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Topic Review
Biopesticide Global Market, Categories and Regulation
Biopesticides are formulations derived from naturally occurring compounds that manage pests through non-toxic and environmentally favorable means. Being living organisms (natural enemies) or products, biopesticides represent less of a risk to the environment and to human health. Biopesticides, classified into three broad classes, are increasingly used in pest control, and include semiochemicals, plant-incorporated protectants (PIPs), and compounds derived from plants and microorganisms.
  • 1.1K
  • 07 Mar 2023
Topic Review
GLP-1R Signaling
Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and blood glucose regulation has been extensively studied. Numerous drugs targeting GLP-1R have entered clinical treatment. Novel functional molecules with reduced side effects and enhanced therapeutic efficacy are still in high demand. 
  • 1.1K
  • 06 Feb 2023
Topic Review
Dairy Products through the Addition of Microalgae
Microalgae are prokaryotic or eukaryotic photosynthetic microorganisms which have the ability to grow fast and to live under conditions not favorable to other species. They are attracting increasing attention, as their incorporation in foods and beverages can be a promising strategy to develop sustainable foods with improved nutritional profiles and a strong positive impacts on health. Despite the increasing market demand in plant-based foods, the popularity of fermented dairy foods has increased in the recent years since they are a source of microorganisms with health-promoting effects. In this context, the incorporation of microalgae in cheeses, fermented milks and other dairy products represents an interesting approach towards the development of innovative and added-value hybrid products based on animal proteins and enriched with vegetable origin ingredients recognized as extremely valuable sources of bioactive compounds.
  • 1.1K
  • 21 Mar 2022
Topic Review
Mechanisms of Ferroptosis
Ferroptosis, mainly mediated by iron-dependent lipid peroxidation, is closely linked to multiple physiological and pathological processes in humans and animals, including cancer, arteriosclerosis, ischemia-reperfusion injury, neurodegenerative diseases, and acute renal failure.
  • 1.1K
  • 10 Dec 2021
Topic Review
Natural Biomolecules in Sperm Production
Poor semen quality and abnormal sperm structure or function by and large constitute a predominant presentation of male infertility and are among the major reasons why couples seek the services of assisted reproduction. Natural biomolecules, such as polyphenols or flavonoids have garnered substantial attention from the scientific community as well as public media. In the meantime, it has been suggested that administration of natural biomolecules has been shown to have a positive impact male infertility. A number of in vivo as well as in vitro studies have reported that active components isolated from natural resources could enhance blood circulation in the male reproductive system and support the synthesis and secretion of androgens. Animal and human reports also suggest that natural biomolecules may play important roles in the enhancement of semen quality, including sperm concentration, motility, vitality, and structural integrity. 
  • 1.1K
  • 23 Sep 2021
Topic Review
Gangliosides in Vascular
Vascular diseases, such as myocardial infarction and cerebral infarction, are most commonly caused by atherosclerosis, one of the leading causes of death worldwide. Several types of cells, such as vascular (endothelial cell), vascular-associated (smooth muscle cell and fibroblast) and inflammatory cells, are involved in plaque formation, plaque rupture and thrombus formation, which result in atherosclerosis. Gangliosides, a group of glycosphingolipids, are expressed on the surface of vascular, vascular-associated and inflammatory cells, where they play functional roles. Here we introduce gangliosides expressed on those cells and their relevance to vascular diseases.
  • 1.1K
  • 23 Oct 2020
Topic Review
GPCR, ER Stress, and EMT
Endoplasmic reticular stress (ERS) is a dynamics adaptive mechanism that is triggered upon perturbations in ER homeostasis. Hence unfolded protein response (UPR) is activated by ERS as a distress signal. UPR is involved in cancer progression by aiding cells to adapt harsh environments and evading cell death. We have made a significant discovery in the area of ERS and cell death in colonic epithelial cells where have previously unraveled the relationship between ERS and anti- apoptotic protein Survivin in colon cancer cells. We established a time point for an aggressive ERS environment with the help of ERS dynamics thereby creating a perfect environment for testing drugs. However, the role of ERS in cancer is still perplexing. G-protein coupled receptors (GCPR) are another large family of cell surface receptors that respond to a variety of external signals. GPCRs are said to have an active association with ERS in order to trigger some key processes like epithelial mesenchymal transition (EMT) which is a prime step in metastasis. However, there are some essential candidates that play a role in hindering cancer progression through numerous pathways. We therefore wish to provide the readers with an exhaustive views and insights of ER stress biology.
  • 1.1K
  • 12 Oct 2020
Topic Review
Toxoplasma gondii-Induced and Associated Diseases
Toxoplasma gondii (T. gondii) is a prevalent protozoan parasite of medical and veterinary significance. It is the etiologic agent of toxoplasmosis, a neglected disease in which incidence and symptoms differ between patients and regions. In immunocompetent patients, toxoplasmosis manifests as acute and chronic forms. Acute toxoplasmosis presents as mild or asymptomatic disease that evolves, under the host immune response, into a persistent chronic disease in healthy individuals. Chronic toxoplasmosis establishes as latent tissue cysts in the brain and skeletal muscles. In immunocompromised patients, chronic toxoplasmosis may reactivate, leading to a potentially life-threatening condition. 
  • 1.1K
  • 05 Nov 2021
Topic Review
Spironolactone and XPB
Spironolactone (SP) is commonly used for the treatment of heart failure, hypertension, and complications of cirrhosis by antagonizing the mineralocorticoid receptor. However, SP also antagonizes the androgen receptor, and thus SP has also been shown to be effective in the treatment of acne, hair loss, and hirsutism in women. Interestingly, recent drug repurposing screens have identified new and diverse functions for SP as a simulator of tumor immunosurveillance and as an inhibitor of DNA repair and viral infection. These novel pharmacological effects of SP have all been linked to the ability of SP to induce the rapid proteolytic degradation of the xeroderma pigmentosum group B (XPB) protein. XPB is a critical enzymatic component of the multi-subunit complex known as transcription factor II-H (TFIIH), which plays essential roles in both DNA repair and the initiation of transcription. Given the critical functions for XPB and TFIIH in these processes, the loss of XPB by SP could lead to mutagenesis. However, the ability of SP to promote cancer stem cell death and facilitate immune recognition may counteract the negative consequences of SP to mitigate carcinogenic risk. Thus, SP appears to have new and interesting pharmacological effects that may extend its potential uses.
  • 1.1K
  • 21 Jun 2021
Topic Review
Yeast Hybrids in Brewing
Microbiology has long been a keystone in fermentation, and innovative yeast molecular biotechnology continues to represent a fruitful frontier in brewing science. Consequently, modern understanding of brewer’s yeast has undergone significant refinement over the last few decades.
  • 1.1K
  • 22 Feb 2022
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