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Topic Review
Immunoformulation for COVID-19
The number of patients infected with the SARS-CoV-2 is still growing worldwide, with no current vaccine or medicinal treatment up to this date. Here we describe the cases of four COVID-19 patients that used a combination of therapeutic/nutraceutical agents for improvement of their symptoms. The ingredients were: immune transfer factor (oligo- and polypeptides fractions from porcine spleen, ultrafiltered at <10 kDa; Imuno TF®), anti-inflammatory natural blend (Uncaria tomentosa, Endopleura uchi and Haematoccocus pluvialis; Miodesin®), zinc, selenium, ascorbic acid, cholecalciferol, ferulic acid, spirulina, N-acetylcysteine, glucosamine sulfate potassium hydrochloride, trans-resveratrol, and maltodextrin-stabilized orthosilicic acid (SiliciuMax®). The four showed improvement in general symptoms after using the combination proposed here. The cases presented here are just a first hint towards its benefit (decreases time necessary for the recovery of the patients), this would be a good starting point to the further investigation of this possible add-on therapy in controlled clinical studies. Limited sample size and study design are limitations for definitive conclusions on the add-on therapy.
  • 5.9K
  • 05 Nov 2020
Topic Review
Wood Formation in Plants
Unlike herbaceous plants, woody plants undergo volumetric growth (a.k.a. secondary growth) through wood formation, during which the secondary xylem (i.e., wood) differentiates from the vascular cambium. Wood is the most abundant biomass on Earth and, by absorbing atmospheric carbon dioxide, functions as one of the largest carbon sinks. As a sustainable and eco-friendly energy source, lignocellulosic biomass can help address environmental pollution and the global climate crisis.
  • 5.9K
  • 15 Jul 2022
Topic Review
Dynamic-Maturational Model of Attachment and Adaptation
The dynamic-maturational model of attachment and adaptation (DMM) is a transdisciplinary model describing the effect attachment relationships can have on human development and functioning. It is especially focused on the effects of relationships between children and parents and between romantic/reproductive couples. It developed initially from attachment theory as developed by John Bowlby and Mary Ainsworth, and incorporated many other theories into a comprehensive model of adaptation to life's many dangers. The DMM was initially created by developmental psychologist Patricia McKinsey Crittenden and her colleagues including David DiLalla, Angelika Claussen, Andrea Landini, Steve Farnfield, and Susan Spieker. A main tenant of the DMM is that exposure to danger drives neural development and adaptation to promote survival. Danger includes relationship danger. In DMM-attachment theory, when a person needs protection or comfort from danger from a person with whom they have a protective relationship, the nature of the relationship generates relation-specific self-protective strategies. These are patterns of behavior which include the underlying neural processing. The DMM protective strategies describe aspects of the parent-child relationship, romantic relationships, and to a degree, relationships between patients/clients and long-term helping professionals.
  • 5.9K
  • 22 Nov 2022
Topic Review
Electric Vehicle Charger Cybersecurity Vulnerabilities
Worldwide growth in electric vehicle use is prompting new installations of private and public electric vehicle supply equipment (EVSE). EVSE devices support the electrification of the transportation industry but also represent a linchpin for power systems and transportation infrastructures. Cybersecurity researchers have identified several vulnerabilities that exist in EVSE devices, communications to electric vehicles (EVs), and upstream services, such as EVSE vendor cloud services, third-party systems, and grid operators. 
  • 5.9K
  • 02 Jun 2022
Topic Review
Division of Labour
The division of labour is the separation of tasks in any economic system or organisation so that participants may specialise (specialisation). Individuals, organizations, and nations are endowed with or acquire specialised capabilities and either form combinations or trade to take advantage of the capabilities of others in addition to their own. Specialised capabilities may include equipment or natural resources as well as skills and training and combinations of such assets acting together are often important. For example, an individual may specialise by acquiring tools and the skills to use them effectively just as an organization may specialize by acquiring specialised equipment and hiring or training skilled operators. The division of labour is the motive for trade and the source of economic interdependence. Historically, an increasing division of labour is associated with the growth of total output and trade, the rise of capitalism, and the increasing complexity of industrialised processes. The concept and implementation of division of labour has been observed in ancient Sumerian (Mesopotamian) culture, where assignment of jobs in some cities coincided with an increase in trade and economic interdependence. Division of labour generally also increases both producer and individual worker productivity. After the Neolithic Revolution, pastoralism and agriculture led to more reliable and abundant food supplies, which increased the population and led to specialisation of labour, including new classes of artisans, warriors, and the development of elites. This specialistion was furthered by the process of industrialisation, and Industrial Revolution-era factories. Accordingly, many classical economists as well as some mechanical engineers such as Charles Babbage were proponents of division of labour. Also, having workers perform single or limited tasks eliminated the long training period required to train craftsmen, who were replaced with lesser paid but more productive unskilled workers.
