Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Polyphenol
The use of naturally derived drugs in anti-cancer therapies has grown exponentially in recent years. Among natural compounds, polyphenols have shown potential therapeutic applications in treatment due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties, resulting in beneficial effects on human health. Building more efficient cancer therapies with fewer side effects on human health can be achieved by combining natural compounds with conventional drugs, which are typically more aggressive than natural chemicals with polyphenols.
  • 1.4K
  • 19 Jun 2023
Topic Review
Common Mycotoxins in Cereal Grains and Producing Fungi
Cereal grains are the most important food staples for human beings and livestock animals. They can be processed into various types of food and feed products such as bread, pasta, breakfast cereals, cake, snacks, beer, complete feed, and pet foods. However, cereal grains are vulnerable to the contamination of soil microorganisms, particularly molds. The toxigenic fungi/molds not only cause quality deterioration and grain loss, but also produce toxic secondary metabolites, mycotoxins, which can cause acute toxicity, death, and chronic diseases such as cancer, immunity suppression, growth impairment, and neural tube defects in humans, livestock animals and pets. 
  • 1.4K
  • 07 Aug 2023
Topic Review
Retrieval-Augmented Generation with Large Language Models in Nephrology
The integration of large language models (LLMs) into healthcare, particularly in nephrology, represents a significant advancement in applying advanced technology to patient care, medical research, and education. These advanced models have progressed from simple text processors to tools capable of deep language understanding, offering innovative ways to handle health-related data, thus improving medical practice efficiency and effectiveness. A significant challenge in medical applications of LLMs is their imperfect accuracy and/or tendency to produce hallucinations—outputs that are factually incorrect or irrelevant. This issue is particularly critical in healthcare, where precision is essential, as inaccuracies can undermine the reliability of these models in crucial decision-making processes. To overcome these challenges, various strategies have been developed. One such strategy is prompt engineering, like the chain-of-thought approach, which directs LLMs towards more accurate responses by breaking down the problem into intermediate steps or reasoning sequences. Another one is the retrieval-augmented generation (RAG) strategy, which helps address hallucinations by integrating external data, enhancing output accuracy and relevance. Hence, RAG is favored for tasks requiring up-to-date, comprehensive information, such as in clinical decision making or educational applications. 
  • 1.4K
  • 18 Mar 2024
Topic Review
Effect of Grain Size on B4C and β-SiC
Nanocrystalline materials are categorized as having average grain sizes below 100 nm with a larger volume fraction of grain boundaries (GBs), leading to significant changes in their mechanical, physical, and chemical properties. Lightweight polycrystalline ceramics possess promising physical, chemical, and mechanical properties, which can be used in a variety of important structural applications. However, these ceramics with coarse-grained structures are brittle and have low fracture toughness due to their rigid covalent bonding (more often consisting of high-angle grain boundaries) that can cause catastrophic failures. Owing to these failure mechanisms in polycrystalline ceramics, a reduction in grain size to a nano-regime, which is expected to enhance the combination of hardness (or strength), toughness, and ductility, provides a promising nanomechanical research direction compared to counterpart micro-sized polycrystalline ceramics. Apart from the effects of grain size itself, the mechanical properties of B4C and SiC also show high dependency on their properties such as composition variation, anisotropy, density, etc.
  • 1.4K
  • 28 Sep 2022
Topic Review
Remediation Solutions for AMDrainage
Acid Mine Drainage (AMD) is a toxic wastewater stream formed when oxygenated water comes into contact with exposed mine rock surfaces containing sulphide minerals. The formation of AMD is most prominent in abandoned mines where water accumulates in mine shafts and pits allowing exposure to sulphide minerals. The resulting AMD is typically characterised by a low pH with high concentrations of heavy metals and dissolved sulphate. When left untreated, AMD streams can cause severe environmental degradation, including the contamination of natural water bodies, destroying aquatic life and toxifying natural habitats. AMD remediation methods can be divided into two main categories, active treatment and passive treatment methods. Active treatment methods are characterised by process inputs such as energy, chemicals, labour and automated control, whereas passive remediation technologies require minimal process inputs and are mostly self-sustaining. Passive treatment methods are typically at source constructions comprising of a combination of naturally occurring geochemical, physical and biological processes.
