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Topic Review
Wood Antimicrobial Behavior Test Method
Some wood species have antimicrobial properties and a variety of methods are used to investigate them. For testing the effect of antimicrobial compounds, direct and indirect methods are used. Meanwhile, the survival of microbes is also tested on surfaces (or material in contact with microbes) to validate the safety of surfaces.
  • 882
  • 29 Oct 2020
Topic Review
Wolfram Syndrome Type 1&Type 2
Wolfram syndrome is a rare neurodegenerative disorder that is typically characterized by diabetes mellitus and optic atrophy. 
  • 327
  • 12 May 2021
Topic Review
Will
Will, generally, is a faculty of the mind - within philosophy, will is important as one of the parts of the mind, along with reason and understanding. It is considered central to the field of ethics because of its role in enabling deliberate action. One of the recurring questions discussed in the Western philosophical tradition is that of free will - and the related, but more general notion of fate - which asks how the will can be truly free if a person's actions have either natural or divine causes which determine them. In turn, this is directly connected to discussions on the nature of freedom and to the problem of evil.
  • 2.6K
  • 11 Oct 2022
Topic Review
Web-Based Orthopedic Personalized Predictive Tools
Web-based personalized predictive tools in orthopedic surgery are becoming more widely available. Despite rising numbers of these tools, many orthopedic surgeons may not know what tools are available, how these tools were developed, and how they can be utilized. The aim of this scoping review is to compile and synthesize the profile of existing web-based orthopedic tools. We conducted two separate PubMed searches—one a broad search and the second a more targeted one involving high impact journals—with the aim of comprehensively identifying all existing tools. These articles were then screened for functional tool URLs, methods regarding the tool’s creation, and general inputs and outputs required for the tool to function. We identified 57 articles, which yielded 31 unique web-based tools. These tools involved various orthopedic conditions (e.g., fractures, osteoarthritis, musculoskeletal neoplasias); interventions (e.g., fracture fixation, total joint arthroplasty); outcomes (e.g., mortality, clinical outcomes).
  • 445
  • 20 Nov 2020
Topic Review
Wearable Point-of-Care Devices
Personalized point-of-care testing (POCT) devices, such as wearable sensors, enable quick access to health monitoring without the use of complex instruments. Wearable sensors are gaining popularity owing to their ability to offer regular and continuous monitoring of physiological data by dynamic, non-invasive assessments of biomarkers in biofluids such as tear, sweat, interstitial fluid and saliva. 
  • 647
  • 09 May 2023
Topic Review
Wearable Piezoresistive, Inertial Sensors, RRM
The demand for wearable devices to measure respiratory activity is constantly growing, finding applications in a wide range of scenarios (e.g., clinical environments and workplaces, outdoors for monitoring sports activities, etc.). Particularly, the respiration rate (RR) is a vital parameter since it indicates serious illness (e.g., pneumonia, emphysema, pulmonary embolism, etc.). Therefore, several solutions have been presented in the scientific literature and on the market to make RR monitoring simple, accurate, reliable and noninvasive.
  • 669
  • 17 Sep 2021
Topic Review
Wearable Biosensors
Recent advances in lab-on-a-chip technology establish solid foundations for wearable biosensors. These newly emerging wearable biosensors are capable of non-invasive, continuous monitoring by miniaturization of electronics and integration with microfluidics. The advent of flexible electronics, biochemical sensors, soft microfluidics, and pain-free microneedles have created new generations of wearable biosensors that explore brand-new avenues to interface with the human epidermis for monitoring physiological status. However, these devices are relatively underexplored for sports monitoring and analytics, which may be largely facilitated by the recent emergence of wearable biosensors characterized by real-time, non-invasive, and non-irritating sensing capacities.
  • 1.9K
  • 18 Jan 2021
Topic Review
War on Cancer
The War on Cancer refers to the effort to find a cure for cancer by increased research to improve the understanding of cancer biology and the development of more effective cancer treatments, such as targeted drug therapies. The aim of such efforts is to eradicate cancer as a major cause of death. The signing of the National Cancer Act of 1971 by United States president Richard Nixon is generally viewed as the beginning of this effort, though it was not described as a "war" in the legislation itself. Despite significant progress in the treatment of certain forms of cancer (such as childhood leukemia), cancer in general remains a major cause of death 40+ years after this war on cancer began, leading to a perceived lack of progress and to new legislation aimed at augmenting the original National Cancer Act of 1971. New research directions, in part based on the results of the Human Genome Project, hold promise for a better understanding of the genetic factors underlying cancer, and the development of new diagnostics, therapies, preventive measures, and early detection ability. However, targeting cancer proteins can be difficult, as a protein can be undruggable.
  • 344
  • 18 Oct 2022
Topic Review
Von Willebrand Factor
The von Willebrand factor (vWF) is a plasma protein that mediates platelet adhesion and leukocyte recruitment to vascular injury sites and carries coagulation factor VIII, a building block of the intrinsic pathway of coagulation. A steep rise in shear rates, which may occur at sites of arterial stenosis and injury, is crucial for unfolding and activation of vWF. The hemostatic activity of vWF is counterbalanced by ADAMTS-13, a vWF-cleaving protease. The presence of ultra-large multimers of vWF in the bloodstream is associated with spontaneous thrombosis, whereas its deficiency leads to bleeding.
  • 1.0K
  • 12 Nov 2020
Topic Review
Vitamin B12 Deficiency Anemia
Vitamin B12 deficiency anemia, of which pernicious anemia (PA) is a type, is a disease in which not enough red blood cells are produced due to a deficiency of vitamin B12. The most common initial symptom is feeling tiredness and weakness. Other symptoms may include shortness of breath, pale skin, feeling like one may pass out (lightheadedness), chest pain, rapid heartbeat, numbness in the hands and feet, poor balance, a frequent fall of blood pressure, loss of appetite, a smooth red tongue, memory problems, poor reflexes, and in severe cases even depression and confusion. Without treatment some of these problems may become permanent. Pernicious anemia refers to anemia that results from lack of vitamin B12. Lack of intrinsic factor is most commonly due to an autoimmune attack on the cells that create it in the stomach. It can also occur following the surgical removal of part of the stomach or from an inherited disorder. Other causes of low vitamin B12 include not enough dietary intake (which can be a risk in a vegan diet), celiac disease, or tapeworm infection. When suspected, diagnosis is made by blood and, occasionally, bone marrow tests. Blood tests may show fewer but larger red blood cells, low numbers of young red blood cells, low levels of vitamin B12, and antibodies to intrinsic factor. Pernicious anemia can be treated with injections of vitamin B12. If the symptoms are severe, injections are typically recommended initially. For those who have trouble swallowing pills, a nasal spray is available. Often, treatment is lifelong. Pernicious anemia due to autoimmune problems occurs in about one per 1000 people. Among those over the age of 60, about 2% have the condition. It more commonly affects people of northern European descent. Women are more commonly affected than men. With proper treatment, most people live normal lives. Due to a higher risk of stomach cancer, those with pernicious anemia should be checked regularly for this. The first clear description was by Thomas Addison in 1849. The term "pernicious" means "deadly", and this term came into use because before the availability of treatment the disease was often fatal.
  • 1.2K
  • 27 Oct 2022
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