Embryology of Aorta

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This entry is adapted from the peer-reviewed paper 10.3390/diagnostics13132166

The aorta is the largest elastic artery in the human body and is classically divided into two anatomical segments, the thoracic and the abdominal aorta, separated by the diaphragm. The thoracic aorta includes the aortic root, the ascending aorta, the arch, and the descending aorta. The aorta’s elastic properties depend on its wall structure, composed of three distinct histologic layers: intima, media, and adventitia. The different aortic segments show different embryological and anatomical features, which account for their different physiological properties and impact the occurrence and natural history of congenital and acquired diseases that develop herein.

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1. Introduction

The aorta is the largest elastic artery in the human body and is classically divided into two anatomical segments, the thoracic aorta (TA) and the abdominal aorta (AA), separated by the diaphragm. The different segments show distinctive physiological properties reflecting their different anatomical structure and embryology ^[1]. The TA presents higher compliance as compared to the AA and its elastic capacity, especially in the proximal segments, actively contributes to maintaining diastolic pressure and blood flow at the level of peripheral circulation.

The heterogeneous histogenesis of the different segments of the aorta impacts the onset and natural history of congenital and acquired diseases that develop herein. The latter may present as a chronic, often asymptomatic disorder (i.e., thoracic and abdominal aortic aneurisms, TAA and AAA) or as an acute life-threatening condition i.e., acute aortic syndromes (AAS).

2. Topographic Anatomy of the Thoracic Aorta

The thoracic aorta includes the aortic root, the ascending tract, the arch, and the descending aorta (Figure 1A–C) ^[2].

Figure 1. Topographic anatomy and normal histology of the aorta. (A)—Diagram of the aorta with different colors reflecting the different histogenesis of the SMCs of the tunica media: SMCs of the aortic root derive from the secondary heart field (lateral plate mesoderm) (green); SMCs of ascending aorta and the arch derive from the neural crests (ectoderm) (yellow); SMCs of the descending and abdominal aorta derive from the somites of the paraxial mesoderm (purple). SMCs = smooth muscle cells. (B)—Histological anatomy of the descending aorta with tunica intima (I), media (M), and adventitia (A). The mild fibrous intimal thickening is a typical age-related change. The normal lamellar architecture of the tunica media is preserved and showed at higher magnification in the insert, with its elastic laminae (white arrowheads) and the intervening smooth muscle cells (black arrow) (Hematoxylin and eosin, original magnification 10×; insert: 40×). (C)—The aortic root is the segment between the annulus (red dashed line) and the sinotubular junction (black dotted line) and comprises the sinuses of Valsalva with the aortic cusps (outlined with the orange dashed line), the origin of the coronary arteries (red arrows), and the intercuspal triangles (black diamonds).

The aortic root extends from the annulus to the sinotubular junction (STJ), and comprises the sinuses of Valsalva, with the aortic cusps, the coronary origins, and the intercuspal triangles (Figure 1C) ^[3]^[4]. The annulus is a virtual circular line running through the base of the aortic cusps. It lies distal both to the anatomic ventricular-aortic junction (where cardiac myocytes leave the place to smooth muscle cells of the aortic wall) and the hemodynamic junction, identified by the crown-like attachment of the aortic cusps to the sinuses wall. The STJ is a virtual circular line running through the tip of the aortic valve commissures. The wall of the sinuses of Valsalva is thinner as compared to the wall of the aorta (about 2 mm versus 4 mm).

The ascending aorta comprises the tract from the STJ to approximately the level of the fourth thoracic vertebra, where the brachiocephalic artery takes off. The aortic arch lies between the brachiocephalic artery and the isthmus, distal to the left subclavian artery origin, and gives rise to the brachiocephalic, the left common carotid, and the left subclavian arteries. The descending aorta starts after the take-off of the left subclavian artery and has a thoracic and an abdominal segment.

3. Histology and Histogenesis of the Aorta

The aorta’s elastic properties depend on its wall structure, composed of three distinct histologic layers: intima, media, and adventitia (Figure 1B). The media is the largest component and is formed by concentrically organized lamellar units. Each lamellar unit is composed of two layers of elastic laminae and smooth muscle cells (SMCs), collagen fibers, and proteoglycans lining in between (Figure 1B, insert). The number and thickness of the lamellar units of the media increase with age and, in adults, vary according to topographic location ^[5]. During postnatal growth, the increase in medial thickness in the ascending aorta and arch is achieved through an increase in the number of lamellae (up to 60 in adulthood), whereas in the descending aorta through the thickening of the existing lamellar units (up to 28–30). This different behavior reflects the different embryological origins of SMCs at different topographic sites (Figure 1A), which in turn condition the response of SMCs to growth factor stimuli (e.g., TGF-β). The SMCs of the ascending aorta and the arch derive from the neural crests (i.e., from the ectoderm), while those of the descending aorta derive from the somites of the paraxial mesoderm ^[6]^[7]^[8]. Of note, the ratio between the aortic diameter and the medial thickness remains constant in the different segments of the aorta ^[9]. Thanks to the higher number of lamellar units, the TA is more compliant as compared to the AA.

