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Topic Review
STIM1 for Intracellular Calcium Handling
Stromal interacting molecule 1 (STIM1), a single transmembrane-spanning domain protein mainly residing in the endoplasmic reticulum (ER), is the unique ER Ca2+sensor deputed to ER Ca2+refilling. STIM1 was identified in 2005 by RNA interference-based screening of proteins with known signaling motifs. Molecularly, STIM1, residing into the organelle, senses luminal Ca2+ concentration by its N-terminus with a low affinity with an apparent dissociation constant (Kd) of ~0.2–0.6 mM and interferes with several plasma membrane ionic proteins. In this way, STIM1 coordinates the  complex Ca2+ entry mechanism called store-operated calcium entry (SOCE) deputed to ER Ca2+ recharge.
  • 534
  • 03 Mar 2022
Topic Review
Still’s Disease and Kawasaki Disease
Still’s disease and Kawasaki disease (KD) today belong to the group of cytokine storm syndromes, a pathophysiological set related to excessive activation of the innate immune response. 
  • 664
  • 30 Jul 2021
Topic Review
Stilbenoids
Stilbenoids are well-known phytoalexins in the group of polyphenolic compounds. Because of their potent bioactivities, including antioxidant, antityrosinase, photoprotective, and antibacterial activities, stilbenoids are utilized as pharmaceutical active ingredient in cosmetic products. Thus, the demand for stilbenoids in the cosmetic industry is increasing. 
  • 930
  • 26 Sep 2022
Topic Review
Stilbenes, Phenolic Acids and Tannin Nutraceuticals and Metabolites
Nutraceuticals are generally defined as a food or part of a food that provides benefits to health in addition to its nutritional content. They have been receiving increasing attention due to their potential role as adjuvants against non-communicable chronic diseases (cardiovascular disease, diabetes, cancer, etc.). Positive effects have been reported associated with an average dietary consumption of several nutraceutical classes, meaning that the primary compound might not be solely responsible for all the biological effects. The in vivo activities of such biomolecules might be carried out by metabolites derived from gut microbiota fermentative transformation.
  • 643
  • 13 Jul 2022
Topic Review
Stilbene Biosynthesis
Stilbenes are a small family of polyphenolic secondary metabolites that can be found in several distantly related plant species. These compounds act as phytoalexins, playing a crucial role in plant defense against phytopathogens, as well as being involved in the adaptation of plants to abiotic environmental factors. Among stilbenes, trans-resveratrol is certainly the most popular and extensively studied for its health properties. However, many other stilbenes, both monomeric and oligomeric, are currently under intensive investigation due to their biological role and bioactivity.
  • 4.5K
  • 14 Jan 2021
Topic Review
Stickler syndrome
Stickler syndrome is a group of hereditary conditions characterized by a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems. These signs and symptoms vary widely among affected individuals.  
  • 689
  • 23 Dec 2020
Topic Review
Stewart's Wilt
Stewart's wilt is a serious bacterial disease of corn caused by the bacterium Pantoea stewartii. This bacterium affects plants, particularly types of maize such as sweet, flint, dent, flower, and popcorn. The disease is also known as bacterial wilt or bacterial leaf blight and has shown to be quite problematic in sweet corn. The disease is endemic in the mid-Atlantic and Ohio River Valley regions and in the southern portion of the Corn Belt.
  • 373
  • 04 Nov 2022
Topic Review
Stevens-Johnson Syndrome/toxic Epidermal Necrolysis
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe skin reaction most often triggered by particular medications. Although Stevens-Johnson syndrome and toxic epidermal necrolysis were once thought to be separate conditions, they are now considered part of a continuum. Stevens-Johnson syndrome represents the less severe end of the disease spectrum, and toxic epidermal necrolysis represents the more severe end.  
  • 469
  • 23 Dec 2020
Biography
Steven E. Jones
Steven Earl Jones (born March 25, 1949[1]) is an American physicist. Among scientists, Jones became known for his long research on muon-catalyzed fusion and geo-fusion.[2][3][4] Jones is also known for his association with 9/11 conspiracy theories.[5][6] Jones has claimed that mere airplane crashes and fires could not have resulted in so rapid and complete a fall of the World Trade Center Towers
  • 2.2K
  • 20 Dec 2022
Topic Review
Sterol Hormone 20-Hydroxyecdysone Biosynthesis
20E (20-Hydroxyecdysone) is a central steroid hormone that orchestrates developmental changes and metamorphosis in arthropods. PCD (Programmed cell death), including apoptosis, necrosis, efferocytosis, pyroptosis, ferroptosis, and autophagy, plays a crucial role in regulated cell elimination, which is vital for cells’ development and tissue homeostasis.
  • 191
  • 22 Nov 2023
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