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Biography
Katherine Freese
Katherine Freese is a theoretical astrophysicist and George Eugene Uhlenbeck Collegiate Professor of Physics at the University of Michigan in Ann Arbor. Starting in September 2014, she assumed the position of Director of Nordita, the Nordic Institute for Theoretical Physics, in Stockholm, and holds a position as Visiting Professor of Physics at Stockholm University. She is known for her work in
  • 1.3K
  • 06 Dec 2022
Topic Review
Single-Chromosome Sequencing
Sequencing of DNA from single isolated chromosomes (ChromSeq) is an elegant approach to determine the chromosome content and assign genome assemblies to chromosomes, thus bridging the gap between cytogenetics and genomics. 
  • 1.3K
  • 17 Mar 2021
Topic Review
Vector Transmission of Plant Viruses
Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector.
  • 1.3K
  • 02 Feb 2021
Topic Review
Intestinal Mucus
Overlying gastrointestinal epithelial cells is the transparent mucus layer that separates the lumen from the host. The dynamic mucus layer serves to lubricate the mucosal surface, to protect under-lying epithelial cells, and as a transport medium between luminal contents and epithelial cells. Furthermore, it provides a habitat for commensal bacteria and signals to the underlying immune system. Mucins are highly glycosylated proteins, and their glycocode is tissue-specific and closely linked to the resident microbiota. 
  • 1.3K
  • 19 Feb 2021
Topic Review
Reproductive Technologies Used in Male Neo-Tropical Hystricomorphic Rodents
To improve efficient reproduction, reproductive technologies are commonly used in domesticated animals; therefore, it is wise to explore the feasibility of their application on Neo-tropical rodents, an alternative meat source with the potential to aid in conservation and wildlife farming. However, there must first be a proper understanding of their reproductive anatomy, before reproductive technologies can be utilized. The penis of the agouti and the paca (Cuniculus paca), for example, were found to be covered in penile spines with two keratinized spines and two lateral penile cartilages on either side of the glans penis, unlike the capybara (Hydrochoerus hydrochaeris). Different methods can be used to collect semen from these animals and, based on the performed review, it has been shown that coconut water powder (ACP-123) is a good diluent for both the agouti and the paca, giving higher spermatozoa parameters compared with those obtained via electro ejaculation. 
  • 1.3K
  • 17 Jan 2022
Topic Review
Chromosomal instability in Fanconi anemia
Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway. This pathway regulates the repair of DNA interstrand crosslinks (ICLs) through homologous recombination. In FA proper repair of ICLs is impaired and accumulation of toxic DNA double strand breaks occurs. To repair this type of DNA damage, FA cells activate alternative error-prone DNA repair pathways, which may lead to the formation of gross structural chromosome aberrations of which radial figures are the hallmark of FA, and their segregation during cell division are the origin of subsequent aberrations such as translocations, dicentrics and acentric fragments. The deficiency in DNA repair has pleiotropic consequences in the phenotype of patients with FA, including developmental alterations, bone marrow failure and an extreme risk to develop cancer.
  • 1.3K
  • 15 Jan 2021
Topic Review
Satellite
A satellite is a subviral agent that depends on the coinfection of a host cell with a helper virus for its replication. Satellites can be divided into two major classes: satellite viruses and satellite nucleic acids. Satellite viruses, which are most commonly associated with plants, are also found in mammals, arthropods, and bacteria. They encode structural proteins to enclose their genetic material, which are therefore distinct from the structural proteins of their helper viruses. Satellite nucleic acids, in contrast, do not encode their own structural proteins, but instead are encapsulated by proteins encoded by their helper viruses. The genomes of satellites range upward from 359 nucleotides in length for satellite tobacco ringspot virus RNA (STobRV). Most viruses have the capability to use host enzymes or their own replication machinery to independently replicate their own viral RNA. Satellites, in contrast, are completely dependent on a helper virus for replication. The symbiotic relationship between a satellite and a helper virus to catalyze the replication of a satellite genome is also dependent on the host to provide components like replicases to carry out replication. A satellite virus of mamavirus that inhibits the replication of its host has been termed a virophage. However, the usage of this term remains controversial due to the lack of fundamental differences between virophages and classical satellite viruses.
  • 1.3K
  • 20 Oct 2022
Topic Review
Arabinoxylans
The health benefits of fibre consumption are sound, but a more compressive understanding of the individual effects of different fibres is still needed. Arabinoxylan is a complex fibre that provides a wide range of health benefits strongly regulated by its chemical structure. Arabinoxylans can be found in various grains, such as wheat, barley, or corn.
  • 1.3K
  • 13 Apr 2022
Topic Review
Chordae tendineae in Animal Models
Myxomatous mitral valve disease (MMVD) is the most common canine heart disease in which, among other things, chordae tendineae rupture occurs. The Chordae tendineae (CT) are part of the atrioventricular apparatus. They are mainly responsible for the mechanical functions of heart valves.  In our study we performed biomechanical and histopathological examination of CT in order to better understand the functioning of the valvular apparatus. It is clinically relevant  to begin further studies about biomarkers suggesting an episode of CT rupture, as such an episode leads to acute pulmonary oedema and worsens the clinical status of the patient.
  • 1.3K
  • 24 Jun 2021
Topic Review
Pratylenchus
Root-lesion nematodes of the genus Pratylenchus are migratory endoparasites belonging to the family Pratylenchidae (Nematoda, Tylenchina), with around 100 species recognized today.
  • 1.3K
  • 21 Jan 2021
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