The aorta does not contain a distinct inner or outer elastic lamina. At birth, the intima is thin and consists of the endothelium alone, in close contact with the first elastic lamella. In the adult, the accumulation of extracellular matrix proteins and mesenchymal cells induces an increase in intimal thickness (Figure 1B). The adventitia comprises loose connective tissue, vasa vasorum, and lymphatic vessels. Vasa vasorum normally extends into the outer third of the media.

4. Embryology of the Aorta

4.1. Embryology of the Aortic Root

The aortic root development is strictly connected with the embryology of the cardiac outflow tract (Figure 2). In midweek 5 of embryogenesis, cells from the neural crest migrate in the truncus arteriosus (the cranial portion of the primitive heart tube) and contribute to the formation of a spiral conotruncal septum, which separates the aortic and pulmonary outflow tracts ^[8]. From the wall of each tract, three endocardial swellings give rise to the cusps of the semilunar valves of the aorta and pulmonary artery. Excavation of truncal tissue inferior to the aortic swellings leads to the formation of the sinus of Valsalva.

Figure 2. Embryologic development of the thoracic aorta and its branches. (A)—The scheme highlights the development of the six arches from the aortic sac during the 5th week of development, the 1st and 2nd arches have regressed (dashed line). The truncus arteriosus is partially divided by the conotruncal septum. (B)—Aortic arches at 7 weeks of development. The segments of the dorsal aorta connecting the third and fourth arch arteries disappear, as well as the fifth, part of the right and sixth arches and a portion of the right dorsal aorta. (C)—At 8 weeks, the thoracic aorta and the epiaortic vessels have almost completed their development. Note the patency of the ductus arteriosus, originating from the left sixth aortic arch.

4.2. Embryology of the Ascending Aorta, Aortic Arch, and Descending Aorta

During the third week of gestation, isolated vascular islands merge forming the paired primitive aortae. Each primitive aorta consists of a ventral and a dorsal segment in continuity through the first aortic arch. The two ventral aortae are connected to the aortic sac, an expansion at the cranial end of the truncus arteriosus ^[10]^[11]^[12]^[13]^[14].

The dorsal aortae extend for the entire length of the embryo and, during the 4th week, fuse from the fourth thoracic segment to the fourth lumbar segment forming the midline dorsal aorta. The latter will form the descending aorta.

By the 5th week, aortic arches 2, 3, 4, and 6 develop from the aortic sac connecting to the dorsal aortae. The first two arches regress as the later arches form (Figure 2A).

The common carotid and proximal portions of the internal carotid arteries originate from the third pair of aortic arches. The distal portion of the internal carotid arteries arises from the cranial end of the dorsal aortae (Figure 2B). The development of the fourth pair of arches is asymmetric. On the right side, the fourth arch forms the proximal portion of the right subclavian artery. The distal portion of the right subclavian artery derives from the right dorsal aorta. The aortic sac forms the brachiocephalic trunk and the first portion of the aortic arch. On the left side, the fourth arch becomes the arch of the aorta. The sixth arch contributes to the formation of the main pulmonary artery, its branches, and ductus arteriosus. Here, neural crest cells play a pivotal role in the formation of the aorticopulmonary septum, which fuses with the conotruncal septum separating the aortic and pulmonary channels ^[8]. On the left side, the distal portion of the left arch remains in communication with the dorsal aorta, forming the ductus arteriosus. The ductus arteriosus closes at birth and is later transformed into the ligamentum arteriosum, which attaches the pulmonary trunk to the aorta (Figure 2C).

References

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Kaukis, R.; Kaoukis, R.; Dieter, R.S.; IOkundaye, I.; Dauzvardis, M.; Frysztak, R.J.; Ibrahim, W.; Pyle, M.J. Embryology and Anatomy of the Aorta in: Diseases of Aorta, 3rd ed.; Springer Nature: Berlin/Heidelberg, Germany, 2019.
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