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Topic Review
Trabectedin and Lurbinectedin in the Tumour Microenvironment
Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural analogues that differ on the tetrahydroisoquinoline moiety of the C subunit in TRB, which is replaced by a tetrahydro-β-carboline in LUR.
  • 168
  • 22 Jan 2024
Topic Review
TPPP-like Proteins in Myzozoa
TPPP-like proteins contain one or more p25alpha domains. They obtained their name after tubulin polymerization promoting protein (TPPP1), the first identified member of this protein family. Originally, it was named p25alpha protein, which became the eponym of the domain. Myzozoans are a monophyletic clade, and a sister clade to the Ciliata, within Alveolata.
  • 370
  • 16 Jun 2023
Topic Review
TPP1 Gene
Tripeptidyl peptidase 1: The TPP1 gene provides instructions for making an enzyme called tripeptidyl peptidase 1.
  • 428
  • 25 Dec 2020
Topic Review
TPO Gene
Thyroid peroxidase: The TPO gene provides instructions for making an enzyme called thyroid peroxidase.
  • 431
  • 25 Dec 2020
Topic Review
TPMT Gene
Thiopurine S-methyltransferase: The TPMT gene provides instructions for making an enzyme called thiopurine S-methyltransferase (TPMT).
  • 482
  • 25 Dec 2020
Topic Review
TPM3 Gene
Tropomyosin 3: The TPM3 gene provides instructions for making a protein called slow muscle alpha (α)-tropomyosin, which is part of the tropomyosin protein family. 
  • 481
  • 25 Dec 2020
Topic Review
TPM2 Gene
Tropomyosin 2: The TPM2 gene provides instructions for making a protein called beta (β)-tropomyosin, which is part of the tropomyosin protein family. 
  • 441
  • 25 Dec 2020
Topic Review
TPI1 Gene
Triosephosphate isomerase 1: The TPI1 gene provides instructions for making an enzyme called triosephosphate isomerase 1.
  • 518
  • 25 Dec 2020
Topic Review
TPC1 in plants
TPC1 in plants is localized in the vacuolar membrane. Its activity is strictly regulated by several factors emphasizing its complex structure and function. The physiological role of TPC1 is under debate. The TPC1 hyperactive version fou2 (carring D454N mutation) is characterized by an overproduction of jasmonate acid (JA), however the tpc1-2 knockout mutant has no pronounced phenotype. The intriguing concept of Ca2+-induced Ca2+ release was assigned to Vicia faba TPC1 in 1994 by Ward and Schroeder, however it has still not been confirmed for the model plant Arabidopsis thaliana.
  • 1.0K
  • 27 Oct 2020
Topic Review
TP63 Gene
Tumor protein p63: The TP63 gene provides instructions for making a protein called tumor protein p63 (also known simply as p63). 
  • 544
  • 25 Dec 2020
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