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Topic Review
Biography
Topic Review
Opioid Addiction Science and Society
Opioid abuse and misuse have led to an epidemic which is currently spreading worldwide. Since the number of opioid overdoses is still increasing, it is becoming obvious that current rather un-systematic approaches to tackle this health problem are not effective. This review suggests that fighting the opioid epidemic requires a structured public health approach. Therefore, it is important to consider not only scientific and biomedical perspectives, but societal implications and the lived experience of groups at risk as well.
661
20 Jan 2021
Topic Review
Mechanism of Bone Loss Induced by Iron Deficiency
Iron is a vital component of various enzymes involved in many biological processes, including oxygen transport, DNA biosynthesis, and cellular energy generation. Moreover, the biological activity of iron depends mainly on its efficient electron transfer properties. It has the ability to accept or donate electrons during the conversion between ferric iron (Fe3+) and ferrous iron (Fe2+), thereby functioning as a catalytic cofactor in various biochemical reactions. Therefore, iron is necessary for the growth, proliferation, and differentiation of bone cells, especially for osteoblasts and osteoclasts. In addition, hypoxia caused by iron deficiency can also lead to the activity and function disorder of bone cells. With respect to bone metabolism, iron is involved in the synthetic process of collagen and vitamin D metabolism.
661
12 Apr 2023
Topic Review
Microdosing in Business
Abusing psychoactive substances has been a popular sport in the business world since the mid-19th century. First, they were appreciated for their stimulating or tonic effects, but later with psychedelics on the scene, their importance in subculture matured. In the last decade, it has become very popular to use LSD and cocaine in subtle doses, which provides users with a high that is enough to feel their psychoactive potential, but not as high that significant behavioral changes can be seen. Unlike regular use, microdosing is usually sufficient to affect a few without undue finish and withdrawal symptoms. It allows for abuse in the regular mode of the working week with a rest phase on the weekend. The diametric difference between the abuse of standard dosing and micro-dosing is also in the decreasing tolerance of the organism.
660
29 Mar 2022
Topic Review
Glycolysis and ER Stress
Glycolysis and ER stress have been considered important drivers of pulmonary fibrosis. However, it is not clear whether glycolysis and ER stress are interconnected and if those interconnections regulate the development of pulmonary fibrosis.
660
17 Mar 2022
Topic Review
Diet/Nutrition for Cancer Survivors with Chronic Pain
Chronic pain in cancer survivors is related to obesity, malnutrition, nutritional deficiency, diet quality, immune system, systemic inflammation, and gut microbiota. As seen clearly, dietary interventions may provide weight reduction, a healthy body weight, good diet quality, regulations in systemic inflammation and immune system, and a healthy gut microbiota environment that could modify aforementioned pain-related pathways/mechanisms. For that reason, nutrition might have the potential to transition from being only prevention for cancer recurrence or cancer itself to a modality for chronic pain management for cancer survivors.
659
17 Feb 2022
Topic Review
Calculus as a Risk Factor for Periodontal Disease
Based on the 2018 classification of periodontal disease, a series of articles have been published describing the decision points of periodontal therapy and how the findings collected at those decision points can be used as guidelines for periodontal therapy.
658
11 Nov 2022
Topic Review
Work-Related Stress during Home-Based Remote Work
Remote work takes place outside a designated work location, such as corporate offices, and is often associated with working from home or working (home-based remote work) at a client’s location. In contrast, telework can be conducted remotely as well, but also focuses on the use of personal electronical devices . Ideally, job demands and job resources behave in a dynamic, balanced manner that lead to or maintain employee health. However, when work demands exceed work resources and work resources are inadequate for work demands, an imbalance occurs that leads to WRS over time.
658
31 May 2022
Topic Review
Food Security in Ghanaian Urban Cities
Urbanisation in Ghana could be negatively impacting the state of food security, especially in economically vulnerable groups. Food supply, safety, and quality are all aspects of food security which could be impacted.
658
26 Oct 2021
Topic Review
Fragmentation of Human Embryos
Embryo fragmentation represents a phenomenon generally characterized by the presence of membrane-bound extracellular cytoplasm into the perivitelline space.
656
18 Feb 2022
Topic Review
Child and Adolescent Obesity
Child and adolescent obesity constitute one of the greatest contemporary public health menaces. The enduring disproportion between calorie intake and energy consumption, determined by a complex interaction of genetic, epigenetic, and environmental factors, finally leads to the development of overweight and obesity. Child and adolescent overweight/obesity promotes smoldering systemic inflammation (“para-inflammation”) and increases the likelihood of later metabolic and cardiovascular complications, including metabolic syndrome and its components, which progressively deteriorate during adulthood. Exosomes are endosome-derived extracellular vesicles that are secreted by a variety of cells, are naturally taken-up by target cells, and may be involved in many physiological and pathological processes. Over the last decade, intensive research has been conducted regarding the special role of exosomes and the non-coding (nc) RNAs they contain (primarily micro (mi) RNAs, long (l) non-coding RNAs, messenger (m) RNAs and other molecules) in inter-cellular communications. Through their action as communication mediators, exosomes may contribute to the pathogenesis of obesity and associated disorders. There is increasing evidence that exosomal miRNAs and lncRNAs are involved in pivotal processes of adipocyte biology and that, possibly, play important roles in gene regulation linked to human obesity.
654
14 Apr 2021
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