Topic Review
Mechanism of CRISPR/Cas Based Detection
In the pace of time, numerous platforms for rapid nucleic acid (NA) detection have been developed; however, they may not be able to satisfy the ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free and Deliverable to end-users) parameters set by the World Health of Organization at the same time. Recent studies have established that the CRISPR/Cas system possesses the potential to fulfil ASSURED criteria and demonstrated that it may be repurposed for the detection of contaminants, enzymes, proteins, analytes, and plant diseases, rather than being limited to clinical settings and nucleic acids. Several platforms have yet to be translated into clinical applications and must be brought into clinical settings from the laboratory. 
  • 2.3K
  • 08 Jun 2022
Topic Review
Thyroid Function and Suicidal Behavior
Thyroid disease is a very common condition that influences the entire human body, including cognitive function and mental health. As a result, thyroid disease has been associated with multiple neuropsychiatric conditions. However, the relationship between thyroid dysfunction and suicide is still controversial. 
  • 2.3K
  • 28 Jul 2021
Topic Review
Drone Brood
Drone brood homogenate (known as apilarnil or less apistimul) is a bee product obtained by the collection of drone (male honeybees)  larvae from drone cells of honey comb, from 3 to 11 days after hatching. Apilarnil, which may be defined as the male equivalent of royal jelly, is obtained from drone brood and then freeze-dried. Etymologically, the term originates from “api” for bee, “lar” for larvae, and “nil” as a shortened form of its discoverer’s name - Romanian apitherapist Nicholae Iliesiu. 
  • 2.3K
  • 17 Dec 2020
Topic Review
Production and Use of Typical Rubber Antioxidants
Antioxidants are prevalently used during rubber production to improve rubber performance, delay aging, and extend service life. Studies have revealed that their transformation products (TPs) could adversely affect environmental organisms and even lead to environmental events, which led to great public concern about environmental occurrence and potential impacts of rubber antioxidants and their TPs.
  • 2.3K
  • 22 Dec 2022
Topic Review
History of Human Movement Studies
Knowing the genesis of ideas is important to understand why we are studying a topic. This topic review is an historical excursus about the origin of movement studies, following the ideas of Aristotle until positivism. The main ideas at the origin of biomechanical studies are historically reviewed, with special focus on the enlightment era. Key figures at the origin of movement studies were presented, together with the main ideas they introduced, most of which are still at the basis of modern research in the field of biomechanics. The entry can be of interest for all professionals working in the field of human and animal movement studies.
  • 2.3K
  • 29 Mar 2022
Topic Review
Compensatory Carry-Over Action Model (CCAM)
The Compensatory Carry-Over Action Model (CCAM) is innovative as most behavioral theories only model single activity. The CCAM, however, models different single activities—such as physical activity and nutrition —and how they change as a result of one another. Such lifestyle activities are assumed to be formed by higher-level goals, which can drive activity volitionally or unconsciously, and are rather unspecific. They become specific because of activities that are subjectively seen as leading to this goal. Each activity must be intended, pursued, and controlled. Specific resources ensure that individuals have the chance to translate their intentions into activity and that they resist distractors. Compensation and transfer (also called carry-over) operate between the different activities. If people devote all of their energy to one domain and believe that no resources remain for the other activity, compensation can help to attain goals. It is also possible that an individual successfully performs one activity, and existing or developing resources may be transferred to another activity.
  • 2.2K
  • 16 Dec 2020
Topic Review
Stretching and Inflammation
Stretching is one of the popular elements in physiotherapy and rehabilitation. When correctly guided, it can help minimize or slow down the disabling effects of chronic health conditions. Most likely, the benefits are associated with reducing inflammation.
  • 2.2K
  • 13 Sep 2022
Topic Review
Pathophysiology and Classification of Disc Herniation
Low-back pain (LBP) is a broad category of musculoskeletal disorders regarded as one of the primary causes of disability in the general population, with a lifetime incidence of 65–85% of individuals worldwide. One of the specific causes of LBP is lumbar intervertebral disc disorders with nerve root irritation. Most individuals affected fall within the age range of 30 to 50 years, with a higher prevalence in men than in women. The intervertebral disc is formed by an inner nucleus pulposus (NP), an outer annulus fibrosus (AF), and the cartilaginous endplates that attach the disc to its vertebrae. The protrusion of disc material into the spinal canal from outside the annular lining is known as herniation. When compared to other regions, the lumbar region is where disc herniation is most commonly observed, especially at the L4-L5 and L5-S1 levels. Lumbar disc herniation associated with radiculopathy (LDHR) is the outcome of the extruded disc material pressing into or contacting the lumbar nerve roots.
  • 2.2K
  • 18 Feb 2024
Topic Review
Artemisia- Antiviral and Immunomodulation Effects
Artemisia is one of the most widely distributed genera of the family Astraceae with more than 500 diverse species growing mainly in the temperate zones of Europe, Asia and North America. The plant is used in Chinese and Ayurvedic systems of medicine for its antiviral, antifungal, antimicrobial, insecticidal, hepatoprotective and neuroprotective properties. Research based studies point to Artemisia’s role in addressing an entire gamut of physiological imbalances through a unique combination of pharmacological actions. Terpenoids, flavonoids, coumarins, caffeoylquinic acids, sterols and acetylenes are some of the major phytochemicals of the genus. Notable among the phytochemicals is artemisinin and its derivatives (ARTs) that represent a new class of recommended drugs due to the emergence of quinoline drug-resistant pathogens.
  • 2.2K
  • 30 Sep 2021
Topic Review
Land Degradation and Human Health
The land provides vital resources to support life on Earth. Land ecosystems services have social, cultural, and spiritual benefits and promote human health and well-being. However, human activities, particularly ongoing unsustainable land practices, are negatively impacting ecosystems through desertification, land degradation and drought (DLDD).
  • 2.2K
  • 03 Feb 2021
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