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Topic Review
Direct Type Electrochemical Glycated Hemoglobin Sensors
Glycated hemoglobin (HbA1c) is the gold standard for measuring glucose levels in the diagnosis of diabetes due to the excellent stability and reliability of this biomarker. HbA1c is a stable glycated protein formed by the reaction of glucose with hemoglobin (Hb) in red blood cells, which reflects average glucose levels over a period of two to three months without suffering from the disturbance of the outside environment. A number of simple, high-efficiency, and sensitive electrochemical sensors have been developed for the detection of HbA1c. Direct type sensors determine HbA1c by detecting the changes in electrical signals including current, potential, and impedance before and after HbA1c is bound to biological affinity molecules pre-fixed on the electrode surface. Direct sensors are divided into amperometric sensors, potentiometric sensors, and impedimetric sensors.
  • 557
  • 22 Apr 2022
Topic Review
Protein Caging Tools for Protein Photoactivation
In biosciences and biotechnologies, it is recently critical to promote research regarding the regulation of the dynamic functions of proteins of interest. Light-induced control of protein activity is a strong tool for a wide variety of applications because light can be spatiotemporally irradiated in high resolutions. Therefore, synthetic, semi-synthetic, and genetic engineering techniques for photoactivation of proteins have been actively developed. As a solution for overcoming barriers in conventional ones, researchers' recent approaches in which proteins were chemically modified with biotinylated caging reagents are introduced to photo-activate a variety of proteins without genetic engineering and elaborate optimization.
  • 643
  • 21 Apr 2022
Topic Review
Indirect Type Electrochemical Glycated Hemoglobin Sensors
Glycated hemoglobin (HbA1c) is the gold standard for measuring glucose levels in the diagnosis of diabetes due to the excellent stability and reliability of this biomarker. HbA1c is a stable glycated protein formed by the reaction of glucose with hemoglobin (Hb) in red blood cells, which reflects average glucose levels over a period of two to three months without suffering from the disturbance of the outside environment. A number of simple, high-efficiency, and sensitive electrochemical sensors have been developed for the detection of HbA1c. Indirect type electrochemical HbA1c sensors work based on the measurement of fructosyl valine/fructosyl valine histidine (FV or FVH), which is a form of enzymatic determination. According to the type of enzymes, indirect sensors are divided into fructosyl amino acid oxidase (FAO) type, fructosyl peptide oxidase (FPOX) type, and molecularly imprinted catalyst (MIC) type sensors. These enzymes usually need to be processed with nanotechnology or imprinting technology to immobilize them on the electrode surface. 
  • 450
  • 21 Apr 2022
Topic Review
Lung-Cancer-Related Exhaled Breath Biomarkers
Lung cancer has been studied for decades because of its high morbidity and high mortality. Traditional methods involving bronchoscopy and needle biopsy are invasive and expensive, which makes patients suffer more risks and costs. Various noninvasive lung cancer markers, such as medical imaging indices, volatile organic compounds (VOCs), and exhaled breath condensates (EBCs), have been discovered for application in screening, diagnosis, and prognosis. However, the detection of markers still relies on bulky and professional instruments, which are limited to training personnel or laboratories. This seriously hinders population screening for early diagnosis of lung cancer. Advanced smartphones integrated with powerful applications can provide easy operation and real-time monitoring for healthcare, which demonstrates tremendous application scenarios in the biomedical analysis region from medical institutions or laboratories to personalized medicine.
  • 384
  • 21 Apr 2022
Topic Review
Camelids' Milk
Camel milk has always represented an important food for nomadic people in the arid parts of the world; recently, camel milk attracted great attention as a possible replacer to dairy cow’s milk because of its therapeutic effects. The use of alternative milk for feeding children can be effective in reducing the development of gastrointestinal disorders.
  • 667
  • 19 Apr 2022
Topic Review
Hop Phenolic Compounds on Dry Hopping Beer Quality
The study considers the phenolic hop compounds’ effect on the quality indicators of finished beer. The topic under consideration is relevant since it touches on the beer matrix colloidal stability when compounds with potential destabilizing activity are introduced into it from the outside.
  • 495
  • 19 Apr 2022
Topic Review
Aggregation-Induced Emission Active Materials
The emergence and development of aggregation induced emission (AIE) have attracted worldwide attention due to its unique photophysical phenomenon and for removing the obstacle of aggregation-caused quenching (ACQ) which is the most detrimental process thereby making AIE an important and promising aspect in various fields of fluorescent material, sensing, bioimaging, optoelectronics, drug delivery system, and theranostics. hexaphenylsilole (HPS) is the common example of the AIE active molecule which exhibits enhancement in fluorescence in an aggregate state. The motions involved, such as restriction of intramolecular motion along with rotation and vibration mechanisms in the AIE active phenomenon, are well explained and accepted. The AIE luminogens have high photostability, large stoke shift, a photobleaching resistance property, and show high sensing reproducibility. This characteristic makes luminogens a promising candidate for sensing application
  • 1.3K
  • 19 Apr 2022
Topic Review
Synthesis of Quantum Dots, Polymer, and Nanocomposites
Owing to the nanometer size range, Quantum Dots (QDs) have exhibited unique physical and chemical properties which are favourable for different applications. Especially, due to their quantum confinement effect, excellent optoelectronic characteristics is been observed. This considerable progress has not only uplifted the singular usage of QDs, but also encouraged to prepare various hybrid materials to achieve superior efficiency by eliminating certain shortcomings. Such issues can be overcome by compositing QDs with polymers. 
  • 728
  • 14 Apr 2022
Topic Review
Starch-Based Biodegradable Films for Food Packaging
The use of biodegradable packaging material as an alternative to conventional petrochemical-based polymers is based on the environmental issues associated with conventional materials. Starch-based biodegradable films can be applied in food packaging. It was evident that starch stands out among biopolymers due to its abundance and cost effectiveness.
  • 2.7K
  • 07 Apr 2022
Topic Review
Pectin–Zeolite-Based Wound Dressings with Controlled Albumin Release
Hypoalbuminemia is a disorder caused by low albumin production rates or an increased loss due to several possible reasons. Hypoalbuminemia can lead to poor and delayed wound healing, while it is also associated with acute myocardial infarction, heart failure, malignancies, and COVID-19. In elective surgery, patients with low albumin have high risks of postoperative wound complications. 
  • 370
  • 29 Mar 2022
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