  • 5.9K
  • 17 Oct 2022
Topic Review
Waste Treatment Using Black Soldier Fly
Poor waste management has adverse impacts on the environment and human health. The recent years have seen increasing interest in using black soldier fly (BSF), Hermetia illucens, as an organic waste converter. Black soldier fly larvae (BSFL) feed voraciously on various types of organic waste, including food wastes, agro-industrial by-products, and chicken and dairy manure, and reduce the initial weight of the organic waste by about 50% in a shorter period than conventional composting. The main components of the BSFL system are the larvero, where the larvae feed and grow, and the fly house, where the adults BSF live and reproduce.
  • 5.9K
  • 28 Apr 2022
Topic Review
Dosage Compensation
Dosage compensation is the process by which organisms equalize the expression of genes between members of different biological sexes. Across species, different sexes are often characterized by different types and numbers of sex chromosomes. In order to neutralize the large difference in gene dosage produced by differing numbers of sex chromosomes among the sexes, various evolutionary branches have acquired various methods to equalize gene expression among the sexes. Because sex chromosomes contain different numbers of genes, different species of organisms have developed different mechanisms to cope with this inequality. Replicating the actual gene is impossible; thus organisms instead equalize the expression from each gene. For example, in humans, females (XX) silence the transcription of one X chromosome of each pair, and transcribe all information from the other, expressed X chromosome. Thus, human females have the same number of expressed X-linked genes as do human males (XY), both sexes having essentially one X chromosome per cell, from which to transcribe and express genes. There are three main mechanisms of achieving dosage compensation which are widely documented in the literature and which are common to most species. These include random inactivation of one female X chromosome (as observed in Mus musculus; this is called X-inactivation), a two-fold increase in the transcription of a single male X chromosome (as observed in Drosophila melanogaster), and decreased transcription by half in both of the X chromosomes of a hermaphroditic organism (as observed in Caenorhabditis elegans). These mechanisms have been widely studied and manipulated in model organisms commonly used in the laboratory research setting. A summary of these forms of dosage compensation is illustrated below. However, there are also other less common forms of dosage compensation, which are not as widely researched and are sometimes specific to only one species (as observed in certain bird and monotreme species).
  • 5.9K
  • 31 Oct 2022
Topic Review
Agriculture Robotics
Agricultural robotics aims to overcome the challenges imposed by population growth, accelerated urbanization, high competitiveness of high-quality products, environmental preservation and a lack of qualified labor. The main existing applications of agricultural robotic systems are for the execution of land preparation before planting, sowing, planting, plant treatment, harvesting, yield estimation and phenotyping.
  • 5.9K
  • 05 May 2021
Topic Review
Location-Based Social Networks
There are several definitions for “geosocial network” or “location-based social network”: the first formal definition was given by Quercia et al. in 2010, who defined it as “a type of social networking in which geographic services and capabilities such as geocoding and geotagging are used to enable additional social dynamics”. One year later, Zheng refined this definition by stating that “a location-based social network (LBSN) does not only mean adding a location to an existing social network so that people in the social structure can share location embedded information but also consists of the new social structure made up of individuals connected by the interdependency derived from their locations in the physical world as well as their location-tagged media content, such as photos, video, and texts”. In 2013, Roick and Heuser defined LBSNs simply as “social network sites that include location information into shared contents”. Finally, one most recent definition is given by Armenatzoglou and Papadias and is the following: “geosocial network (GeoSN) is an online social network augmented by geographical information”.
  • 5.9K
  • 17 Jan 2022
Topic Review
Online Auction
An online auction is an auction which is held over the internet. Online auctions come in many different formats, but most popularly they are ascending English auctions, descending Dutch auctions, first-price sealed-bid, Vickrey auctions, or sometimes even a combination of multiple auctions, taking elements of one and forging them with another. The scope and reach of these auctions have been propelled by the Internet to a level beyond what the initial purveyors had anticipated. This is mainly because online auctions break down and remove the physical limitations of traditional auctions such as geography, presence, time, space, and a small target audience. This influx in reachability has also made it easier to commit unlawful actions within an auction. In 2002, online auctions were projected to account for 30% of all online e-commerce due to the rapid expansion of the popularity of the form of electronic commerce. Online auctions include business to business (B2B), business to consumer (B2C), and consumer to consumer (C2C) auctions. The largest online auction site is eBay, which was the first to support person-to-person transactions. Other popular examples of online auction sites include WebStore, OnlineAuction and Overstock.
  • 5.9K
  • 06 Dec 2022
Topic Review
D-10 Tank Gun
The D-10 is a Soviet 100 mm tank gun developed in late World War II. It originally equipped the SU-100 tank destroyers and was later selected for the T-55 tank, equipping these as late as 1979. On the T-55 the D-10 continues to be in active service in many countries.
