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Topic Review
ERK5 Expression and Function in Cancer
Extracellular signal-regulated kinase 5 (ERK5) is a unique kinase among MAPKs family members, given its large structure characterized by the presence of a unique C-terminal domain. Despite increasing data demonstrating the relevance of the ERK5 pathway in the growth, survival, and differentiation of normal cells, ERK5 has recently attracted the attention of several research groups given its relevance in inflammatory disorders and cancer.
  • 431
  • 20 Jan 2022
Topic Review
Lower Cardiovascular Disease Risk in Midlife Black Women
Midlife Black women suffer disproportionately from cardiovascular disease (CVD) and stroke in comparison to White women of similar age and demographic. Risks factors  for CVD and stroke are largely considered to be modifiable yet, CVD prevention and awareness campaigns have been less effective among Black women. Decreased awareness of personal CVD risk is associated with delays in the presentation of women to the emergency room or health care providers for symptoms of myocardial infarction. The Midlife Black Women’s Stress and Wellness (B-SWELL) program was co-designed with the community to increase awareness about CVD risk factors, stress, and healthy lifestyle behaviors among midlife Black women.
  • 431
  • 14 Feb 2022
Topic Review
Robotic Surgery
The advent of robotic surgical systems had a significant impact on every surgical area, especially urology, gynecology, and general and cardiac surgery. 
  • 431
  • 30 Aug 2023
Topic Review
Sleep Disorders of Child and Mental Health
Some common sleep disorders have been identified and included as childhood sleep disorders, such as obstructive sleep apnea, parasomnias, behavioral insomnia, delayed sleep phase disorder, and restless legs syndrome. For adolescent mental health problems, the standard definition and diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders – 5th Edition (DSM-5) by the American Psychiatric Association (APA) were followed. Common adolescent mental health problems include, but are not limited to: anxiety disorder, mood disorders, attention deficit and hyperactivity disorders, and disruptive behavior disorders.
  • 431
  • 30 Nov 2021
Topic Review
Mental Stress in Medical Students during the Pandemic
Because of the COVID-19 pandemic, students had to interrupt their regular studies, and universities changed their teaching formats. The lockdowns affected students in more ways than simply their teaching formats. Students require individual support to adjust to difficult situations, and particularly medical students in their preclinical phase compared to students in their clinical phases. These are challenges for the medical education system, which must find ways to be prepared for future times of crisis and insecurity.
  • 430
  • 23 Sep 2022
Topic Review
Neuropsychiatric Complications of SARS-CoV-2 Infection
Beginning with the various strategies of the SARS-CoV-2 virus to invade the bodies and manifest infection, and ending with the long COVID, people are witnessing the evolving course of the disease in addition to the pandemic. Given the partially controlled course of the COVID-19 pandemic, the greatest challenge lies in managing the short- and long-term complications of COVID-19.
  • 430
  • 20 Dec 2022
Topic Review
Pioglitazone Use and Sepsis Mortality
The pioglitazone use via the PPARγ agonist in sepsis patients is inconclusive. It was based on a great number of animal studies. However, except for information from animal studies, there are merely no data of human for reference. This study was conducted by a unique database including 1.6 million of diabetic patients. From 1999 to 2013, a total of 145,327 type 2 diabetic patients, first admitted for sepsis, were enrolled. Propensity score matching was conducted in a 1:5 ratio between pioglitazone users and nonusers. Multivariate logistic regression was conducted to evaluate the adjusted odds ratios (aORs) of hospital mortality in pioglitazone users. Further stratification analysis and Kaplan-Meier plot were utilized. A total of 9,310 sepsis pioglitazone users (defined as "ever" use pioglitazone in any dose within 3 months prior to the first admission for sepsis) and 46,550 matched nonusers were retrieved, respectively. In the multivariate logistic regression model, the cohort of pioglitazone users (9,310) had a decreased aOR = 0.95 (95% CI, 0.89-1.02) of sepsis mortality. Further stratification analysis demonstrated that "chronic pioglitazone users" (defined as "at least" 4 weeks drug use within 3 months) (3,399) was much associated with significant aOR = 0.80 (95% CI, 0.72-0.89) in reducing sepsis mortality. This first human cohort study demonstrated the potential protective effect of chronic pioglitazone use in type 2 diabetic sepsis patients.
  • 429
  • 16 Mar 2021
Topic Review
Viral Eco-Genomic Tools for Aquatic Biomonitoring
Enteric viruses (EVs) occurrence within aquatic environments varies and leads to significant risk on public health of humans, animals, and diversity of aquatic taxa. Early and efficacious recognition of cultivable and fastidious EVs in aquatic systems are important to ensure the sanitary level of aquatic water and implement required treatment strategies. In combination with bioinformatics techniques, genetic tools including cloning sequencing analysis, DNA microarray, next-generation sequencing (NGS), and metagenomic sequencing technologies are implemented to make informed decisions about the global burden of waterborne EVs-associated diseases.
  • 429
  • 05 Sep 2022
Topic Review
Effects of Transcranial Electrical Stimulation in Numerical Cognition
It's showed that tRNS, thus far, seems to be the most promising transcranial electrical stimulation (tES) technique to enhance numerical cognition. Although the application of tES as a neuroenhancement or treatment approach in numerical cognition is promising, some questions remain. The optimal parameters and procedures of tES, the transfer effect to untrained numerical aspects, the sustained improvements in different aspects of numerical cognition, and the benefits of applying advanced tES techniques (i.e., HD-tDCS, tACS) have yet to be determined.
  • 429
  • 29 Apr 2022
Topic Review
The Relationship between Personality Traits and COVID-19 Anxiety
The COVID-19 pandemic has created a lot of fear and anxiety globally. The current study attempted to investigate the association among the big five personality traits and the two factors of COVID-19 pandemic anxiety (fear and somatic concern). Further, sleep quality as a mediator between personality traits and pandemic anxiety was also assessed. The study involved a cross-sectional sample of 296 adult Indians who were administered the 10-item short version of BFI along with the COVID-19 Pandemic Anxiety Scale and Sleep Quality Scale. Path analysis was used to test the theoretical model that we proposed. The overall model has explained 6% and 36% of the variance, respectively, for the factors of fear and somatic concern of COVID-19 pandemic anxiety. The path analysis model indicated that only the trait of neuroticism showed a significant direct and indirect effect on pandemic anxiety in the sample. Those scoring high on neuroticism indicated high levels of fear as well as somatic concern. Neuroticism also showed partial mediation through sleep quality on the factor of somatic concern. Agreeableness was the only other personality trait that indicated a significantly negative relationship with the factor of somatic concern. These relationships were independent of age, gender, and occupational status. These findings provide a preliminary insight into the slightly different relationship which has emerged between personality and COVID-19 pandemic anxiety in comparison to general anxiety. 
  • 429
  • 27 Jan 2022
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