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Topic Review
Feeding Abilities in Achondroplasia Patients
Achondroplasia is an autosomal dominant genetic disease representing the most common form of human skeletal dysplasia: almost all individuals with achondroplasia have identifiable mutations in the fibroblast growth factor receptor type 3 (FGFR3) gene. The cardinal features of this condition and its inheritance have been well-established, but the occurrence of feeding and nutritional complications has received little prominence. In infancy, the presence of floppiness and neurological injury due to foramen magnum stenosis may impair the feeding function of a newborn with achondroplasia. Along with growth, the optimal development of feeding skills may be affected by variable interactions between midface hypoplasia, sleep apnea disturbance, and structural anomalies. Anterior open bite, prognathic mandible, retrognathic maxilla, and relative macroglossia may adversely impact masticatory and respiratory functions. Independence during mealtimes in achondroplasia is usually achieved later than peers. Early supervision of nutritional intake should proceed into adolescence and adulthood because of the increased risk of obesity and respiratory problems and their resulting sequelae. 
  • 504
  • 29 Jan 2023
Topic Review
Factors Influencing Community Health Workers’ Preparedness for ICT
Globally, community health workers (CHWs) are increasingly viewed as an integral part of the health system as opposed to simply being an extension of it. Given this view, most low- or middle-income countries (LMICs) have refocused their efforts on reorganising CHW initiatives to maximise their impact. In 2011, the South African Department of Health formally integrated community health workers (CHWs) into the national health system to strengthen primary healthcare delivery following the Universal Health Coverage (UHC) principles and the South African National Development Plan 2030. Several studies have found that most CHWs are comfortable providing clinical treatment but are unsure how to translate epidemiological and socio-demographic data into relevant information for service delivery. Information and communication technology (ICT) provides a viable mechanism for assisting CHWs with information appropriation.
  • 437
  • 29 Jan 2023
Topic Review
Spermatozoon Effect on Embryo Development
The intracytoplasmic sperm injection (ICSI) technique was invented to solve severe male infertility due to altered sperm parameters. It is applied worldwide for the treatment of couple infertility. ICSI is performed with any available spermatozoon from surgery or ejaculated samples, whatever are the sperm motility, morphology or quantity. The causes of male infertility are crucial in building a competent spermatozoa that will contribute to normal embryonic development and healthy offspring.
  • 306
  • 28 Jan 2023
Topic Review
SARS-CoV-2 Spike Protein-Induced Dysfunction of the NRP-1/VEGF-A Complex
Long coronavirus disease-19 (COVID-19) is a newly discovered syndrome characterized by multiple organ manifestations that persist for weeks to months, following the recovery from acute disease. Occasionally, neurological and cardiovascular side effects mimicking long COVID-19 have been reported in recipients of COVID-19 vaccines. Hypothetically, the clinical similarity could be due to a shared pathogenic role of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike (S) protein produced by the virus or used for immunization. The S protein can bind to neuropilin (NRP)-1, which normally functions as a coreceptor for the vascular endothelial growth factor (VEGF)-A. By antagonizing the docking of VEGF-A to NRP-1, the S protein could disrupt physiological pathways involved in angiogenesis and nociception. One consequence could be the increase in unbound forms of VEGF-A that could bind to other receptors. SARS-CoV-2-infected individuals may exhibit increased plasma levels of VEGF-A during both acute illness and convalescence, which could be responsible for diffuse microvascular and neurological damage.
  • 446
  • 20 Jan 2023
Topic Review
Citrus Flavone Nobiletin and Circadian Rhythms
The importance of the circadian clock in maintaining human health is now widely acknowledged. Dysregulated and dampened clocks may be a common cause of age-related diseases and metabolic syndrome Thus, circadian clocks should be considered as therapeutic targets to mitigate disease symptoms. 
  • 621
  • 19 Jan 2023
Topic Review
PENG-Based Non-Invasive Medical Sensors
Piezoelectric nanogenerators (PENGs) not only are able to harvest mechanical energy from the ambient environment or body and convert mechanical signals into electricity but can also inform people about pathophysiological changes and communicate this information using electrical signals, thus acting as medical sensors to provide personalized medical solutions to patients.
  • 484
  • 19 Jan 2023
Topic Review
Isoniazid Preventive Therapy for Tuberculosis among HIV Patients
Tuberculosis (TB) is a major cause of morbidity and mortality in people living with HIV (PLWHIV). Isoniazid preventive therapy (IPT) prevents TB in PLWHIV, but estimates of its effects and actual implementation vary across countries. PLHIV who were on IPT, independently or simultaneously with ART, were less likely to develop TB than those without IPT. IPT interventions had a significant association with improved CD4 count and reduced all-cause mortality. IPT was less effective in people with advanced HIV infection. The major factors influencing IPT implementation and uptake were stock-outs, fear of developing isoniazid-resistant TB, patient’s refusal and non-adherence, and improper counseling and low commitment of HIV clinical care providers. IPT alone or in combination with ART significantly reduces the incidence of TB and mortality in PLHIV in Ethiopia than those without IPT. More research on safety is needed, especially on women with HIV who receive a combination of IPT and ART. 
  • 314
  • 19 Jan 2023
Topic Review
Genetic Polymorphisms as Biomarkers of Susceptibility
A clean environment is fundamental to human health and well-being. However, environment can be a souce of  various stressors, such as bad quality of air, pollution, noise and hazardous substances affecting our health.The human health is also influenced by climate change, producing flood, heatwaves and presence of vector-borne disease affecting the global health. The climate changes, loss of biodiversity loss and land degradation contribute to impact the human well-being. Human health is influenced by various factors; these include genetic inheritance, behavioral lifestyle, socioeconomic and environmental conditions, and public access to care and therapies in case of illness, with the support of the national health system. All these factors represent the starting point for the prevention and promotion of a healthy lifestyle. However, it is not clear to what extent these factors may actually affect the health of an entire population. The exposures to environmental and occupational factors are several, most of which might be poorly known, contributing to influencing the individual health. Personal habits, including diet, smoking, alcohol, and drug consumption, together with unhealthy behaviors, may inevitably lead people to the development of chronic diseases, contributing to increase aging and decrease daily life expectancy. Despite such risks, humans should modify the bad habits in favour of virtuous habits. 
  • 299
  • 19 Jan 2023
Topic Review
Sustainable Health Care Provision Worldwide
Quality health care is an essential human right, on the agenda of sustainable development and presents a challenge in the twenty-first century. There are different perspectives regarding the price and quality of health care, and it is necessary to review the quality health care issue and how it influenced by price. Health care is a service industry, needs basic standards and specialized human resources to perform the procedure, and quality health care is not associated with an extra price. The quality of health care assures sustainability. Likewise, there are some additional choices during certain procedures, and those may have different price options and would be linked with quality. So, those optional health care and basic health need to define separately.
  • 250
  • 19 Jan 2023
Topic Review
Methylmercury, DNA, and Chromatin
Methylmercury (MeHg) is an environmental neurotoxin that can adversely affect the development of the nervous system. The molecular integrity of chromatin in the nucleus is an important target of MeHg. Low levels of MeHg trigger epigenetic mechanisms that may be involved in long-lasting and transgenerational neurotoxicity after exposure. Emerging evidence has shown that these mechanisms include histone modification, short interfering RNA (siRNA), and DNA methylation.
  • 378
  • 19 Jan 2023
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