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Topic Review
Molecular Detection of Colorectal Cancer
Drug-specific therapeutic approaches for colorectal cancer (CRC) have contributed to a significant improvement in the health status of patients. However, a great need to improve personalization of treatments based on genetic and epigenetic tumor profiles to maximize quality and efficacy while limiting cytotoxicity remains. Currently, CEA and CA 19-9 are the only validated blood biomarkers in clinical practice. For this reason, laboratories are trying to identify new specific prognostic and, more importantly, predictive biomarkers for CRC patient profiles. Thus, the unique landscape of personalized biomarker data should have a clinical impact on CRC treatment strategies and molecular genetic screening tests should become the standard method for CRC diagnosis, as well as detection of disease progression.
  • 1.4K
  • 30 Apr 2021
Topic Review
Tumor Temperature
The temperature of a solid tumor is often dissimilar to baseline body temperature and, compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of a tumor is dependent on metabolic activity and vascularization and can change due to tumor progression, treatment, or cancer type.
  • 1.4K
  • 13 Sep 2022
Topic Review
Seaweeds as a Fermentation Substrate
The interest in marine macroalgae are increasing  as novel and functional food and feed products. Marine macroalgae show a high flexibility and applicability due to the bioactive properties of the compounds produced. In the nutraceutical sector, the development of novel food products with high nutritious value and sustainable development raises the interest in this biological group.  Indeed, seaweeds mainly need exposure to sun, aeration, artificial or naturally, and seawater rich in nutrients to grow and obtain a high amount of biomass to then develop novel functional food products that can be produced by the fermentation method, mainly performed by lactic acid bacteria. Still, this is a topic that needs to be further developed in order to improve the beneficial and organoleptic  properties of seaweeds.Here is proposed to the potential of prebiotic and probiotic fermentation and the potential of seaweed in food and feed industrial sectors.
  • 1.4K
  • 08 Nov 2021
Topic Review
Nervous Necrosis Virus
Nervous necrosis virus (NNV) can infect many species of fish and caused an 80~100% mortality rate. NNV capsid protein (NNVCP) was the only structural proteins of NNV, but there are few studies on the protein-protein interaction between NNVCP and host cell. Here, we demonstrated 49 proteins in optic nerve tissue that could interact with NNVCP. A new mechanism of NNV morphogenesis is clarified by exploring the interaction between NNVCP and host cells. Moreover, CKB was identified as a novel enhancer for NNV through interacting with NNVCP. These findings may provide more accurate target proteins to understand NNV morphogenesis and provide new insights into the antiviral infection.
  • 1.4K
  • 26 Oct 2020
Topic Review
Updating Phospholipase A2 Biology
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that are subdivided into several distinct families on a structural and biochemical basis. In principle, PLA2 has the capacity to hydrolyze the sn-2 position of glycerophospholipids to release fatty acids and lysophospholipids, yet several enzymes in this superfamily catalyze other reactions rather than or in addition to the PLA2 reaction. PLA2 enzymes play crucial roles in not only the production of lipid mediators, but also membrane remodeling, bioenergetics, and body surface barrier, thereby participating in a number of biological events. Accordingly, disturbance of PLA2-regulated lipid metabolism is often associated with various diseases.
  • 1.4K
  • 17 Nov 2020
Topic Review
Pterocarpus marsupium Roxb. (Fabaceae)
Trees are vital resources for economic, environmental, and industrial growth, supporting human life directly or indirectly through a wide variety of therapeutic compounds, commodities, and ecological services. Pterocarpus marsupium Roxb. (Fabaceae) is one of the most valuable multipurpose forest trees in India and Sri Lanka, as it is cultivated for quality wood as well as pharmaceutically bioactive compounds, especially from the stem bark and heartwood. However, propagation of the tree in natural conditions is difficult due to the low percentage of seed germination coupled with overexploitation of this species for its excellent multipurpose properties. This overexploitation has ultimately led to the inclusion of P. marsupium on the list of endangered plant species. However, recent developments in plant biotechnology may offer a solution to the overuse of such valuable species if such advances are accompanied by technology transfer in the developing world. Specifically, techniques in micropropagation, genetic manipulation, DNA barcoding, drug extraction, delivery, and targeting as well as standardization, are of substantial concern. To date, there are no comprehensive and detailed reviews of P. marsupium in terms of biotechnological research developments, specifically pharmacognosy, pharmacology, tissue culture, authentication of genuine species, and basic gene transfer studies.
  • 1.4K
  • 23 Feb 2022
Topic Review
Fungal Diagnostics
 For invasive fungal infections late diagnosis results in a poor prognosis. This review summarises the current state of the art in diagnostics used in medical mycology and anticipates the emergence of new generations of boiosensors that will provide new opportunities for rapid, sensitive detection of fungal infections.
  • 1.4K
  • 21 Dec 2020
Topic Review
Roles of the CXCL8-CXCR1/2 Axis in Cancer
In humans, Interleukin-8 (IL-8 or CXCL8) is a granulocytic chemokine with multiple roles within the tumor microenvironment (TME), such as recruiting immunosuppressive cells to the tumor, increasing tumor angiogenesis, and promoting epithelial-to-mesenchymal transition (EMT). 
  • 1.4K
  • 29 Mar 2022
Biography
Debasis Mitra
Dr. Debasis Mitra is an Indian Researcher, known for his numerous contributions to the application and formulation of beneficial plant growth-promoting microorganisms at the laboratory and field level for sustainable crop production, protection and development. Dr. Debasis Mitra is currently working as an Assistant Professor (Research) in the Department of Microbiology, Graphic Era (Deemed to be
  • 1.4K
  • 26 Feb 2024
Topic Review
Microcystins
Harmful cyanobacterial blooms pose an environmental health hazard due to the release of water-soluble cyanotoxins. One of the most prevalent cyanotoxins in nature is microcystins (MCs), a class of cyclic heptapeptide hepatotoxins, and they are produced by several common cyanobacteria in aquatic environments. Once released from cyanobacterial cells, MCs are subjected to physical chemical and biological transformations in natural environments. MCs can also be taken up and accumulated in aquatic organisms and their grazers/predators and induce toxic effects in several organisms, including humans.
  • 1.4K
  • 14 Sep 2021
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