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Topic Review
Anticancer Strategies Targeting JWA
JWA is a microtubule-associated protein and an environmental response gene. JWA has been identified as a potential therapeutic target for several cancers. 
  • 411
  • 08 Oct 2022
Topic Review
Lower Cardiovascular Disease Risk in Midlife Black Women
Midlife Black women suffer disproportionately from cardiovascular disease (CVD) and stroke in comparison to White women of similar age and demographic. Risks factors  for CVD and stroke are largely considered to be modifiable yet, CVD prevention and awareness campaigns have been less effective among Black women. Decreased awareness of personal CVD risk is associated with delays in the presentation of women to the emergency room or health care providers for symptoms of myocardial infarction. The Midlife Black Women’s Stress and Wellness (B-SWELL) program was co-designed with the community to increase awareness about CVD risk factors, stress, and healthy lifestyle behaviors among midlife Black women.
  • 410
  • 14 Feb 2022
Topic Review
Program ROSE (Removing Obstacles to Cervical Screening)
Program ROSE (removing obstacles to cervical screening) is a primary HPV-based cervical screening program that incorporates self-sampling and digital technology, ensuring that women are linked to care. It was developed based on the principles of design thinking in the context of Malaysia. The program illustrates the importance of collaborative partnerships and addressing the multi-faceted barriers from policy changes, and infrastructure readiness to the implementation of a radically new cervical screening program in communities. The paradigm shift in cervical cancer requires a monumental and concerted effort in educating both the healthcare providers and the general public. 
  • 410
  • 19 Oct 2022
Topic Review
Non-Pharmacological Interventions for Wandering in Patients with Dementia
Aberrant motor behaviour or wandering refers to aimless movement without a specific purpose. Wandering is common in patients with dementia and leads to early institutionalization and caregivers’ burden. Non-pharmacological interventions should be also considered as a first-line solution for the wandering because current pharmacological treatment has serious side-effects. 
  • 409
  • 20 Jan 2022
Topic Review
ERK5 Expression and Function in Cancer
Extracellular signal-regulated kinase 5 (ERK5) is a unique kinase among MAPKs family members, given its large structure characterized by the presence of a unique C-terminal domain. Despite increasing data demonstrating the relevance of the ERK5 pathway in the growth, survival, and differentiation of normal cells, ERK5 has recently attracted the attention of several research groups given its relevance in inflammatory disorders and cancer.
  • 409
  • 20 Jan 2022
Topic Review
Infections of the Orofacial Region
The natural flora of the mouth is very diverse. After the large intestine, it has the second highest complexity in terms of microorganisms, including more than 700 microorganisms. Each tissue has specific microbes that are different from adjacent tissues’ microbes. Still, these microbes can be displaced under certain conditions, such as the effects of cytotoxic drugs, oral cancer, or epithelial atrophy. The oral flora is divided into two categories, static and transient, which regularly balance with the host and protect against pathogenic microorganisms. The static flora on oral cavity surfaces is known as biofilm that can improve or protect oral health against pathogens, increase the virulence of potentially harmful microorganisms, and reduce the effectiveness of antimicrobial agents. Infections caused by bacteria in the mouth include caries and periodontitis. Microorganisms can attack different parts of the mouth via different mechanisms.
  • 408
  • 07 Mar 2023
Topic Review
Environmental Stressors and the PINE Network
Both psychosocial and physical environmental stressors have been linked to chronic mental health and chronic medical conditions. The psycho-immune-neuroendocrine (PINE) network details metabolomic pathways which are responsive to varied stressors and link chronic medical conditions with mental disorders, such as major depressive disorder via a network of pathophysiological pathways. Biological links have been established between particulate matter (PM) exposure, key sub-networks of the PINE model and mental health sequelae, suggesting that in theory, long-term mental health impacts of PM exposure may exist, driven by the disruption of these biological networks. This disruption could trans-generationally influence health; however, long-term studies and information on chronic outcomes following acute exposure event are still lacking, limiting what is known beyond the acute exposure and all-cause mortality. More empirical evidence is needed, especially to link long-term mental health sequelae to PM exposure, arising from PINE pathophysiology. 
  • 408
  • 20 Dec 2022
Topic Review
Effects of Transcranial Electrical Stimulation in Numerical Cognition
It's showed that tRNS, thus far, seems to be the most promising transcranial electrical stimulation (tES) technique to enhance numerical cognition. Although the application of tES as a neuroenhancement or treatment approach in numerical cognition is promising, some questions remain. The optimal parameters and procedures of tES, the transfer effect to untrained numerical aspects, the sustained improvements in different aspects of numerical cognition, and the benefits of applying advanced tES techniques (i.e., HD-tDCS, tACS) have yet to be determined.
  • 408
  • 29 Apr 2022
Topic Review
Therapeutic Aquatic Exercise in Pregnancy
Aquatic physical exercise aimed at pregnant women has proliferated in recent years, thanks to the benefits provided by the aquatic environment, such as a decrease in gravitational pull, an improved sense of physical comfort, improved mobility and flexibility, reduction of post-exercise pain and an improvement of venous return due to the increased hydrostatic pressure.
  • 407
  • 29 Mar 2022
Topic Review
Effect of Sex Hormones on Migraine
Sex hormones and migraine are closely interlinked. Women report higher levels of migraine symptoms during periods of sex hormone fluctuation, particularly during puberty, pregnancy, and perimenopause. Ovarian steroids, such as estrogen and progesterone, exert complex effects on the peripheral and central nervous systems, including pain, a variety of special sensory and autonomic functions, and affective processing. A panel of basic scientists, when challenged to explain what was known about how sex hormones affect the nervous system, focused on two hormones: estrogen and oxytocin.
  • 407
  • 11 Mar 2024
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