  • 1.4K
  • 04 Aug 2021
Topic Review
Therapeutic Landscapes and Psychiatric Care Facilities
Healing environments have been defined as therapeutic landscapes (TL), where the physical and built environments, social conditions and human perceptions combine to produce an atmosphere which is conducive to healing. The environment in mental-healthcare facilities can influence health and recovery of service users and furthermore contribute to healthy workplaces for staff. The physical (built and natural), social, and symbolic dimensions of the therapeutic landscape can have positive and negative impacts. Therefore, the needs and characteristics of the different stakeholders have to be considered.
  • 1.4K
  • 10 Feb 2022
Topic Review
Nucleosome Structures Built from Highly Divergent Histones
In eukaryotes, genomic DNA is bound with histone proteins and packaged into chromatin. The nucleosome, a fundamental unit of chromatin, regulates the accessibility of DNA to enzymes involved in gene regulation. Structural analyses of chromatin architectures have been limited to evolutionarily related organisms. The amino acid sequences of histone proteins are highly conserved from humans to yeasts, but are divergent in the deeply branching protozoan groups, including human parasites that are directly related to human health. Certain large DNA viruses, as well as archaeal organisms, contain distant homologs of eukaryotic histone proteins. The divergent sequences give rise to unique and distinct nucleosome architectures, although the fundamental principles of histone folding and DNA contact are highly conserved. 
  • 1.4K
  • 27 Sep 2022
Topic Review
Prosthetics
A prosthetic is an artificial device to replace missing or lost limbs; these instances are mainly contributed to amputation. 
  • 1.4K
  • 14 Jun 2023
Topic Review
Molecular Design of Porphyrin-Based Covalent Organic Frameworks
Chemical modification and self-assembly of molecules as well as constructing porphyrin-based metal (covalent) organic frameworks are often used to improve its solar light utilization and electron transfer rate. Especially porphyrin-based covalent organic frameworks (COFs) in which porphyrin molecules are connected by covalent bonds combine the structural advantages of organic frameworks with light-capturing properties of porphyrins and exhibit great potential in light-responsive materials. 
  • 1.4K
  • 10 May 2023
Topic Review
Famous Photographical Manipulations
Photographical Manipulation is the alteration of a photograph. The U.S. National Press Photographers Association (NPPA) Digital Manipulation Code of Ethics states: “As journalists we believe the guiding principle of our profession is accuracy; therefore, we believe it is wrong to alter the content of a photograph in any way that deceives the public. As photojournalists, we have the responsibility to document society and to preserve its images as a matter of historical record. It is clear that the emerging electronic technologies provide new challenges to the integrity of photographic images... in light of this, we the National Press Photographers Association, reaffirm the basis of our ethics: Accurate representation is the benchmark of our profession. We believe photojournalistic guidelines for fair and accurate reporting should be the criteria for judging what may be done electronically to a photograph. Altering the editorial content... is a breach of the ethical standards recognized by the NPPA.”
  • 1.4K
  • 17 Oct 2022
Topic Review
BDNF expression in GABAergic interneurons
Brain-derived neurotrophic factor (BDNF) is a major neuronal growth factor that is widely expressed in the central nervous system. It is synthesized as a glycosylated precursor protein, (pro)BDNF and post-translationally converted to the mature form, (m)BDNF. BDNF is known to be produced and secreted by cortical glutamatergic principal cells (PCs); however, it remains a question whether it can also be synthesized by other neuron types, in particular, GABAergic interneurons (INs). Therefore, we utilized immunocytochemical labeling and reverse transcription quantitative PCR (RT-qPCR) to investigate the cellular distribution of proBDNF and its RNA in glutamatergic and GABAergic neurons of the mouse cortex. Immunofluorescence labeling revealed that mBDNF, as well as proBDNF, localized to both the neuronal populations in the hippocampus. The precursor proBDNF protein showed a perinuclear distribution pattern, overlapping with the rough endoplasmic reticulum (ER), the site of protein synthesis. RT-qPCR of samples obtained using laser capture microdissection (LCM) or fluorescence-activated cell sorting (FACS) of hippocampal and cortical neurons further demonstrated the abundance of BDNF transcripts in both glutamatergic and GABAergic cells. Thus, our data provide compelling evidence that BDNF can be synthesized by both principal cells and INs of the cortex.
  • 1.4K
  • 26 Oct 2020
Topic Review
Chromosome 20
Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 20, one copy inherited from each parent, form one of the pairs.
