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Topic Review
Sjögren’s Syndrome-Related Organs Fibrosis
Sjögren’s syndrome (SS) is a systemic chronic autoimmune disorder characterized by lymphoplasmacytic infiltration of salivary glands (SGs) and lacrimal glands, causing glandular damage. The disease shows a combination of dryness symptoms found in the oral cavity, pharynx, larynx, and vagina, representing a systemic disease. The data in the literature relating to organ fibrosis correlated with SS are presented. The phenomenon has been extensively studied in SGs, where the molecular mechanisms that could trigger fibrosis are known and have been correlated with epithelial to mesenchymal transition (EMT). Cases of secondary fibrosis have also been observed, which could be correlated with the state of chronic inflammation that characterizes SS.
  • 442
  • 20 Jul 2022
Topic Review
Guided Endodontic Surgery
Endodontic surgery has evolved over the past. The use of state-of-the-art guided endodontic surgical procedures produces a predictable outcome in the healing of lesions of endodontic origin. Surgical-guided endodontics is a relatively new area of study that is still maturing. It has many applications such as root canal access and localization, microsurgical endodontics, endodontic retreatment, and glass fiber post removal. Additionally, it does not matter how experienced the operator is; the procedure can be completed for the patient in less time and provides greater accuracy and safety than conventional endodontics.
  • 441
  • 14 Apr 2023
Topic Review
Chronic Kidney Disease, Periodontitis, Red Complex Bacteria, TNF-α
Periodontitis, referred to as gum disease, is a serious bacterial infection that damages the surrounding structures of the teeth, including the supporting bones, lastly without prompt treatment resulting in tooth loss.
  • 437
  • 23 Mar 2022
Topic Review
Marine Biopolymer Alginate in Endodontics
Alginate is a natural marine biopolymer that has been widely used in biomedical applications, but research on its use as an endodontic material is still sparse in the literature. Alginate or salt of alginic acid is one of the most abundant biopolymeric hydrocolloids derived primarily from seaweeds. In dentistry, hydrocolloid alginate has been commonly employed as a dental impression material to make gypsum casts for various treatment purposes, including provisional crowns and bridges, orthodontic study models, mouth guards, bleaching trays, and removable dental prostheses.
  • 436
  • 31 Aug 2022
Topic Review
Effectiveness of Lasers in Treating Oral Mucocele
Oral mucoceles are non-neoplastic cystic lesions of major and minor salivary glands that commonly occur in the oral cavity. All studies indicated successful clinical results on mucocele excision with better intra- and post-operative indicators. The general characteristics and outcomes were summarized, and the quality of the studies was assessed using CARE guidelines. The reduction or absence of pain and bleeding, hemostasis, reduced operating time, minimal analgesic consumption, and an antibacterial effect were among the advantages of laser irradiation in the included studies. The laser has proven itself to play an effective role in the treatment of oral mucocele in paediatric patients. 
  • 433
  • 19 Apr 2022
Topic Review
SARS-CoV-2 and Oral Health
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Wuhan, China, was first reported to the China Ministry of Health and the World Health Organization (WHO), on 31 December 2019. These initial cases were linked to an animal wet market. The SARS-CoV-2 and its virulent variants cause coronavirus disease 2019 (COVID-19), which is highly contagious and spreads rapidly. The WHO declared it a global emergency on 30 January 2020, and a global pandemic on 11 March 2020. The SARS-CoV-2 genome was identified to be 70–80% identical to the severe acute respiratory syndrome coronavirus (SARS-CoV) and several bat coronaviruses. The similarity between these coronaviruses suggests that the bat may be the natural host and potential reservoir for SARS-CoV-2, which may have been inadvertently transmitted to humans. SARS-CoV-2 transmits readily via droplet transmission; other modes of transmission may include aerosol and oral-fecal routes. It can also be transmitted via contact with infected surfaces and oral fluids. This puts dentists and healthcare professionals at risk of COVID-19 infections, and highlights dental and medical offices as a main risk setting for cross infection of patients and healthcare professionals. Mask, face shields, handwashing, and personal protective equipment (PPE) are currently used in dental and medical facilities for COVID-19 prevention consistent with CDC guidelines.
  • 429
  • 01 Jul 2022
Topic Review
MMPs and MMP-8 in Periodontal Diseases
Matrix metalloproteinases (MMPs) are a large family of Ca2+ and Zn2+ dependent proteolytic enzymes, able to cleave the various components of the extracellular matrix (ECM), as well as a range of other regulatory molecules. It has proven the important role of both MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), in oral health, the initial development of the tooth, and during enamel maturation.
  • 428
  • 07 Jul 2023
Topic Review
Multiple Sclerosis in Dental Considerations
Multiple sclerosis is a chronic demyelinating disorder that primarily affects the myeline covering of neurons of the central nervous system. 
  • 429
  • 12 Jul 2023
Topic Review
Effect of Oral Infections on Systemic Health
Immunological mechanisms are known to affect the oral cavity with characteristic pathologic alterations. Infections in general have been suggested to trigger autoimmune diseases such as rheumatic diseases and diabetes and their oral microorganisms such as P. gingivalis may play a role. In The Stockholm Study, the prevalence of autoimmune diseases was investigated and 50 such patients were detected in the database.
  • 426
  • 22 Apr 2022
Topic Review
Prevalence and Features of Oral Lesions in COVID-19
Regardless of rapidly emerging findings on oral lesions described in adult SARS-CoV-2-positive subjects, the evidence level remains quite low and rather contrasting. It is well known that multiple viral pathogens, first of all, Herpes and human Papilloma viruses, are directly responsible for the genesis of benign, potentially malignant and malignant lesions of the oral mucosa, underlining the necessity to examine the potential causative role of SARS-CoV-2 in oral lesions. 
  • 425
  • 27 Jun 2022
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