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Topic Review
Lifestyle and Hepatocellular Carcinoma
Liver cancer remains a global health challenge, and while infection by hepatitis B virus and hepatitis C virus are the main risk factors for hepatocellular carcinoma (HCC) development, non-alcoholic steatohepatitis is associated with metabolic syndrome or diabetes mellitus is becoming a more frequent risk factor.
  • 453
  • 07 Jan 2022
Topic Review
Oral Microbiome Dysbiosis in Tongue Squamous Cell Carcinoma
Tongue squamous cell carcinoma(TSCC),as the most common  oral squamous cell carcinoma (OSCC), is associated with numerous risk factors. Among which oral microbiota is recognized by more and more scholars. In the oral cavity, bacteria can aggregate into colonies to form functional biofilms, and the synergistic interaction of polymicroorganisms can maintain homeostasis with the host. However, Changes in specific individual bacterial components may cause colony effects that disrupt homeostasis, which would contribute to the initiation and progression of TSCC. For instance,the change of  relative abundance of Firmicutes, Actinobacteria, Proteobacteria, Bacteroidetes, Fusobacteria and related bacteria can cause the occurrence of tongue cancer by mediating chronic inflammatory states, suppressing immune responses, synthesizing carcinogens, attenuating synthesis of anticancer agents and promoting cancer cell invasion. Therefore, the management of the  special microbiome associated with tumour microenvironments may be a promising treatment strategies for tumors in the future.
  • 453
  • 11 Oct 2022
Topic Review
Materials for 3D Bioprinting
Three-dimensional (3D) bioprinting has emerged as a promising scaffold fabrication strategy for tissue engineering with excellent control over scaffold geometry and microstructure. Nanobiomaterials as bioinks play a key role in manipulating the cellular microenvironment to alter its growth and development.
  • 453
  • 12 Apr 2023
Topic Review
Disabled People during Pandemics
From a population health perspective, during disease outbreaks and pandemics, including the COVID-19 pandemic, along with the general population, it is important for governments to include people with disability in their pandemic planning and response.
  • 452
  • 29 Jun 2021
Topic Review
Asthma and Chronic Obstructive Pulmonary Diseases
Asthma and chronic obstructive pulmonary disease (COPD) are prevalent chronic pulmonary diseases requiring ongoing self-management. According to the World Health Organization, approximately 339 million people worldwide have asthma, and over 65 million suffer from moderate-to-severe COPD, making it the third leading cause of death worldwide. Asthma typically starts early in life and is related to an allergy, whereas COPD is typically caused by air pollutants such as cigarette smoke or biomass fuel.
  • 452
  • 19 Nov 2021
Topic Review
Relationship between Severe Asthma and Nasal Polyps
Chronic rhinosinusitis is a common disease worldwide and can be categorized into chronic rhinosinusitis with nasal polyps and chronic rhinosinusitis without nasal polyps. Chronic rhinosinusitis with nasal polyps is common in patients with asthma and, particularly, severe asthma. Severe asthma is effectively treated with biologics and the coexistence of severe asthma with chronic rhinosinusitis with nasal polyps presents a phenotype that is more likely to respond to such treatment.
  • 452
  • 02 Jul 2022
Topic Review
Minimally Invasive Capsule Panendoscopy
In the early 2000s, the introduction of single-camera wireless capsule endoscopy (CE) redefined small bowel study. Progress continued with the development of double-camera devices, first for the colon and rectum, and then, for panenteric assessment. Advancements continued with magnetic capsule endoscopy (MCE), particularly when assisted by a robotic arm, designed to enhance gastric evaluation.
  • 455
  • 04 Mar 2024
Topic Review
Active Aging and Smart Public Parks
The global population is aging, with the percentage of people over 60 expected to rise from 12% to 22% and 33% residing in developed countries. However, most cities lack the appropriate infrastructure to support aging citizens in active aging and traversing the urban landscape, negatively impacting their quality of life. Studies have shown that public parks and green spaces can contribute to a higher quality of life and wellbeing. Also, smart cities are intended to improve the wellbeing and health of their inhabitants. However, most solutions are typically implemented indoors and tend to overlook the needs of older adults. A smart city should consider the increasing rate of aging and give more importance to outdoor environments as a key aspect of quality of life. 
  • 451
  • 04 Dec 2023
Topic Review
The Role of NLRP3 Inflammasome in IgA Nephropathy
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide today. The NLRP3 inflammasome is a polyprotein complex and an important participant in inflammation. The NLRP3 inflammasome participates in a variety of kidney diseases, including IgAN. 
  • 452
  • 31 Jan 2023
Topic Review
Cellular Neurobiology of Psychedelics
Psychedelic substances have gained significant attention in recent years for their potential therapeutic effects on various psychiatric disorders.
  • 451
  • 07 Nov 2023
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