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Topic Review
Bidirectional Relationship between Gut Dysbiosis, Anxiety and Depression
Inflammatory bowel disease represents one of the most life-altering gastrointestinal pathologies, with its multifactorial nature and unclear physiopathology. The most relevant clinical forms, ulcerative colitis and Crohn’s disease, clinically manifest with mild to severe flares and remission periods that alter the patient’s social, familial and professional integration. The chronic inflammatory activity of the intestinal wall determines severe modifications of the local environment, such as dysbiosis, enteric endocrine, nervous and immune system disruptions and intestinal wall permeability changes. These features are part of the gastrointestinal ecosystem that modulates the bottom-to-top signaling to the central nervous system, leading to a neurobiologic imbalance and clinical affective and/or behavioral symptoms. The gut-brain link is a bidirectional pathway and psychological distress can also affect the central nervous system, which will alter the top-to-bottom regulation, leading to possible functional digestive symptoms and local inflammatory responses. In the middle of this neuro-gastrointestinal system, the microbiome is a key player, as its activities offer basic functional support for both relays.
  • 261
  • 14 Sep 2023
Topic Review
Sources of Perfluoroalkyl Substances in Edible Oil
Given the heightened awareness of perfluoroalkyl substances (PFASs) globally, it is especially critical to identify the sources of PFAS pollution in edible oils. Having a thorough knowledge of the causes of PFAS pollution in edible oils can assist in precisely pinpointing the sources of contamination and taking the necessary steps to decrease PFAS contamination and thereby safeguard human health. By recognising the sources of contamination, it is possible to enhance the effectiveness of pollution control, avoid superfluous investments, save resources, and advance sustainable environmental progress.
  • 261
  • 27 Jul 2023
Topic Review
Impact of Radiotherapy on Bone Turnover
Radiotherapy (RT) plays a pivotal role in the oncological management of head and neck cancers (HNC). Radiotherapy is the only curative alternative for patients with early-stage squamous cell HNC who are medically inoperable. It is also the only option for inoperable locally advanced salivary gland carcinomas where effective chemotherapy alternatives are not accessible. Locally advanced HNC (LA-HNC) patients may benefit from RT as an adjuvant therapeutic option after surgery and as the backbone of organ-sparing treatment when combined with concurrent chemotherapy. Furthermore, RT can be an effective primary palliative strategy for recurrent or metastatic disease.
  • 260
  • 06 May 2023
Topic Review
Strategies to Manage an Outbreak for Avian Influenza
Avian influenza (AI) is a contagious disease among the poultry population with high avian mortality, which generates significant economic losses and elevated costs for disease control and outbreak eradication. AI is caused by an RNA virus part of the Orthomyxoviridae family; however, only Influenzavirus A is capable of infecting birds. AI pathogenicity is based on the lethality, signs, and molecular characteristics of the virus. Low pathogenic avian influenza (LPAI) virus has a low mortality rate and ability to infect, whereas the highly pathogenic avian influenza (HPAI) virus can cross respiratory and intestinal barriers, diffuse to the blood, damage all tissues of the bird, and has a high mortality rate.
  • 257
  • 26 Apr 2023
Topic Review
Post-Traumatic Stress Disorder in Adolescents
Trauma in childhood and adolescence has long-term negative consequences in brain development and behavior and increases the risk for psychiatric disorders. Among them, post-traumatic stress disorder (PTSD) during adolescence illustrates the connection between trauma and substance misuse, as adolescents may utilize substances to cope with PTSD.
  • 256
  • 04 Dec 2023
Topic Review
Spectrum of Bisphenols and Phthalates as Endocrine Disruptors
Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of physical exercise, data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates and their analogs, and obesity. EDCs represent a heterogeneous group of chemicals that may influence the hormonal regulation of body mass and adipose tissue morphology.
  • 256
  • 10 Jan 2024
Topic Review
Application of Staphylococcus aureus Vaccines
Staphylococcus aureus, a prevalent human pathogen and a leading cause of hospital-acquired infections, is increasingly evolving antibiotic-resistant strains, increasing mortality and morbidity rates. Anti-staphylococcal vaccine research for prevention and treatment has become a priority. Antibodies against specific S. aureus components, toxins, and polysaccharides have demonstrated encouraging results in animal studies regarding protection against colonization or infection. However, human immunization trials have yielded less optimistic outcomes, with no anti-staphylococcal having passed clinical trials up to now. Although multiple formulation attempts triggered strong antibody responses, the vaccines could not effectively prevent S. aureus infections.
  • 256
  • 06 Mar 2024
Topic Review
Racial and Ethnic Disparities in Community-Based Pharmacies
As pharmacy practice shifts its focus toward population health care needs that serve public health, there is a need to understand community-based pharmacies’ contributions to the reduction in health disparities.
  • 255
  • 16 Jun 2023
Topic Review
Pets as Sentinels for Environmental Pollution
Sentinels are organisms whose characteristics (including health status) change due to acute or chronic effects in a given environment that can be evaluated (monitored) through serial surveillance. 
  • 255
  • 26 Sep 2023
Topic Review
Aortic Valve Stenosis and Cancer
Aortic valve stenosis and malignancy frequently coexist and share the same risk factors as atherosclerotic disease. Data reporting the prognosis of patients with severe aortic stenosis and cancer are limited. Tailoring the correct and optimal care for cancer patients with severe aortic stenosis is complex.
  • 255
  • 18 Sep 2023
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