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Topic Review
Cardiac Involvement in Hereditary Hemochromatosis
Hereditary hemochromatosis (HH) is a genetic disease leading to excessive iron absorption, its accumulation, and oxidative stress induction causing different organ damage, including the heart. The process of cardiac involvement is slow and lasts for years. Cardiac pathology manifests as an impaired diastolic function and cardiac hypertrophy at first and as dilatative cardiomyopathy and heart failure with time. From the moment of heart failure appearance, the prognosis is poor. Therefore, it is crucial to prevent those lesions by upfront therapy at the preclinical phase of the disease. The most useful diagnostic tool for detecting cardiac involvement is echocardiography. However, during an early phase of the disease, when patients do not present severe abnormalities in serum iron parameters and severe symptoms of other organ involvement, heart damage may be overlooked due to the lack of evident signs of cardiac dysfunction. Considerable advancement in echocardiography, with particular attention to speckle tracking echocardiography, allows detecting discrete myocardial abnormalities and planning strategy for further clinical management before the occurrence of substantial heart damage. 
  • 889
  • 19 Aug 2021
Topic Review
Mucociliary clearance
Mucociliary clearance constitutes an innate lung defense mechanism that is primarily driven by ciliated cells. Respiratory mucus traps pathogens entering the airways, and lung cilia propel them outward via their coordinated directional motion. Thus, damage to the component(s) of this apparatus is averted and physiological function is ensured. 
  • 891
  • 30 Sep 2021
Topic Review
Dietary Polyphenols' Biopharmaceutical Classification System
Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. 
  • 888
  • 17 Jun 2021
Topic Review
Respiratory System Related Organ-on-a-Chip Models
The development of microfluidic chip technology provides a technical platform for better research on respiratory diseases. The size of its microchannel can be similar to the space for cell growthin vivo. In addition, organ-on-a-chip can achieve long-term co-cultivation of multiple cells and produce precisely controllable fluid shear force, periodically changing mechanical force, and perfusate with varying solute concentration gradient. To sum up, the chip can be used to analyze the specific pathophysiological changes of organs meticulously, and it is widely used in scientific research on respiratory diseases.
  • 888
  • 27 Oct 2021
Topic Review
Iconic Memory
Iconic memory is the visual sensory memory register pertaining to the visual domain and a fast-decaying store of visual information. It is a component of the visual memory system which also includes visual short-term memory (VSTM) and long-term memory (LTM). Iconic memory is described as a very brief (
  • 888
  • 07 Oct 2022
Topic Review
Zoopharmacology
Zoopharmacognosy is the multidisciplinary approach of the self-medication behavior of many kinds of animals. Recent studies showed the presence of antitumoral secondary metabolites in some of the plants employed by animals and their use for the same therapeutic purposes in humans. Other related and sometimes confused term is Zootherapy, which consists on the employment of animal parts and/or their by-products such as toxins, venoms, etc., to treat different human ailments. Therefore, the aim of this work is to provide a brief insight for the use of Zoopharmacology (comprising Zoopharmacognosy and Zootherapy) as new paths to discover drugs studying animal behavior and/or using compounds derived from animals.
  • 889
  • 28 Jun 2021
Biography
Jonathan Downes
Jonathan Downes (born 1959) is a naturalist, cryptozoologist, author, editor, film-maker, poet, novelist, activist, journalist, composer and singer-songwriter, with a background in radical politics and mental health care. He is Director of the Centre for Fortean Zoology. His father, the explorer and Colonial Service Officer J. T. Downes (1925–2006), wrote several books on a wide range of subje
  • 889
  • 28 Nov 2022
Biography
Claude Pouillet
Claude Servais Mathias Pouillet (16 February 1790 – 14 June 1868) was a France physicist and a professor of physics at the Sorbonne and member of the French Academy of Sciences (elected 1837). He studied sciences at the École normale supérieure (Paris), and from 1829 to 1849 was associated with the Conservatoire national des arts et métiers, first as a professor, and beginning in 1832, a
  • 888
  • 24 Nov 2022
Topic Review
HGPS and Cardiovascular Disease
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that recapitulates many symptoms of physiological aging and precipitates death. Patients develop severe vascular alterations, mainly massive vascular smooth muscle cell loss, vessel stiffening, calcification, fibrosis, and generalized atherosclerosis, as well as electrical, structural, and functional anomalies in the heart. As a result, most HGPS patients die of myocardial infarction, heart failure, or stroke typically during the first or second decade of life. No cure exists for HGPS, and therefore it is of the utmost importance to define the mechanisms that control disease progression in order to develop new treatments to improve the life quality of patients and extend their lifespan. Since the discovery of the HGPS-causing mutation, several animal models have been generated to study multiple aspects of the syndrome and to analyze the contribution of different cell types to the acquisition of the HGPS-associated cardiovascular phenotype.
  • 888
  • 22 Sep 2021
Topic Review
Hybrid Schistosomes in Africa
Causal agents of schistosomiasis are dioecious, digenean schistosomes affecting mankind in 76 countries.  Natural and anthropogenic changes impact on breaking species isolation barriers favoring introgressive hybridization, i.e., allelic exchange among gene pools of sympatric, interbreeding species leading to instant large genetic diversity. Phylogenetic distance matters, thus the less species differ phylogenetically the more likely they hybridize. 
  • 888
  • 28 Jul 2021
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