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Topic Review
Primary Localized Cutaneous Nodular Amyloidosis and Sjögren’s Syndrome
Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare condition attributed to plasma cell proliferation and the deposition of immunoglobulin light chains in the skin without association with systemic amyloidosis or hematological dyscrasias. It is not uncommon for patients diagnosed with PLCNA to also suffer from other auto-immune connective tissue diseases, with Sjögren’s syndrome (SjS) showing the strongest association. 
  • 336
  • 06 May 2023
Topic Review
Primary Aldosteronism
Primary aldosteronism, mainly caused by aldosterone producing adenomas or bilateral adrenal hyperplasia,  is the most common cause of endocrine hypertension. Information on the role of transcriptomics, epigenetics and metabolomics in the pathophysiology of this disease is summarized herein.
  • 555
  • 23 Dec 2021
Topic Review
Primal Therapy
Primal therapy is a trauma-based psychotherapy created by Arthur Janov, who argues that neurosis is caused by the repressed pain of childhood trauma. Janov argues that repressed pain can be sequentially brought to conscious awareness and resolved through re-experiencing specific incidents and fully expressing the resulting pain during therapy. In therapy, the patient recalls and reenacts a particularly disturbing past experience usually occurring early in life and expresses normally repressed anger or frustration especially through spontaneous and unrestrained screams, hysteria, or violence. Primal therapy was developed as a means of eliciting the repressed pain; the term Pain is capitalized in discussions of primal therapy when referring to any repressed emotional distress and its purported long-lasting psychological effects. Janov criticizes the talking therapies as they deal primarily with the cerebral cortex and higher-reasoning areas and do not access the source of Pain within the more basic parts of the central nervous system. Primal therapy is used to re-experience childhood pain—i.e., felt rather than conceptual memories—in an attempt to resolve the pain through complete processing and integration, becoming real. An intended objective of the therapy is to lessen or eliminate the hold early trauma exerts on adult behaviour. Primal therapy became very influential during a brief period in the early 1970s, after the publication of Janov's first book, The Primal Scream. It inspired hundreds of spin-off clinics worldwide and served as an inspiration for many popular cultural icons. Singer-songwriter John Lennon, actor James Earl Jones, and pianist Roger Williams were prominent advocates of primal therapy. Primal therapy has since declined in popularity, partly because Janov had not demonstrated in research the outcomes necessary to convince research-oriented psychotherapists of its effectiveness. Proponents of the methodology continue to advocate and practice the therapy or variations of it.
  • 1.7K
  • 23 Nov 2022
Topic Review
Premature Aging in CKD
The characteristics of CKD (chronic kidney disease) are similar to those of the aging process; therefore, it has been hypothesized that CKD promotes premature aging associated with related diseases. Furthermore, chronic diseases usually observed in aging, such as CVD, inflammation, vascular calcification, mineral, and bone disorders, and chronodisruption (chronic alteration of circadian rhythms), are markedly frequent in patients with CKD.
  • 488
  • 04 Aug 2021
Topic Review
Precision Health Care for Diabetes
Tailoring integrated care through interdisciplinary collaborative practice among patients, nurses, and physicians based on the patient’s genetics or lifestyle, glycemic target, biodata- or evidence-based practice, patient preferences, and priority for improving patient self-management to achieve glycemic control.
  • 547
  • 21 Jun 2021
Topic Review
Possible Evolutionary Origin of Alzheimer’s Disease
The enormous, 2–3-million-year evolutionary expansion of hominin neocortices to the current enormity enabled humans to take over the planet. However, there appears to have been a glitch, and it occurred without a compensatory expansion of the entorhinal cortical (EC) gateway to the hippocampal memory-encoding system needed to manage the processing of the increasing volume of neocortical data converging on it. The resulting age-dependent connectopathic glitch was unnoticed by the early short-lived populations. It has now surfaced as Alzheimer’s disease (AD) in today’s long-lived populations. With advancing age, processing of the converging neocortical data by the neurons of the relatively small lateral entorhinal cortex (LEC) inflicts persistent strain and high energy costs on these cells. This may result in their hyper-release of harmless Aβ1–42 monomers into the interstitial fluid, where they seed the formation of toxic amyloid-β oligomers (AβOs) that initiate AD. At the core of connectopathic AD are the postsynaptic cellular prion protein (PrPC). Electrostatic binding of the negatively charged AβOs to the positively charged N-terminus of PrPC induces hyperphosphorylation of tau that destroys synapses. The spread of these accumulating AβOs from ground zero is supported by Aβ’s own production mediated by target cells’ Ca2+-sensing receptors (CaSRs).
  • 178
  • 05 Jul 2023
Topic Review
Positive Psychotherapy
Positive psychotherapy (PPT after Peseschkian, since 1977)TM is a psychotherapeutic method developed by psychiatrist Nossrat Peseschkian and co-workers in Germany beginning in 1968. It can be described as a humanistic psychodynamic psychotherapy, which is based on a positive conception of human nature. The focus of positive psychotherapy is to enhance the positive emotion and engagement of patients rather than targeting the depressive symptoms PPT is an integrative method which includes humanistic, systemic, psychodynamic and CBT-elements. Today there are centers and trainings in some twenty countries worldwide. It should not be confused with positive psychology.
  • 1.7K
  • 22 Nov 2022
Topic Review
Polyphenolic Compounds of Seaweed
The disease-preventive and medicinal properties of plant polyphenolic compounds have long been known. As active ingredients, they are used to prevent and treat many noncommunicable diseases. In recent decades, marine macroalgae have attracted the attention of biotechnologists and pharmacologists as a promising and almost inexhaustible source of polyphenols. This heterogeneous group of compounds contains many biopolymers with unique structure and biological properties that exhibit high anti-infective activity. In the present review, the authors focus on the antiviral potential of polyphenolic compounds (phlorotannins) from marine algae and consider the mechanisms of their action as well as other biological properties of these compounds that have effects on the progress and outcome of viral infections. 
  • 921
  • 28 Mar 2021
Topic Review
Polymeric Nanoparticles for Cancer Treatment
Over the last decade, polymeric NPs have been designed to overcome the limitations of free therapeutics for the treatment of cancer. Polymeric NPs have shown a more favorable pharmacokinetic profile than the free chemotherapeutics, but optimization of the formulation, in terms of the polydispersity and size of the NPs, is still needed to improve efficacy. In the same way, drug release from polymeric NPs can be more precisely controlled, with a range of polymers designed specifically for that purpose.
  • 562
  • 16 Sep 2021
Topic Review
Placental Abruption
Placental abruption is the separation of the placenta from the lining of the uterus before childbirth. It is an infrequent perinatal complication with serious after-effects and a marked risk of maternal and fetal mortality. Despite the fact that numerous placental abruption risk factors are known, the pathophysiology of this issue is multifactorial and not entirely clear.
  • 612
  • 02 Jul 2021
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