  • 1.4K
  • 24 Dec 2020
Topic Review
Last Four Decades' Viral Pandemics
The last four decades have witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012), Ebola virus (2013) and the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) (2019-present). Age- and gender-based characterizations suggest that SARS-CoV-2 resembles SARS-CoV and MERS-CoV with regard to higher fatality rates in males, and in the older population with comorbidities. The invasion-mechanism of SARS-CoV-2 and SARS-CoV, involves binding of its spike protein with angiotensin-converting enzyme 2 (ACE2) receptors; MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4), whereas H1N1 influenza is equipped with hemagglutinin protein.
  • 1.4K
  • 08 Jan 2021
Topic Review
Treatment Strategies for Glioblastoma Multiforme
Immunotherapies represent a promising strategy for glioblastoma multiforme (GBM) treatment. Different immunotherapies include the use of checkpoint inhibitors, adoptive cell therapies such as chimeric antigen receptor (CAR) T cells, and vaccines such as dendritic cell vaccines. Antibodies have also been used as toxin or radioactive particle delivery vehicles to eliminate target cells in the treatment of GBM. Oncolytic viral therapy and other immunogenic cell death-inducing treatments bridge the antitumor strategy with immunization and installation of immune control over the disease. These strategies should be included in the standard treatment protocol for GBM. Some immunotherapies are individualized in terms of the medicinal product, the immune target, and the immune tumor–host contact. Current individualized immunotherapy strategies focus on combinations of approaches. Standardization appears to be impossible in the face of complex controlled trial designs.
  • 1.4K
  • 24 Jan 2021
Topic Review
Eukaryotic Cell
Eukaryotic cells, are complex cells that evolved through endosymbiosis when one cell (typically bacterial, forming mitochondria and plastids) is incorporated by a host cell. It might well be that other cellular organelles are also of endosymbiotic nature. 
  • 1.4K
  • 18 Mar 2021
Topic Review
Massive MIMO Techniques for 5G
The general concept of massive MIMO is defined as a physical-layer technology which equips each BS with a huge number of active antennas that can be used to spatially multiplex many UEs so that it is possible to communicate with them on the same time-frequency resource. The spectral efficiency per cell can be improved by orders-of magnitude over classical cellular networks by coping with the signal attenuation and interference through spatial signal processing with techniques such as receive combining and transmit precoding. To resume, massive MIMO is an upgraded version of the Space-Division Multiple Access (SDMA), pushing the spatial multiplexing to an extreme level.
  • 1.4K
  • 12 Aug 2021
Topic Review
The Effect of International Traffic on Malaria Cases
The stagnation of international traffic due to countermeasures against COVID-19 potentially reduced malaria cases by 58% in 2020 in Japan. International traffic was stagnated due to the COVID-19 pandemic, but international travel is slowly picking up from very low levels. We need to promote the preparation for the rebound of imported malaria cases in response to the normalization of international traffic.
  • 1.4K
  • 17 Jan 2022
Topic Review
Genetic Engineering Technology
Genetic engineering refers to the specific molecular biological modification of DNA sequences. With the rapid development of genetic engineering methods, especially the breakthroughs in guiding endonuclease technology, gene remodeling of crops has become simpler, more precise, and efficient. Genetic engineering techniques can be used to develop crops with superior traits such as high trace elements and high plant nutrients, providing an important tool to meet the needs of nearly 7.6 billion people in the world for crop yield and quality and to achieve sustainable development.
  • 1.4K
  • 13 Apr 2022
Topic Review
Business Recommender Systems
Besides the typical applications of recommender systems in B2C scenarios such as movie or shopping platforms, there is a rising interest in transforming the human-driven advice provided, e.g., in consultancy via the use of recommender systems. There are two main classes of recommender systems: information-filtering-based and knowledge-based systems. The former category selects items from a large collection of items based on user preferences and is further classified as collaborative-filtering recommenders and content-based filtering recommenders. The knowledge-based recommenders make recommendations by applying constraints or similarities based on domain or contextual knowledge. Common applications are in B2C scenarios such as e-commerce, tourism, news, movie, music, etc.
  • 1.4K
  • 10 Jun 2022
Topic Review
NDIS Participants with Psychosocial Disabilities and Life-Limiting Diagnoses
Australia’s National Disability Insurance Scheme (NDIS) is a key reform providing support to the disability population nationally. No peer-reviewed or grey literature was retrieved on the phenomena. Therefore, three lines of enquiry were developed: experiences of NDIS participants living with psychosocial disabilities; the death, dying, and palliative care supports and experiences of NDIS participants of any disability type; and the experiences for people living with severe and persistent mental illness (SPMI) and life-limiting diagnoses. 
  • 1.4K
  • 09 Sep 2022
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback