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Topic Review
VISTA, PDL-L1, and BRAF—Markers in Prognosis of Melanoma
Melanoma is currently known as one of the most aggressive malignant tumors. T cell Activation (VISTA) is a novel target that is considered to be highly important in determining the invasive potential and treatment response of a melanoma. Programmed death-ligand 1 (PD-L1) is a marker with whose importance has been revealed in multiple types of malignancies.
  • 438
  • 29 Mar 2022
Topic Review
Probiotics and Prebiotics Concepts
Probiotics are microorganisms which, if taken in sufficient quantities, contribute positively to the health of the host and are the focus of both scientific studies and commercial companies. 
  • 438
  • 06 Apr 2023
Topic Review
Sex Disparity in Cardiovascular Disease
Among cardiovascular diseases, acute myocardial infarction (AMI) shows significant differences in occurrence rate, prognosis and efficacy of treatment between male and female patients. Genomics and epigenomics approaches together with epidrugs design and drug repositioning could fill the sex-gap.
  • 437
  • 29 Mar 2022
Topic Review
Placental Evaluation In Vivo Models to Evaluate Nanocarriers
Pregnancy-associated disorders affect around 20% of pregnancies each year around the world. The risk associated with pregnancy therapeutic management categorizes pregnant women as “drug orphan” patients. In the last few decades, nanocarriers have demonstrated relevant properties for controlled drug delivery, which have been studied for pregnancy-associated disorders. To develop new drug dosage forms it is mandatory to have access to the right evaluation models to ensure their usage safety and efficacy. 
  • 437
  • 27 Apr 2022
Topic Review
Positive Affect Evoked by Music and the Arts
A positive experience in response to a piece of music or a work of art (hence ‘music/art’) has been linked to health and wellbeing outcomes but can often be reported as indescribable (ineffable), creating challenges for research. There are two simultaneously occurring classes of experience are proposed: the ‘emotion class’ of experience (ECE) and the positive ‘affect class’ of experience (PACE). ECE consists of conventional, discrete, and communicable emotions with a reasonably well-established lexicon. PACE relates to a more private world of prototypical aesthetic emotions and experiences investigated in positive psychology.
  • 437
  • 25 May 2022
Topic Review
Risk Perception of Air Pollution
The adverse health effects of exposure to air pollutants, notably to particulate matter (PM), are well-known, as well as the association with measured or estimated concentration levels. The role of perception can be relevant in exploring effects and pollution control actions.
  • 436
  • 27 Sep 2022
Topic Review
MPM Nodal Status: Where are We at?
Due to the lack of both prospective trial and high-volume retrospective studies, the management of clinical N+ malignant pleural mesothelioma (MPM) patients remain highly debated. Node positive patients show poor survival compared with node-negative ones; thus, lymph node staging appears crucial in determining treatment strategy. Notwithstanding the improvement in pre-treatment staging and the update on lymph node classification in the 8th edition of TNM, several open controversies remain on N parameter. How should people stage suspected N+ patients? How should people treat node positive patients?  Which is the definition of “resectable patient”?  Is the site or the number the main prognostic factor for node positive patients?  The aim of the entry is to analyse the existing relevant literature on lymph node status in MPM.
  • 436
  • 09 Nov 2021
Topic Review
Lower Strength Alcohol Products
European consumers are increasingly buying and drinking lower strength alcohol products over time, with some two fifths doing so to drink less alcohol. It tends to be younger more socially advantaged men, and existing heavier buyers and drinkers of alcohol, who take up lower strength alcohol products. Substitution leads to a lower number of grams of alcohol bought and drunk.  Buying and drinking lower strength products do not appear to act as gateways to buying and drinking higher strength products. Producer companies are increasing the availability of lower strength alcohol products, particularly for beer, with extra costs of production offset by income from sales. Lower strength alcohol products tend to be marketed as compliments to, rather than substitutes of, existing alcohol consumption. Production of lower strength alcohol products could impair the impact of existing alcohol policy through alibi marketing (using the brand of lower strength products to promote higher strength products), broadened normalization of drinking cultures, and pressure to weaken policies. In addition to increasing the availability of lower strength products and improved labelling, the key policy that favours substitution of higher strength alcohol products with lower strength products is an alcohol tax based on the dose of alcohol across all products. 
  • 435
  • 20 Oct 2022
Topic Review
Association between Dietary Inflammatory Index and Colorectal Cancer
The advent of the Dietary Inflammatory Index (DII) provides a quantitative means to study the relationship between the pro-inflammatory diet and CRC. It allows the assessment of the inflammatory potential of individual food items using an FFQ, by which a DII score can be calculated. A higher DII score suggests a stronger inflammatory potential of a food item. The Dietary Inflammatory Index (DII) was extensively used to examine the inflammatory potential of diet related to colorectal cancer (CRC).
  • 435
  • 13 Apr 2022
Topic Review
Attitudes toward Female Genital Mutilation/Circumcision
Understanding the attitudes toward FGM/C held by people who have been involved in this practice can lead to more active interventions to prevent this harmful practice.  Circumcised women can play a key role in encouraging the abandonment of FGM/C through educational and cultural campaigns. 
  • 435
  • 23 Sep 2021
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