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Topic Review
Regulation and Secretion of Glucagon in Nutrient Composition
Glucagon was initially regarded as a hyperglycemic substance; however, research has revealed its broader role in metabolism, encompassing effects on glucose, amino acids (AAs), and lipid metabolism. Notably, the interplay of glucagon with nutrient intake, particularly of AAs, and non-nutrient components is central to its secretion. Fasting and postprandial hyperglucagonemia have long been linked to the development and progression of type 2 diabetes (T2DM). However, studies have brought to light the positive impact of glucagon agonists on lipid metabolism and energy homeostasis. 
  • 153
  • 20 Nov 2023
Topic Review
Reducing the Children’s Intake of Ultra-Processed Foods
Excessive fat and fatty acids intake are associated with significant health hazards such as obesity or chronic diseases. The implementation of a relevant strategy for fat reduction, especially from ultra-processed foods, considered as low nutrient energy-dense products, is needed to promote health among children and prevent diet-related chronic diseases.
  • 470
  • 29 Jan 2022
Topic Review
Reducing Postpartum Weight Retention
Postpartum weight retention (PPWR) is a strong predictor of obesity in later life with long term health consequences in women. Suboptimal lifestyle behaviours (e.g. diet and physical activity) contribute to PPWR. Postpartum lifestyle interventions are known to be efficacious in reducing PPWR, however there are challenges to their successful implementation. 
  • 462
  • 22 Jun 2021
Topic Review
Red Seaweed Pigments
Algae taxa are notably diverse regarding pigment diversity and composition, red seaweeds (Rhodophyta) being a valuable source of phycobiliproteins (phycoerythrins, phycocyanin, and allophycocyanin), carotenes (carotenoids and xanthophylls), and chlorophyll a. These pigments have a considerable biotechnological potential, which has been translated into several registered patents and commercial applications. 
  • 1.7K
  • 20 Jan 2022
Topic Review
Recurrent and Residual Caries with Resin Composite Restorations
Caries is the most widely prevailing noncommunicable disease, and is a multifactorial process presently considered as biofilm-mediated rather than an infectious disease. According to the ecological plaque hypothesis, caries occurs as a result of an imbalance of oral microflora—normally more than 700 species—leading to an increase in cariogenic bacteria such as Streptococcus mutans and Lactobacilli types. The accumulating cariogenic bacteria produce acids such as lactic acid that reduce the local pH, leading first to demineralization and later to the destruction of the organic matrix. Caries progresses when demineralization cycles prevail and remineralization cycles cease. Classically, bacterial proteases are blamed for the proteolytic process taking place because of dental caries. Recently, it has become increasingly evident that activated endogenous matrix metalloproteinases (MMPs) and cystine cathepsins of salivary, gingival crevicular fluid and dentinal origin, together with bacterial proteases, share in degrading the dentin matrix of demineralized dentin. This takes place at neutralized pH levels where the buffering effect of saliva takes place, since MMPs operate only in neutral pH values.
  • 1.3K
  • 24 Nov 2022
Topic Review
Recreational Nitrous Oxide Use
Nitrous oxide (N2O) is a dissociative anaesthetic that is sometimes used recreationally. The prevalence of N2O use is difficult to quantify but appears to be increasing. Research on N2O harms and application of harm reduction strategies are limited. The disparate body of research on recreational nitrous oxide use to inform harm reduction approaches tailored for young people was collated and synthesised. 
  • 372
  • 28 Sep 2022
Topic Review
Recessive Achromatopsia in Original Braunvieh Cattle
Sporadic occurrence of inherited eye disorders has been reported in cattle but so far pathogenic variants were found only for rare forms of cataract but not for retinopathies.
  • 413
  • 03 Dec 2021
Topic Review
Receptor-Mediated Targeted Delivery of Surface-ModifiedNanomedicine in Breast Cancer
Breast cancer therapeutic intervention continues to be ambiguous owing to the lack of strategies for targeted transport and receptor-mediated uptake of drugs by cancer cells. In addition to this, sporadic tumor microenvironment, prominent restrictions with conventional chemotherapy, and multidrug-resistant mechanisms of breast cancer cells possess a big challenge to even otherwise optimal and efficacious breast cancer treatment strategies. Surface-modified nanomedicines can expedite the cellular uptake and delivery of drug-loaded nanoparticulate constructs through binding with specific receptors overexpressed aberrantly on the tumor cell.
  • 551
  • 07 Feb 2022
Topic Review
Reasons for Withdrawal of Microplastics from Abrasive Cosmetics
Microplastics have been widely used in cosmetics and, among other things, very often as an abrasive component in peelings. This type of additive is not the main cause of environmental microplastic contamination, but it can pose a significant threat to the environment and to people. Manufacturers are increasingly taking the decision to withdraw microplastics from cosmetics, replacing them with alternatives, and this is also happening because of legal requirements. 
  • 317
  • 17 Nov 2023
Topic Review
Reasons for Delayed Diagnosis of Pediatric Acute Appendicitis
Reasons delaying the diagnosis of pediatric appendicitis were discerned. Each cause will be discussed separately although it must be noted that there is a significant overlap between them. Time to hospital admission, duration of symptoms and hospitalization time until surgery will be discussed further as indicative measures of delayed diagnosis. Patient outcomes as conveyed by selected studies will be cited in relation to time to hospital admission so that the reader can appraise their potential importance.
  • 251
  • 16 Aug 2023
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