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Topic Review
Alpheus (Genus)
Alpheus is a genus of snapping shrimp of the family Alpheidae. This genus contains in excess of 250 species, making this the most species-rich genus of shrimp. Like other snapping shrimp, the claws of Alpheus are asymmetrical, with one of the claws enlarged for making a popping noise. Some species in the genus enter into symbiotic relationships with gobiid fishes.It's also the noisiest of all sea creatures and can immobilize small fish with its high pitched frequency.
  • 387
  • 09 Oct 2022
Topic Review
Alpheus (Shrimp)
Alpheus is a genus of snapping shrimp of the family Alpheidae. This genus contains in excess of 291 species, making this the most species-rich genus of shrimp. Like other snapping shrimp, the claws of Alpheus are asymmetrical, with one of the claws enlarged for making a popping noise. Some species in the genus enter into symbiotic relationships with gobiid fishes, and others associate with sea anemones. It's also the noisiest of all sea creatures and can immobilize small fish with its high pitched frequency.
  • 407
  • 30 Nov 2022
Topic Review
Alport Syndrome
Alport syndrome is a genetic condition characterized by kidney disease, hearing loss, and eye abnormalities.
  • 532
  • 24 Dec 2020
Topic Review
ALS-Specific GWAS Challenges
Amyotrophic Lateral Sclerosis (ALS) is the most common late-onset motor neuron disorder, but our current knowledge of the molecular mechanisms and pathways underlying this disease remains elusive. Genome-Wide Association Studies (GWAS) aim to identify Single Nucleotide Polymorphisms (SNPs) and other types of genetic variation that are more frequent in patients than in people without the disease, using a variety of statistical tests. Despite the rapid recent technological advances and great efforts in the GWAS field that have led to the genomic profiling of large ALS cohorts, the identified associations have been able to explain only a very small fraction of the ALS heritability and aetiology. Here, we outline ALS-Specific GWAS Challenges, explaining the limitations of traditional GWAS analyses, considering known features of the ALS genetic architecture and hypotheses about ALS pathology (e.g., multilocus interactions, rare variations with low effect size). Future advances in the genomic and machine learning fields may bring about a better understanding of ALS genetic architecture and enable improved personalized approaches to this and other devastating and complex diseases.
  • 716
  • 01 Dec 2021
Topic Review
ALS2 Gene
ALS2, alsin Rho guanine nucleotide exchange factor. The ALS2 gene provides instructions for making a protein called alsin.
  • 390
  • 24 Dec 2020
Topic Review
ALS2-Related Motor Neuron Diseases
Mutations of the ALS2 gene, which encodes for the protein Alsin, are linked to three recessive motor neuron diseases characterized by early onset. Alsin is an intriguing protein characterized by several structured domains with distinct functions. 
  • 461
  • 20 Jan 2022
Topic Review
Alsophila Dealbata
Alsophila dealbata, synonym Cyathea dealbata, commonly known as the silver fern or silver tree-fern, or as ponga /ˈpɒŋə/ or punga /ˈpʌŋə/ (from Māori kaponga or ponga), is a species of medium-sized tree fern, endemic to New Zealand. The fern is usually recognisable by the silver-white colour of the under-surface of mature fronds. It is a symbol commonly associated with the country both overseas and by New Zealanders themselves.
  • 868
  • 02 Nov 2022
Topic Review
ALSP
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a neurological condition characterized by changes to certain areas of the brain. A hallmark of ALSP is leukoencephalopathy, which is the alteration of a type of brain tissue called white matter. White matter consists of nerve fibers (axons) covered by a substance called myelin that insulates and protects them. The axons extend from nerve cells (neurons) and transmit nerve impulses throughout the body. Areas of damage to this brain tissue (white matter lesions) can be seen with magnetic resonance imaging (MRI). Another feature of ALSP is swellings called spheroids in the axons of the brain, which are a sign of axon damage. Also common in ALSP are abnormally pigmented glial cells. Glial cells are specialized brain cells that protect and maintain neurons. Damage to myelin and neurons is thought to contribute to many of the neurological signs and symptoms in people with ALSP.
  • 615
  • 04 Jan 2021
Topic Review
Alt a 1 Protein Family in Phylogenetic-Related Alternaria
Alternaria is a genus of worldwide fungi found in different habitats such as soil, the atmosphere, plants or indoor environments. Alternaria species are saprobic—largely involved in the decomposition of organic material—but they can also act as animal pathogens, causing disease in humans and animals, developing infections, toxicosis and allergic diseases. A. alternata is considered one of the most important sources of fungal allergens worldwide and it is associated with severe asthma and respiratory status. In fact,  Alt a 1, the main allergen of A. alternata, is an important marker for assessing the risk factor and severity of allergic respiratory disease. Another role of Alt a 1, from a evolutionary point of view, would be to define a family of proteins that would allow establishing taxonomic relationships between different fungal divisions. Finally, Alt a 1 has been shown to be a very useful marker for the identification of pathogenic molds contaminating plants and fruits.
  • 423
  • 28 Apr 2022
Topic Review
Altered Glucose Dependency in Drug-Resistant Cancer Cells
A chemotherapeutic approach is crucial in malignancy management, which is often challenging due to the development of chemoresistance. Over time, chemo-resistant cancer cells rapidly repopulate and metastasize, increasing the recurrence rate in cancer patients. Targeting these destined cancer cells is more troublesome for clinicians, as they share biology and molecular cross-talks with normal cells. 
  • 136
  • 22 Sep 2023
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