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Topic Review
Nystatin-Added Tissue Conditioners for DIS
Denture-induced stomatitis (DIS) represents a pathological condition caused by ill-fitting dentures trauma, manifested as inflammation of the palatal tissue beneath the denture. The fungal infec-tions are the principal contributory factors to DIS. Although the aetiology of DIS is multifactorial, the Candida albicans fungal infection remains the main cause.
  • 399
  • 25 Feb 2021
Topic Review
Nrf2 and NLRP3 in the Field of Dentistry
The functional implications of the nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2 (Nrf2), with special attention to the NACHT (nucleotide-binding oligomerization), LRR (leucine-rich repeat), and PYD (pyrin domain) domains-containing protein 3 (NLRP3) inflammasome in the field of dentistry were summarized. NLRP3 plays a crucial role in the progression of inflammatory and adaptive immune responses throughout the body. It is already known that this inflammasome is a key regulator of several systemic diseases. The initiation and activation of NLRP3 starts with the oral microbiome and its association with the pathogenesis and progression of several oral diseases, including periodontitis, periapical periodontitis, and oral squamous cell carcinoma (OSCC). Understanding the cellular and molecular biology of the NLRP3 inflammasome and its relationship to Nrf2 is necessary for the rationale when suggesting it as a potential therapeutic target for treatment and prevention of oral inflammatory and immunological disorders.
  • 483
  • 21 Feb 2022
Topic Review
Novel Antibacterial Approaches for Eradicating Dental Biofilm
Periodontitis is a multifactorial chronic inflammatory disease that affects tooth-supporting soft/hard tissues of the dentition. The dental plaque biofilm is considered as a primary etiological factor in susceptible patients; however, other factors contribute to progression, such as diabetes and smoking. Current management utilizes mechanical biofilm removal as the gold standard of treatment. Antibacterial agents might be indicated in certain conditions as an adjunct to this mechanical approach. Studies suggest efficacy in the use of adjunctive antimicrobials in patients with grade C periodontitis of young age or where the associated risk factors are inconsistent with the amount of bone loss present. Meanwhile, alternative approaches such as photodynamic therapy and probiotics showed limited supportive evidence, and more studies are warranted to validate their efficiency.
  • 429
  • 20 Jan 2022
Topic Review
Non-Plaque Induced Diffuse Gingival Overgrowth
Non-plaque-induced gingival overgrowth (NPIGO) is part of a heterogeneous class of rare gingival modifications, due to a wide range of systemic conditions.
  • 588
  • 21 Apr 2022
Topic Review
Non-Coding RNA Transcriptome
Non-coding RNAs (ncRNAs) represent a research hotspot by playing a key role in epigenetic and transcriptional regulation of diverse biological functions. Due to their involvement in DNA translational control, their regulation of mRNA and protein expression levels and their ability to reprogram cellular signaling pathways in oral inflammatory diseases, ncRNA could be used to diagnose and predict disease and to improve patient-tailored treatments, as integral part of precision medicine for oral inflammatory diseases. 
  • 377
  • 09 Aug 2022
Topic Review
No-pain Removal of HPV Lesions in Oral Cavity
Human Papilloma Virus (HPV) infection: verruca vulgaris (VV), squamous cell papilloma (SP), condyloma acuminatum (CA), and multifocal epithelial hyperplasia (MFEH), all of them are a benign hyperplastic exophytic proliferation of the oral epithelium, caused by different HPV genotypes. Subtypes 6 and 11, with a low-oncogenic risk, are the most commonly found and cause CA in both the oral cavity and in the anogenital region. Labial mucosa, soft palate and lingual frenum are the most common locations of CA and koilocytes can be observed in histopathologic sections. All HPV-related oral lesions present clinical similarities, and therefore, a biopsy is necessary for a precise diagnosis.
  • 466
  • 19 Oct 2021
Topic Review
Nickel-Titanium Rotary Instruments in Endodontics
Since the introduction of Nickel-Titanium alloy as the material of choice for the manufacturing of endodontic rotary instruments, the success rate of the root canal therapies has been significantly increased. This success mainly arises from the properties of the Nickel-Titanium alloy: the biocompatibility, the superelasticity and the shape memory effect. Those characteristics have led to a reduction in time of endodontic treatments, a simplification of instrumentation procedures and an increase of predictability and effectiveness of endodontic treatments. Nevertheless, the intracanal separation of Nickel-Titanium rotary instruments is still a major concern of endodontists, with a consequent possible reduction in the outcome rate. As thoroughly demonstrated, the two main causes of intracanal separation of endodontic instruments are the cyclic fatigue and the torsional loads. As results, in order to reduce the percentage of intracanal separation researches and manufacturers have been focused on the parameters that directly or indirectly influence mechanical properties of endodontic rotary instruments. This entry describes the current state of the art regarding the Nickel-Titanium alloy in endodontics, the mechanical behavior of endodontic rotary instruments and the relative stresses acting on them during intracanal instrumentation, highlighting the limitation of the current literature.
  • 1.3K
  • 24 Jan 2022
Topic Review
Nerve Injury and Photobiomodulation
The available therapeutic options for restoring function and sensitivity in long-term nervous injuries pose challenges. Microsurgery interventions for direct nerve repair often lead to serious complications and limited success. Non-surgical methods, although somewhat effective, have limited benefits. These methods involve drug administration, such as with analgesics or corticosteroids. Photobiomodulation therapy (PBMT) has emerged as a promising approach based on clinical and laboratory studies. PBMT stimulates the migration and proliferation of neuronal fiber cellular aggregates. Experimental studies on animal models with peripheral nerve compression injuries have shown that PBMT can enhance the functionality of damaged nerves, preserving their activity and preventing scar tissue formation. The mechanism of action depends on the wavelength, which can positively or negatively affect photo acceptor resonances, influencing their conformation and activities. These findings suggest that photobiomodulation may accelerate and improve nerve regeneration.
  • 241
  • 01 Sep 2023
Topic Review
Nanoparticles in Dentistry
In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. 
  • 536
  • 16 Aug 2021
Topic Review
Nanomaterials in Dentistry
       Nanomaterials are commonly considered as those materials in which the shape and molecular composition at a nanometer scale can be controlled. Subsequently, they present extraordinary properties that are being useful for the development of new and improved applications in many fields, including medicine. In dentistry, several research efforts are being conducted, especially during the last decade, for the improvement of the properties of materials used in dentistry.
  • 1.3K
  • 29 Oct 2020
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