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Topic Review
Sotai
Sotai or Sotai-hō (操体法, Sōtai-hō) is a Japan ese form of muscular or movement therapy invented by Keizo Hashimoto (1897–1993), a Japanese medical doctor from Sendai. The term So-tai (操体) is actually the opposite of the Japanese word for exercise: Tai-so (体操). Dr. Hashimoto conceived Sotai as an antidote to the forceful and regimented exercises of Japan, that anyone could practice easily to restore balance and health. Sotai is different from regular exercise because it distinguishes between balanced movements that are natural and beneficial and those that are unnatural and cause strains and physical distortions. The aim of Sotai is to help the body restore and maintain its natural balance. Dr. Hashimoto developed a model of treatment based on restoring structural balance that is claimed to work with the breath and movements toward comfort (or away from pain). He developed Sotai Therapy from traditional East Asian medicine (acupuncture, moxibustion, bone setting (Sekkotsu), Seitai Jutsu) in concert with his knowledge of modern medicine. Sotai Therapy is intended to be a method of neuromuscular reeducation and unwinding muscular holding patterns. According practitioners, Sotai Therapy balances the nervous and muscular systems. Its central principle is backtracking movement or "reverse-motion" treatment. The idea is that structural distortions can be returned to a more normal condition by moving the body in the comfortable direction. Using the effects of an isometric contraction followed by a sudden relaxation (post-isometric relaxation) can normalise the strained condition.
  • 1.2K
  • 21 Nov 2022
Topic Review
Cinema Therapy
Cinema therapy or movie therapy is a form of expressive therapy - like art, music and dance therapy - for medical and mental health issues. It is also used as a form of self-help. Cinema therapy was created and popularized by Dr. Gary Solomon, the first to write on using movies as therapy. The movement started to catch up again in 2019 with the featured documentary "Calypsonians" by director Anghelo Taylor, unlike the creation of Dr. Gary Solomon, Anghelo Taylor wrote the CinemaTherapy Manifesto, that starts with one simple principle "In order for cinema therapy truly exist the filmmaker must have an internal search, question or problem to solve inside himself but that relates with the rest of humanity or with specific community. Once the filmmaker and his crew engage in the process of filmmaking, they start healing by the revelation and situations that happen along the process of making a film. In the end, the result of that process will be a medicine for all the viewers as human beings. But everything starts with the deep intention that the filmmaker has when making the film"
  • 1.2K
  • 23 Nov 2022
Topic Review
Parenteral Nutrition and Sepsis
Parenteral nutrition (PN) is recommended in malnourished patients or those at risk of malnutrition in some conditions—such as gut functional unavailability or gut physical inaccessibility. The lipids are sepsis risk factors in patients receiving parenteral nutrition. 
  • 1.2K
  • 29 Jul 2022
Topic Review
Anticancer Plants
The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This entry reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their regulatory aspects. This study is based on a meticulous literature review conducted through the search of relevant keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty plants were selected based on defined selection criteria for their potent anticancer compounds. The detailed analysis of the research studies revealed that plants play an indispensable role in fighting different cancers such as breast, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-inducing enzymes by the secondary metabolites in the plant extracts. Studies that reported in vivo activities of these plants showed remarkable results in the inhibition of cancer in animal models. 
  • 1.2K
  • 26 Jul 2021
Topic Review
Developmental Origins of Health and Disease (DOHaD) Hypothesis
The “developmental origins of health and disease” (DOHaD) hypothesis refers to the influence of early developmental exposures and fetal growth on the risk of chronic diseases in later periods. 
