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Biography
Thomas Athol Rafter
Thomas Athol Rafter OBE (5 March 1913 – 26 September 1996) was a New Zealand teacher and nuclear chemist. Rafter was born in Wellington, New Zealand in 1913.[1] Although carbon dating was invented in the United States by the chemist Willard Libby, New Zealand scientists played a significant part in its early development. Rafter is internationally recognized as one of the pioneers of the tec
  • 549
  • 16 Dec 2022
Topic Review
Thirteen Potential TMPRSS2 Inhibitors
We identified a set of 13 approved or clinically investigational drugs with positively charged guanidinobenzoyl and/or aminidinobenzoyl groups, including the experimentally verified TMPRSS2 inhibitors Camostat and Nafamostat. Molecular docking suggested that the guanidinobenzoyl or aminidinobenzoyl group in all the drugs could form putative salt bridge interactions with the side-chain carboxyl group of Asp435 located in the S1 pocket of TMPRSS2. Molecular dynamics simulations further revealed the high stability of the putative salt bridge interactions over long-time simulations. These results suggest that the proposed compounds, in addition to Camostat and Nafamostat, could be effective TMPRSS2 inhibitors for COVID-19 treatment by occupying the S1 pocket with the hallmark positively charged groups.
  • 490
  • 12 Jul 2021
Topic Review
Thioxanthenes
Thioxanthenes are one of the three major groups of antipsychotics (the others being phenothiazines and butyrophenones).  Thioxanthene is a chemical compound having a central triple ring structure closely related to one of the other group of antipsychotics (phenothiazines, which also has the triple ring). The major structural difference between the two classes is that the carbon in position 10 in thioxanthenes is replaced by a nitrogen atom in phenothiazines. In thioxanthenes, this C10  shares a double bond with the side chain. Thioxanthenes are represented in two geometric stereoisomers: Z- and E-compounds.
  • 1.7K
  • 24 Jan 2022
Topic Review
Thioredoxin-Related Transmembrane Proteins
The endoplasmic reticulum (ER) is site of synthesis and maturation of membrane and secretory proteins in eukaryotic cells. The ER contains more than 20 members of the Protein Disulfide Isomerase (PDI) family. These enzymes regulate formation, isomerization and disassembly of covalent bonds between cysteine residues. As such, PDIs ensure protein folding, which is required to attain functional and transport-competent structure, and protein unfolding, which facilitates dislocation of defective gene products across the ER membrane for ER-associated degradation (ERAD). The PDI family includes over a dozen of soluble members and few membrane-bound ones. Among these latter, there are five PDIs grouped in the thioredoxin-related transmembrane (TMX) protein family.
  • 720
  • 27 Oct 2020
Topic Review
Thioredoxin-Interacting Protein (TXNIP)
Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is pivotal for the pathophysiology of some diseases. TXNIP increases reactive oxygen species production and oxidative stress and thereby contributes to apoptosis. 
  • 508
  • 02 Jul 2021
Topic Review
Thioredoxin-Interacting Protein
The development of new therapeutic approaches to diseases relies on the identification of key molecular targets involved in amplifying disease processes. One such molecule is thioredoxin-interacting protein (TXNIP), also designated thioredoxin-binding protein-2 (TBP-2), a member of the α-arrestin family of proteins and a central regulator of glucose and lipid metabolism, involved in diabetes-associated vascular endothelial dysfunction and inflammation. TXNIP sequesters reduced thioredoxin (TRX), inhibiting its function, resulting in increased oxidative stress. Many different cellular stress factors regulate TXNIP expression, including high glucose, endoplasmic reticulum stress, free radicals, hypoxia, nitric oxide, insulin, and adenosine-containing molecules. TXNIP is also directly involved in inflammatory activation through its interaction with the nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP3) inflammasome complex. Neurodegenerative diseases such as Alzheimer’s disease have significant pathologies associated with increased oxidative stress, inflammation, and vascular dysfunctions.
  • 573
  • 22 Feb 2021
Topic Review
Thiopurine S-methyltransferase Deficiency
Thiopurine S-methyltransferase (TPMT) deficiency is a condition characterized by significantly reduced activity of an enzyme that helps the body process drugs called thiopurines.
  • 863
  • 23 Dec 2020
Topic Review
Thinning Methods to Regulate Sweet Cherry Crops
In perennial fruit crops, bearing can be influenced by various factors, including environmental conditions, germplasm, rootstocks, and cultivation methods. Cherries, one of the most important and popular fruit species from the temperate climate zone, achieve high prices on the market. New agricultural technologies and environmental factors force a change in the approach to cherry cultivation. Old-type cherry orchards, with their high demand for water, nutrients, and manual work, are replaced by orchards of self-pollinating cherry cultivars grown on dwarf rootstocks. These changes make it necessary to search for ways to regulate fruiting, in particular to thin buds, flower, and fruit. In light of environmental regulations and consumer pressure, thinning methods are being sought that either do not involve the use of chemicals or that use eco-friendly chemical agents.
  • 511
  • 11 Feb 2022
Topic Review
Thin-Layer Chromatography Bioautography
Thin-layer chromatography (TLC) bioautography is a methodological technique that integrates the separation and analysis technology of TLC with biological activity detection technology, which is used to isolate, locate and evaluate the active constituents of natural creatures based on the guidance of activity.
  • 1.8K
  • 06 Aug 2021
Topic Review
Thin Layers (Oceanography)
Thin layers are concentrated aggregations of phytoplankton and zooplankton in coastal and offshore waters that are vertically compressed to thicknesses ranging from several centimeters up to a few meters and are horizontally extensive, sometimes for kilometers. Generally, thin layers have three basic criteria: 1) they must be horizontally and temporally persistent; 2) they must not exceed a critical threshold of vertical thickness; and 3) they must exceed a critical threshold of maximum concentration. The precise values for critical thresholds of thin layers has been debated for a long time due to the vast diversity of plankton, instrumentation, and environmental conditions. Thin layers have distinct biological, chemical, optical, and acoustical signatures which are difficult to measure with traditional sampling techniques such as nets and bottles. However, there has been a surge in studies of thin layers within the past two decades due to major advances in technology and instrumentation. Phytoplankton are often measured by optical instruments that can detect fluorescence such as LIDAR, and zooplankton are often measured by acoustic instruments that can detect acoustic backscattering such as ABS. These extraordinary concentrations of plankton have important implications for many aspects of marine ecology (e.g., phytoplankton growth dynamics, zooplankton grazing, behaviour, environmental effects, harmful algal blooms), as well as for ocean optics and acoustics. Zooplankton thin layers are often found slightly under phytoplankton layers because many feed on them. Thin layers occur in a wide variety of ocean environments, including estuaries, coastal shelves, fjords, bays, and the open ocean, and they are often associated with some form of vertical structure in the water column, such as pycnoclines, and in zones of reduced flow.
  • 413
  • 09 Nov 2022
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