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Topic Review
History of Global Germplasm Conservation System
Conservation of plant genetic resources has become an urgent activity as these resources are quickly disappearing, both in the wild as well as on farmers’ fields. In particular crop wild relatives and farmers varieties, also known as landraces, which are of particular interest for plant breeding, are under severe threat of extinction. As crop genetic resources are quite dispersed, regionally and even globally, germplasm conservation efforts require regional and, in many instances, global coordination. Thus, since the 1950s FAO has been actively involved, together with institutions such as IBPGR in the establishment and operation of a global ex situ conservation system, and where possible, effectively linked with in situ and on-farm management activities. This global system has somewhat spontaneously evolved and thus, the current system reflects still strongly the history of its ‘evolution’. To improve the present global system and make it more efficient, it is necessary to analyse and understand the historical and political aspects of its development and ‘evolution’ and this is the focus of the present paper. 
  • 1.4K
  • 19 Oct 2021
Topic Review
Cannabis Sativa Revisited
Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. In detail, the entry shows the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression will be presented.
  • 1.4K
  • 04 Jul 2022
Topic Review
Marine Organism-Derived Polydeoxyribonucleotide
Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. 
  • 1.4K
  • 26 May 2021
Topic Review
Tumor Temperature
The temperature of a solid tumor is often dissimilar to baseline body temperature and, compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of a tumor is dependent on metabolic activity and vascularization and can change due to tumor progression, treatment, or cancer type.
  • 1.4K
  • 13 Sep 2022
Topic Review
Congenital Microcoria
Iris integrity is required to regulate both the amount of light reaching the retina and intraocular pressure (IOP), with elevated IOP being a major risk factor for glaucoma. Congenital microcoria (MCOR) is an extremely rare, autosomal dominant disease affecting iris development and hindering both of these functions. 
  • 1.4K
  • 22 Sep 2021
Topic Review
L-Citrulline
L-citrulline (CIT) is an organic compound and a non-essential amino acid, and the body can synthesize it endogenously. Diet is a poor source of CIT and endogenous synthesis the its main source in the body. Watermelon is the principal source of that amino acid in the diet; the name citrulline comes from Citrullus lanatus (Thunb.), the scientific name for watermelon. CIT concentration in watermelon depends on the type of cultivir and usually ranges between 0.7 and 3.6 g/kg of fresh weight. CIT is present in both the flesh and in the ring.
  • 1.4K
  • 06 May 2021
Topic Review
Compounds Exhibiting Antioxidant and Anti-Browning Properties
The browning process is a natural phenomenon occurring in fruit and vegetable, which has become a challenge in the food industry sector. The undesired condition caused by browning processes has a significant impact on food quality as it causes deterioration in nutritional and sensory properties, as well as safety. Enzymatic browning is an oxidation reaction. This reaction can be prevented by the removal of oxygen from the cut surface of fruit and vegetables. Nonetheless, the browning can be recovered when oxygen is re-established. Therefore, the utilization of antioxidant and browning inhibitors to inactivate the enzymes responsible for browning is widely employed in the food industry, especially the fresh-cut industry. Seeking the natural compounds as food preservatives derived from natural extracts is highly recommended. 
  • 1.4K
  • 22 Mar 2022
Topic Review
Eye Diseases Associated with Oral Pathogens
Even before the advancement of sophisticated molecular biology techniques, eye diseases were regarded as manifestations of infections in the mouth. A few of the ancient studies interrelated the resolution of the given disease upon elimination of oral sepsis by extraction of the infected teeth. In this context, bacteria and or their toxic metabolites and reflex nervous irritation were considered to be the crucial factors. In successive years, the concept of “oral foci of infection” lost its attention. Nonetheless, there are many studies successively acknowledged periodontitis as a risk factor in the pathogenesis of assorted inflammatory eye diseases including scleritis, iritis, glaucoma, diabetic retinopathy (DR), uveitis, retinitis pigmentosa (RP), and Sjogren syndrome (SS).
  • 1.4K
  • 27 Jun 2022
Topic Review
Spawn
Spawn is the eggs and sperm released or deposited into water by aquatic animals. As a verb, to spawn refers to the process of releasing the eggs and sperm, and the act of both sexes is called spawning. Most aquatic animals, except for aquatic mammals and reptiles, reproduce through the process of spawning. Spawn consists of the reproductive cells (gametes) of many aquatic animals, some of which will become fertilized and produce offspring. The process of spawning typically involves females releasing ova (unfertilized eggs) into the water, often in large quantities, while males simultaneously or sequentially release spermatozoa (milt) to fertilize the eggs. Most fish reproduce by spawning, as do most other aquatic animals, including crustaceans such as crabs and shrimps, molluscs such as oysters and squid, echinoderms such as sea urchins and sea cucumbers, amphibians such as frogs and newts, aquatic insects such as mayflies and mosquitoes and corals, which are actually small aquatic animals—not plants. Fungi, such as mushrooms, are also said to "spawn" a white, fibrous matter that forms the matrix from which they grow. There are many variations in the way spawning occurs, depending on sexual differences in anatomy, how the sexes relate to each other, where and how the spawn is released and whether or how the spawn is subsequently guarded.
  • 1.4K
  • 08 Nov 2022
Topic Review
Detecting Analytes in Urine for Urinalysis
Human urine samples contain several components that can indicate the health condition of a patient, and therefore aid in the diagnosis of common clinical conditions such as diabetes mellitus (DM), urinary tract infections (UTIs), renal stone disease, kidney disorders, liver problems, obesity, other metabolic disorders, or fetal hypothyroidism. Urine samples also provide evidence of underlying health problems in pre-symptomatic and asymptomatic individuals, which can facilitate early intervention and therapy. These benefits play an important role in encouraging individual access to continuous and regular health monitoring.
  • 1.4K
  • 06 Dec 2022
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