  • 1.2K
  • 11 Feb 2022
Topic Review
Mitochondrial Dysfunction
Mitochondrial dysfunction results in a series of defective cellular events, including decreased adenosine triphosphate (ATP) production, enhanced reactive oxygen species (ROS) output, and altered proteastasis and cellular quality control. An enhanced output of ROS may damage mitochondrial components, such as mitochondrial DNA and elements of the electron transport chain, resulting in the loss of proper electrochemical gradient across the mitochondrial inner membrane and an ensuing shutdown of mitochondrial energy production. Neurons have an increased demand for ATP and oxygen, and thus are more prone to damage induced by mitochondrial dysfunction. Mitochondrial dysfunction, damaged electron transport chains, altered membrane permeability and Ca2+ homeostasis, and impaired mitochondrial defense systems induced by oxidative stress, are pathological changes involved in neurodegenerative disorders. A growing body of evidence suggests that the use of antioxidants could stabilize mitochondria and thus may be suitable for preventing neuronal loss. Numerous natural products exhibit the potential to counter oxidative stress and mitochondrial dysfunction; however, science is still looking for a breakthrough in the treatment of neurodegenerative disorders. β-caryophyllene is a bicyclic sesquiterpene, and an active principle of essential oils derived from a large number of spices and food plants. As a selective cannabinoid receptor 2 (CB2) agonist, several studies have reported it as possessing numerous pharmacological activities such as antibacterial (e.g., Helicobacter pylori), antioxidant, anti-inflammatory, analgesic (e.g., neuropathic pain), anti-neurodegenerative and anticancer properties. The present review mainly focuses on the potential of β-caryophyllene in reducing oxidative stress and mitochondrial dysfunction, and its possible links with neuroprotection. 
  • 1.2K
  • 29 Apr 2021
Topic Review
Anti-Inflammatory and Antiviral Effects of Cannabinoids
The COVID-19 pandemic caused by the SARS-CoV-2 virus made it necessary to search for new options for both causal treatment and mitigation of its symptoms. Scientists and researchers around the world are constantly looking for the best therapeutic options. These difficult circumstances have also spurred the re-examination of the potential of natural substances contained in Cannabis sativa L. Cannabinoids, apart from CB1 and CB2 receptors, may act multifacetedly through a number of other receptors, such as the GPR55, TRPV1, PPARs, 5-HT1A, adenosine and glycine receptors. The complex anti-inflammatory and antiviral effects of cannabinoids have been confirmed by interactions with various signaling pathways. Considering the fact that the SARS-CoV-2 virus causes excessive immune response and triggers an inflammatory cascade, and that cannabinoids have the ability to regulate these processes, it can be assumed that they have potential to be used in the treatment of COVID-19.
  • 1.1K
  • 22 Apr 2022
Topic Review
Eidetic Imagery
An eidetic image is a type of vivid mental image, not necessarily derived from an actual external event or memory. It was identified in the early twentieth century as a distinct phenomenon by psychologists including E.R. Jaensch, Heinrich Klüver, Gordon Allport and Frederic Bartlett. Later, Akhter Ahsen located eidetic imagery in a structuralist context, and explored its therapeutic applications: psychotherapists sometimes encourage their clients to create and explore eidetic images as a way of coming to terms with past life events. Eidetic imagery has also been studied in relation to the creative arts.
  • 1.1K
  • 21 Oct 2022
Topic Review
Fish by-products,Bioactive Peptide-Rich Protein Hydrolysates
The use of fish by-products is an important production opportunity for the fishing and seafood processing industries since it can possibly create additional profits while also lowering disposal costs. Benefits of utilizing secondary raw materials from fish processing are depicted in. One of the potential possibilities for greater benefit is to use these industrial wastes and low-value fish for the recovery and hydrolysis of proteins rich in bioactive peptides.
  • 1.1K
  • 16 Sep 2021
Topic Review
2LARTH® Micro-Immunotherapy Treatment
Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are two cytokines involved in the perpetuation of the chronic inflammation state characterizing rheumatoid arthritis (RA). Significant advances in the treatment of this pathology have been made over the past ten years, partially through the development of anti-TNF and anti-IL-1 therapies. However, major side effects still persist and new alternative therapies should be considered.
  • 1.1K
  • 19 Nov 2021
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