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Topic Review
Adequate Chronic Pain Care in Italy
Appropriate pain care should be regarded as a right and effectively guaranteed to people with chronic pain (CP). Additionally, the World Health Organization (WHO) has recognized the importance of addressing CP as a global public health concern and has recommended that pain management be integrated into primary healthcare systems. Many individuals with CP continue to experience barriers to accessing appropriate and effective pain care, including a lack of education and training among healthcare providers, limited availability of specialized pain clinics, and misconceptions about the use of opioid medications for pain management. Furthermore, CP patients often encounter social stigmatization and discrimination, which can further complicate their access to care. There is a need for ongoing efforts to improve the recognition, assessment, and management of chronic pain, and to ensure that individuals with CP have access to appropriate and effective pain care that addresses their physical, psychological, and social needs. Law 38, enacted in Italy in 2010, establishes the citizen’s right not to suffer.
  • 561
  • 12 Jan 2023
Topic Review
Mediterranean Dietary Patterns During Pregnancy
Pregnancy outcomes for both mother and child are affected by many environmental factors. The importance of pregnancy for ‘early life programming’ in the first 1,000 days of life is well established and maternal nutrition is an important factor contributing to a favourable environment for developing offspring. Results show that being on a Mediterranean Diet during pregnancy is associated with favourable outcomes for both maternal and offspring health, particularly for gestational diabetes in mothers and congenital defects in offspring.
  • 561
  • 30 Sep 2021
Topic Review
HIV-Related Stigma
This notwithstanding, HIV continues to be a global public health issue. Many HIV patients died from acquired immune deficiency syndrome (AIDS) related illnesses globally. Without addressing HIV-related stigma, 2030 (SDG 3) will be a very distant reality, as HIV-related stigma has been identified as a major drawback in HIV counselling and testing (VCT) uptake and ART utilization and adherence.
  • 561
  • 13 Jun 2022
Topic Review
Vaccine and Monkeypox
The monkeypox virus (MPV) is a double-stranded DNA virus belonging to the Poxviridae family, Chordopoxvirinae subfamily, and Orthopoxvirus genus. It was called monkeypox because it was first discovered in monkeys, in a Danish laboratory, in 1958. Preventing the transmission and infection of MPV is associated with different challenges. The primary strategy of prevention would be vaccination. 
  • 560
  • 24 Oct 2022
Topic Review
Brain Neurodegeneration and Cognitive Deficits after Cardiac Arrest
Cardiac arrest occurs as a result of a sudden stop of the heartbeat and its mechanical activity, which causes cessation of systemic circulation and blood flow in the brain, which triggers global brain ischemia. Brain neuropathology after cardiac arrest includes primary ischemic injury and secondary reperfusion injury, which occur sequentially, acutely during cardiac arrest and resuscitation, and chronically in the post-resuscitation stag.
  • 559
  • 29 Feb 2024
Topic Review
Subarachnoid Hemorrhage
The incidence of hemorrhagic stroke in the general population accounts for approximately 20% of all the strokes, with 5% due to subarachnoid hemorrhage (SAH). The morbidity and mortality remains high for this patient population. For aneurysmal SAH, 30% of patients die and 50% of survivors have long-term cognitive deficits that preclude their return to work. The two most important determinants of outcome after SAH are initial hemorrhage severity and secondary brain injury due to early brain injury (EBI) and delayed cerebral ischemia (DCI). EBI occurs in 12% of patients, develops 1–3 days after SAH and is characterized by blood–brain barrier (BBB) disruption, neuronal cell death, neuroinflammation and cerebral edema. DCI occurs in ~30% of patients, develops 4–12 days after SAH and is characterized by large artery vasospasm, distal autoregulatory dysfunction, microvessel thrombosis and cortical spreading depression. Though many strategies to prevent EBI and DCI have been explored over the years, none have proven efficacious. New therapies are desperately needed to treat these conditions.
  • 559
  • 29 Jun 2021
Topic Review
Meibomian Gland Dysfunction
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease and loss of ocular surface homeostasis. Increasingly, several observational clinical studies suggest that dyslipidemia (elevated blood cholesterol, triglyceride, or lipoprotein levels) can initiate the development of MGD. 
  • 558
  • 23 Nov 2021
Topic Review
Physiological Effects of Covid-19 and Exercise
The world has been severely challenged by the Coronavirus Disease (COVID-19) outbreak since the early 2020s. Worldwide, there have been more than 66 million cases of infection and over 3,880,450 million deaths caused by this highly contagious disease. All sections of the population including those who are affected, who are not affected and those who have recovered from this disease are suffering physiologically. Physiological effects of COVID-19 may be managed by exercise management as a prevention strategy. Moderate exercise including walking, yoga, and tai-chi to name but a few exercise regimes are critical in preventing COVID-19 and its complications.  
  • 559
  • 29 Dec 2021
Topic Review
Artificial Intelligence and COVID-19 Pandemic
The COVID-19 pandemic has worked as a catalyst, pushing governments, private companies, and healthcare facilities to design, develop, and adopt innovative solutions to control it, as is often the case when people are driven by necessity. After 18 months since the first case, it is time to think about the pros and cons of such technologies, including artificial intelligence—which is probably the most complex and misunderstood by non-specialists—in order to get the most out of them, and to suggest future improvements and proper adoption. 
  • 558
  • 05 Aug 2021
Topic Review
Fibrinogen in Hypofibrinogenemia
Congenital fibrinogen disorders are diseases associated with a bleeding tendency; however, there are also reports of thrombotic events. Fibrinogen plays a role in the pathogenesis of thrombosis due to altered plasma concentrations or modifications to fibrinogen’s structural properties, which affect clot permeability, resistance to lysis, and its stiffness. Several distinct types of genetic change and pathogenetic mechanism have been described in patients with bleeding and a thrombotic phenotype, including mutations affecting synthesis or processing in three fibrinogen genes.
  • 558
  • 02 Mar 2022
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