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Topic Review
Sunscreens and UV Protection
Excessive UV (ultraviolet) radiation exposure is harmful to skin cells since sunburn is accompanied by oxidative burst, leading to a rapid increase in skin cancer. However, the insufficient UV photoprotection of approved sunscreens and the negative impact of their compositions on ecosystems and human health makes the utility of sunscreen a questionable recommendation. Therefore, discovering UV filters with significant antioxidant activity and improved topical performance and photostability is an urgent need.
  • 1.0K
  • 17 Mar 2023
Topic Review
Sun Bear
The Sun bear (Helarctos malayanus), also known as the "honey bear," is the smallest bear species and inhabits the dense tropical forests of Southeast Asia. Recognizable by its sleek black fur, distinctive crescent-shaped chest patch, and short muzzle, the Sun bear possesses a unique adaptation: an elongated tongue ideal for extracting honey and insects from tree cavities. Despite its diminutive size, this arboreal omnivore plays a crucial role in forest ecosystems, dispersing seeds and regulating insect populations, while facing threats from habitat loss and poaching for traditional medicine and the pet trade.
  • 296
  • 08 Mar 2024
Topic Review
SUMOylation in Skeletal Development and Disease
The modification of proteins by small ubiquitin-related modifier (SUMO) molecules, SUMOylation, is a key post-translational modification involved in a variety of biological processes, such as chromosome organization, DNA replication and repair, transcription, nuclear transport, and cell signaling transduction. Emerging evidence has shown that SUMOylation regulates the development and homeostasis of the skeletal system.
  • 391
  • 09 Sep 2022
Topic Review
SUMOylation
SUMOylation is a dynamic and essential Post-Translation Modification (PTM) consisting on the conjugation of Small Ubiquitin-like Modifiers (SUMOs) to an acceptor lysine of a substrate protein. SUMOylation predominantly regulates nuclear processes and its dysregulation is associated to diseases including cancer. SUMOs share a similar three-dimensional structure with other Ubiquitin-Like Modifiers (UBLs). However, SUMOs differ due to their flexible N-terminus, which also contains the site for SUMO chain formation. All eukaryotes express at least one SUMO paralogue. Five SUMO family members have been identified in humans (SUMO1, SUMO2, SUMO3, SUMO4, and SUMO5. However, SUMO1, SUMO2, and SUMO3 are the main family members where they are commonly classified as SUMO1 and SUMO2/3 because of the high similarity between mature SUMO2 and SUMO3. All SUMO paralogues are similar in structure but differ in expression levels. SUMO2 is the most abundant family member in mammalian cells. Studies in mice show that the knockout of SUMO2 is embryonic lethal, while SUMO1 and SUMO3 knockout mice were associated to mild phenotypes, possibly because SUMO2 might compensate the loss of either SUMO1 or SUMO3. Similarly to ubiquitination, SUMO is conjugated in a in a 3-step enzymatic cascade that involves a dimeric E1 activating enzyme (SAE1 and SAE2), an E2 conjugating enzyme (Ubc9), and several SUMO E3 enzymes.
  • 591
  • 28 Mar 2022
Topic Review
SUMO System in Plants
Due to their sessile nature, plants are constantly subjected to various environmental stresses such as drought, salinity, and pathogen infections. Post-translational modifications (PTMs), like SUMOylation, play a vital role in the regulation of plant responses to their environment. The process of SUMOylation typically involves an enzymatic cascade containing the activation, (E1), conjugation (E2), and ligation (E3) of SUMO to a target protein. Additionally, it also requires a class of SUMO proteases that generate mature SUMO from its precursor and cleave it off the target protein, a process termed deSUMOylation. It is now clear that SUMOylation in plants is key to a plethora of adaptive responses. How this is achieved with an extremely limited set of machinery components is still unclear. One possibility is that novel SUMO components are yet to be discovered. However, current knowledge indicates that only a small set of enzymes seem to be responsible for the modification of a large number of SUMO substrates. It is yet unknown where the specificity lies within the SUMO system. Although this seems to be a crucial question in the field of SUMOylation studies, not much is known about the factors that provide specificity. In this review, we highlight the role of the localisation of SUMO components as an important factor that can play a vital role in contributing to the specificity within the process. This will introduce a new facet to our understanding of the mechanisms underlying such a dynamic process.
  • 600
  • 17 Feb 2021
Topic Review
SUMF1 Gene
Sulfatase modifying factor 1: The SUMF1 gene provides instructions for making an enzyme called formylglycine-generating enzyme (FGE). 
  • 481
  • 24 Dec 2020
Topic Review
Sulfur in Seeds
Sulfur is a growth-limiting and secondary macronutrient as well as an indispensable component for several cellular components of crop plants. 
  • 1.1K
  • 09 Feb 2022
Topic Review
Sulfur in Plant Defense
Sulfur (S) is an essential plant macronutrient and the pivotal role of sulfur compounds in plant disease resistance has become obvious in recent decades. These compounds include sulfur containing amino acids such as cysteine and methionine, the tripeptide glutathione, thionins and defensins, glucosinolates and phytoalexins and, last but not least, reactive sulfur species and hydrogen sulfide. SDCs play versatile roles both in pathogen perception and initiating signal transduction pathways that are interconnected with various defense processes regulated by plant hormones (salicylic acid, jasmonic acid and ethylene) and reactive oxygen species (ROS). Importantly, ROS-mediated reversible oxidation of cysteine residues on plant proteins have profound effects on protein functions like signal transduction of plant defense responses during pathogen infections. Indeed, the multifaceted plant defense responses initiated by SDCs should provide novel tools for plant breeding to endow crops with efficient defense responses to invading pathogens.
  • 1.2K
  • 17 Dec 2020
Topic Review
Sulfur in Agronomic Biofortification with Essential Micronutrients
Sulfur (S) plays crucial roles, including in the management of the essential micronutrients (EM) metalome. Each of the EM at first exists as a free cation, which is an existence that causes undesirable actions. Efficient handling of the EM metalome requires efficient chelation, transport, and translocation, along with efficient management of these actions. For each one of these management systems toward handling each EM properly, the phytoavailability of EM, along with the proper form of S in place and in time, is of central interest. Moreover, the functional EM metalome of plants is modified by S availability.
  • 315
  • 25 Aug 2022
Topic Review
Sulfur Compounds in the Whisky Production Process
Whisky is produced through malting, mashing, fermentation, distillation, and maturation. During these processes, several sulfur compounds are formed and/or reduced in quantity. To date, alkyl sulfides, thiols, methylthio group compounds, thiophenes, thiazoles, dithiapentane derivatives, and furfuryl compounds have been detected in the final spirit. Distillers might be able to control quality better if the pathways and contributions of these chemicals were known; currently, however, only some of them have been identified, while others remain to be revealed.
  • 2.0K
  • 11 Mar 2022
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