesis of age-related CSVD (ArCSVD). The production of inflammatory mediators caused by inflammaging promotes cellular senescence and the decrease of the adaptive immune response. Vice versa, the depletion of the adaptive immune mechanisms favours the stimulation of the innate immune system and the production of inflammatory mediators leading to inflammaging. Furthermore, endothelial dysfunction, chronic inflammation promoted by senescent innate immune cells, oxidative stress and impairment of microglia functions constitute, therefore, the framework within which small vessel disease develops: it is a concatenation of molecular events that promotes the decline of the central nervous system and cognitive functions slowly and progressively.
  • 357
  • 05 Sep 2022
Topic Review
Viral Eco-Genomic Tools for Aquatic Biomonitoring
Enteric viruses (EVs) occurrence within aquatic environments varies and leads to significant risk on public health of humans, animals, and diversity of aquatic taxa. Early and efficacious recognition of cultivable and fastidious EVs in aquatic systems are important to ensure the sanitary level of aquatic water and implement required treatment strategies. In combination with bioinformatics techniques, genetic tools including cloning sequencing analysis, DNA microarray, next-generation sequencing (NGS), and metagenomic sequencing technologies are implemented to make informed decisions about the global burden of waterborne EVs-associated diseases.
  • 411
  • 05 Sep 2022
Topic Review
Nutrition and Food Literacy in the MENA Region
Improving food and nutrition literacy is fundamental to tackling the Middle East and North Africa (MENA) region’s enormous challenges, including malnutrition and food insecurity. To direct initiatives, it is crucial to assess the region’s food and nutrition literacy. People in these countries mostly had inadequate food and/or nutrition literacy levels, especially in the skills rather than the cognitive domain. Food and/or nutrition literacy showed associations with food habits, food-label use, food-consumption patterns, school performance, food security, dietary diversity, and nutrient adequacy. The MENA countries developed no policies or programs to address food and nutrition literacy. 
  • 504
  • 02 Sep 2022
Topic Review
Real-World Evidence
Real-world evidence (RWE) is increasingly involved in the early benefit assessment of medicinal drugs. It is expected that RWE will help to speed up approval processes comparable to RWE developments in vaccine research during the COVID-19 pandemic. Definitions of RWE are diverse, marking the highly fluid status in this field. So far, RWE comprises information produced from data routinely collected on patient’s health status and/or delivery of health care from various sources other than traditional clinical trials. These sources can include electronic health records, claims, patient-generated data including in home-use settings, data from mobile devices, as well as patient, product, and disease registries. RWE has already been included in various approval procedures of regulatory authorities, reflecting its actual acceptance and growing importance in evaluating and accelerating new therapies. Since RWE research is still in a transition process, and since a number of gaps in this field have been explored, more guidance and a consented definition are necessary to increase the implementation of real-world data.
  • 513
  • 02 Sep 2022
Topic Review
Effectiveness of Physical-Activity-Based Interventions Targeting Overweight and Obesity
Overweight and obesity, including their prevalence and consequences, reflect a leading public health problem. Studies have already shown that physical activity leads to a reduction in body weight in children and adults. It is already known that physical activity is an essential component of combating overweight and obesity. Being overweight causes cardiovascular diseases, diabetes, musculoskeletal disorders, and different types of cancer. According to the WHO, the prevalence of obesity has almost tripled since 1975. In 2016, 1.9 billion people aged 18 years and older were overweight, of which 650 million individuals were considered obese.
  • 358
  • 01 Sep 2022
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