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Topic Review
Inhibition of Multidrug Efflux Pumps in Bacterial Pathogens
Of the various bacterial mechanisms for antimicrobial resistance, active efflux is a well-known system that extrudes clinically relevant antimicrobial agents, rendering specific pathogens recalcitrant to the growth-inhibitory effects of multiple drugs. In particular, multidrug efflux pump members of the major facilitator superfamily (MFS) constitute central resistance systems in bacterial pathogens. MFS efflux confer resistance to multiple antimicrobial agents and are thus excellent targets for inhibition. Several efflux pump inhibitors (EPIs) of natural origin have been shown to possess efflux pump inhibition activities and could potentially be used to restore the efficacy of antibacterial drugs. 
  • 587
  • 29 May 2023
Topic Review
Effects of Microbial Feed Additives on Ornamental Fish
Trade of ornamental fish has significantly increased. A rise in demand was observed, especially from top importing countries that contributed majorly to the growth of the market. Thus, there is a need to improve ornamental fish aquaculture, increasing the number of cultured species and limiting wild fish handling and transport stress losses. The use of microbial feed additives such as probiotics, prebiotics, and synbiotics, could help in improving the immune system and growth as well as increasing reproductive performance in captivity-bred species.
  • 635
  • 29 May 2023
Topic Review
Mesenchymal-Stromal-Cell-Conditioned Media
Despite significant advances in biomedical research, osteochondral defects resulting from injury, an autoimmune condition, cancer, or other pathological conditions still represent a significant medical problem. Cell-based therapies and tissue engineering have gradually become promising alternatives. They combine the use of different types of cells and biomaterials to induce regeneration processes or replace damaged osteochondral tissue. One of the main challenges of this approach before clinical translation is the large-scale in vitro expansion of cells without changing their biological properties, while the use of conditioned media which contains various bioactive molecules appears to be very important.
  • 321
  • 28 May 2023
Topic Review
Lipidomics in Human Brain
One of the richest tissues in lipid content and diversity of the human body is the brain. Glycerophospholipids are the main lipid category widely distributed in neural cell membranes, with a very significant presence for the ether lipid subclass. Ether lipids have played a key role in the evolution of the human brain compositional specificity and functionality. Ether lipids determine the neural membrane structural and functional properties, membrane trafficking, cell signaling and antioxidant defense mechanisms. 
  • 444
  • 28 May 2023
Topic Review
Gut-to-Brain α-Synuclein Transmission in Parkinson’s Disease
Parkinson’s disease (PD) is a multifactorial disorder involving both motor and non-motor symptoms caused by the progressive death of distinct neuronal populations, including dopaminergic neurons in the substantia nigra. The deposition of aggregated α-synuclein protein into Lewy body inclusions is a hallmark of the disorder, and α-synuclein pathology has been found in the enteric nervous system (ENS) of PD patients up to two decades prior to diagnosis. In combination with the high occurrence of gastrointestinal dysfunction in early stages of PD, evidence strongly suggests that some forms of PD may originate in the gut. 
  • 388
  • 26 May 2023
Topic Review
Heterologous Synthesis of Xanthophyll in Model Microorganisms
Xanthophyll is an oxidated version of carotenoid. It presents significant value to the pharmaceutical, food, and cosmetic industries due to its specific antioxidant activity and variety of colors. Chemical processing and conventional extraction from natural organisms are still the main sources of xanthophyll. 
  • 707
  • 26 May 2023
Topic Review
Cancer Cell Secretome in Driving Breast Cancer Progression
Breast cancer is a complex disease that remains a significant public health challenge. The breast cancer cells secrete various substances collectively known as the secretome, which include proteins, lipids, and nucleic acids that contribute to the growth and spread of breast cancer. The secretome plays a crucial role in the development and progression of breast cancer by modifying signaling pathways and creating an environment supporting cancer growth while evading the immune system. Additionally, the secretome is responsible for the development of resistance to cancer drugs, making it a significant challenge for effective treatment.
  • 357
  • 26 May 2023
Topic Review
Omics Technologies in the Study of Fruit-Elicitor Interaction
Fruit losses and wastage are mainly due to postharvest diseases; their control is reduced with pesticides. The excessive use of synthetic fungicides has caused harmful effects on human health and the environment, so it is therefore necessary to reduce their use. The development of new innocuous strategies has led to the use of compounds of natural or biological origin with the capacity to induce the plant defense system, which improves the fruit’s response against future pathogen attacks in addition to reducing the incidence of postharvest diseases. These compounds are known as “elicitors”. Although the use of molecular tools such as RT-qPCR or the measurement of the enzymatic activity of molecular markers makes it possible to determine the activation of the plant defense system in response to the application of an elicitor compound, omics technologies such as the transcriptome, proteome, or metabolome have provided new and interesting information that helps to elucidate the molecular aspects involved in the activation of the plant defense system in response to the application of elicitors.
  • 357
  • 26 May 2023
Topic Review
Extraction Techniques of Bioactive Compounds
Fruit wastes and/or by-products that food agro-industries accumulate are typically made up of underutilized residual biomasses that are rich in various bioactive functional components. Fruit wastes have been researched for the extraction of phenolic compounds, dietary fibers, and other bioactive substances, as they are rich sources of phytochemicals. Fruit and vegetable wastes from the agri-food sector are produced in enormous quantities and, due to their high moisture content and microbial load, can lead to significant environmental damage. Bioactive components could degrade quickly, even with the slightest alterations in extraction techniques. Therefore, it is necessary to ensure conditions that will stabilize the bioactive components before and after extraction. Choosing an appropriate optimized extraction technique is critical as it decides the final quality of the bioactive compound.
  • 602
  • 26 May 2023
Topic Review
Association between Microplastics and Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) has emerged as the predominant cause of chronic liver injury; however, the mechanisms underlying its progression have not been fully elucidated. Pathophysiological studies have stated that NAFLD is significantly influenced by dietary and environmental factors that could participate in the development of NAFLD through different mechanisms. “Plastic pollution” is one of the most challenging environmental problems worldwide since several plastics have potential toxic or endocrine disputing properties. Specifically, the intake of microplastics (MPs) and nanoplastics (NPs) in water or diet and/or the inhalation from suspended particles is well established, and these particles have been found in human samples. Laboratory animals exposed to MPs develop inflammation, immunological responses, endocrine disruptions, and alterations in lipid and energy metabolism, among other disorders. MPs additives also demonstrated adverse reactions.  Adequate mitigation strategies worldwide, reducing environmental pollution and human exposure levels of MPs, could reduce the risk of NAFLD.
  • 453
  • 26 May 2023
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