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Biography
Simcha Jacobovici
Simcha Jacobovici (/ˈsɪmxə jəˈkoʊboʊvɪtʃ/, born April 4, 1953, Petah Tikva, Israel) is an Israeli-Canadian film director, producer, freelance journalist, and writer. His parents were from Iași, Romania.[1] Simcha Jacobovici earned a B.A. in Philosophy and Political Science (with honors) from McGill University and an M.A. in International Relations from the University of Toronto. He
  • 1.5K
  • 15 Nov 2022
Topic Review
Nanobodies
Nanobodies are highly water-soluble and stable, have high specificity, and can bind their targets with very high affinity, often in the low nanomolar range. 
  • 1.5K
  • 10 May 2021
Topic Review
Mitochondrial DNA
Increasing evidence implicates mitochondrial dysfunction in the etiology of Parkinson’s disease (PD). Mitochondrial DNA (mtDNA) mutations represent a possible cause and this mechanism might be shared with the aging process and with other age-related neurodegenerative disorders such as Alzheimer’s disease (AD). We have recently proposed a computerized method for mutated mtDNA characterization able to discriminate between AD and aging. Dealing with mtDNA mutation-based profiling of neurodegenerative disease(s), peripheral blood mtDNA sequences from late-onset PD patients and age-matched controls were analyzed and compared to the revised Cambridge Reference Sequence (rCRS). The chaos game representation (CGR) method, modified to visualize heteroplasmic mutations, was used to display fractal properties of mtDNA sequences and fractal lacunarity analysis was applied to quantitatively characterize PD based on mtDNA mutations. Parameter β, from the hyperbola model function of our lacunarity method, was statistically different between PD and control groups when comparing mtDNA sequence frames corresponding to GenBank np 5713-9713. Our original method, based on CGR and lacunarity analysis, represents a useful tool to analyze mtDNA mutations. Lacunarity parameter β is able to characterize individual mutation profile of mitochondrial genome and could represent a promising index to discriminate between PD and aging.
  • 1.5K
  • 29 Oct 2020
Topic Review
Collagen Fibrils
Collagen fibrils are dissected from collagen rich tissues, such as rat tail tendons. Tissue samples such as tendons are sectioned with scalpels and washed with deionized water or phosphate-buffered saline. Subsequently, bundles of collagen fibers are collected with tweezers and then deposited on clean substrates such as microscope glass slides.
  • 1.5K
  • 06 Apr 2022
Topic Review
Sex-Reversed Females of Salmonid Fish
Sex-reversed females (SRFs; masculinised females, neomales) are genetically females; however, owing to masculinisation, they are capable of producing spermatozoa.
  • 1.5K
  • 12 May 2021
Topic Review
Enzymatic Activity
Enzymatic Activity is a sensitive indicator of changes in soil environment, and it changes depending on the farming system. 
  • 1.5K
  • 30 Oct 2020
Topic Review
Old-Field Secondary Succession
Ecological succession to determine how plant communities re-assemble after a natural or anthropogenic disturbance has always been an important topic in ecology.
  • 1.5K
  • 20 May 2021
Topic Review
The Biology of Coral
Coral reefs are portrayed as tropical underwater forests, profusely rich in biodiversity and has immense ecological and economical importance. Apart from other marine calcifying organisms, scleractinian corals are the major biogenic contributor of complex bicarbonate structures. Corals are built from a collective group of tiny transparent organisms known as coral polyps. The increasing impact of natural and anthropogenic factors such as variation in temperature, salinity, cyclones, pollution and so forth have exert direct or direct effects on the coral reef, engendering the phenomenon of coral bleaching with severe outcomes. Coral microbiome comprises of diverse microorganisms including symbiotic algae, which play a determining role in coral physiology, immunity and responsiveness. Further, corals are equipped with sophisticate chemical and biological warfare that is used to their advantage in unfavorable conditions. 
  • 1.5K
  • 17 Jul 2022
Topic Review
Ornithorhynchus
The platypus (Ornithorhynchus anatinus), sometimes referred to as the duck-billed platypus, is a semiaquatic, egg-laying mammal endemic to eastern Australia, including Tasmania. The platypus is the sole living representative or monotypic taxon of its family (Ornithorhynchidae) and genus (Ornithorhynchus), though a number of related species appear in the fossil record. Together with the four species of echidna, it is one of the five extant species of monotremes, mammals that lay eggs instead of giving birth to live young. Like other monotremes, it senses prey through electrolocation. It is one of the few species of venomous mammals, as the male platypus has a spur on the hind foot that delivers a venom, capable of causing severe pain to humans. The unusual appearance of this egg-laying, duck-billed, beaver-tailed, otter-footed mammal baffled European naturalists when they first encountered it, and the first scientists to examine a preserved platypus body (in 1799) judged it a fake, made of several animals sewn together. The unique features of the platypus make it an important subject in the study of evolutionary biology, and a recognisable and iconic symbol of Australia . It is culturally significant to several Aboriginal peoples of Australia, who also used to hunt the animal for food. It has appeared as a mascot at national events and features on the reverse of the Australian twenty-cent coin, and the platypus is the animal emblem of the state of New South Wales. Until the early 20th century, humans hunted the platypus for its fur, but it is now protected throughout its range. Although captive-breeding programs have had only limited success, and the platypus is vulnerable to the effects of pollution, it is not under any immediate threat. (As of 2020), the platypus is a legally protected species in all states where it occurs. It is listed as an endangered species in South Australia and Victoria and has been recommended for listing in New South Wales. The species is classified as a near-threatened species by the IUCN, but a November 2020 report has recommended that it is upgraded to threatened species under the federal EPBC Act, due to habitat destruction and declining numbers in all states.
  • 1.5K
  • 10 Nov 2022
Topic Review
Embryology of Aorta
The aorta is the largest elastic artery in the human body and is classically divided into two anatomical segments, the thoracic and the abdominal aorta, separated by the diaphragm. The thoracic aorta includes the aortic root, the ascending aorta, the arch, and the descending aorta. The aorta’s elastic properties depend on its wall structure, composed of three distinct histologic layers: intima, media, and adventitia. The different aortic segments show different embryological and anatomical features, which account for their different physiological properties and impact the occurrence and natural history of congenital and acquired diseases that develop herein.
  • 1.5K
  • 30 Jun 2023
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