  • 5.9K
  • 19 Oct 2022
Topic Review
Polyoxymethylene
Polyoxymethylene (POM) is a material able to provide tooth-colored esthetics and that is suitable for fabrication of frameworks for removable dental prostheses. POM can be characterized as both polyethers (-C-O-) as well as polyacetals (-O-C-O-).
  • 5.9K
  • 29 Apr 2021
Topic Review
Amino Acid Catabolism
Amino acids have been extensively studied in nutrition, mainly as key elements for maintaining optimal protein synthesis in the body as well as precursors of various nitrogen-containing compounds. However, it is now known that amino acid catabolism is an important element for the metabolic control of different biological processes, although it is still a developing field to have a deeper understanding of its biological implications. The mechanisms involved in the regulation of amino acid catabolism now include the contribution of the gut microbiota to amino acid oxidation and metabolite generation in the intestine, the molecular mechanisms of transcriptional control, and the participation of specific miRNAs involved in the regulation of amino acid degrading enzymes. In addition, molecules derived from amino acid catabolism play a role in metabolism as they are used in the epigenetic regulation of many genes.
  • 5.9K
  • 02 Aug 2023
Topic Review
French Geodesic Mission
The French Geodesic Mission (also called the Geodesic Mission to Peru, Geodesic Mission to the Equator and the Spanish-French Geodesic Mission) was an 18th-century expedition to what is now Ecuador carried out for the purpose of measuring the roundness of the Earth and measuring the length of a degree of latitude at the Equator. The mission was one of the first geodesic (or geodetic) missions carried out under modern scientific principles, and the first major international scientific expedition.
  • 5.9K
  • 19 Oct 2022
Topic Review Peer Reviewed
Frederick II of Hohenstaufen (1208–1250)
Frederick II of Hohenstaufen, King of Sicily (1208–1250). Frederick II of Hohenstaufen was the second king of the Swabian dynasty to sit on the throne of Sicily. He was crowned in 1198, but, in consideration of his young age, he only ruled independently from 1208 to 1250 (the year of his death). He not only held the title of King of Sicily but also was the King of Germany (or of the Romans), the King of Jerusalem, and, above all, Emperor of the Holy Roman Empire. His most relevant and innovative iconographic representations were in Southern Italy. For this reason, we focus on the images in this geographical context. In particular, we have nine official (that is, those commissioned directly by him or his entourage) representations of him: the bull (in three main versions), the seal (in three main versions), five coins (four denari and one augustale), the statue of the Capua Gate, and the lost image of the imperial palace in Naples.
  • 5.9K
  • 13 Apr 2022
Topic Review
Post-Study System Usability Questionnaire
The Post-Study System Usability Questionnaire (PSSUQ) is an evaluation tool used to assess perceived usability, and it does not require a license for its usage. As PSSUQ is a common and widely used usability tool it has been translated into many languages, mainly European.
  • 5.9K
  • 20 Sep 2023
Topic Review
Fiscal Year
A fiscal year (or financial year, or sometimes budget year) is used in government accounting, which varies between countries, and for budget purposes. It is also used for financial reporting by businesses and other organizations. Laws in many jurisdictions require company financial reports to be prepared and published on an annual basis, but generally do not require the reporting period to align with the calendar year (1 January to 31 December). Taxation laws generally require accounting records to be maintained and taxes calculated on an annual basis, which usually corresponds to the fiscal year used for government purposes. The calculation of tax on an annual basis is especially relevant for direct taxation, such as income tax. Many annual government fees—such as Council rates, license fees, etc.—are also levied on a fiscal year basis, while others are charged on an anniversary basis. Some companies—such as Cisco Systems—end their fiscal year on the same day of the week each year, i.e. the day that is closest to a particular date (for example, the Friday closest to 31 December). Under such a system, some fiscal years will have 52 weeks and others 53 weeks. The calendar year is used as the fiscal year by about 65% of publicly traded companies in the United States and for a majority of large corporations in the UK. It's the case in many countries around the world with a few exceptions, for example, Australia, New Zealand, and Japan. Many universities have a fiscal year which ends during the summer to align the fiscal year with the academic year (and, in some cases involving public universities, with the state government's fiscal year), and because the university is normally less busy during the summer months. In the northern hemisphere this is July to the next June. In the southern hemisphere this is calendar year, January to December. Some media/communication-based organizations use a broadcast calendar as the basis for their fiscal year. The fiscal year is usually denoted by the calendar year in which it ends, so United States federal government spending incurred on 14 November 2022 would belong to fiscal year 2023, operating on a fiscal calendar of October–September.
  • 5.9K
  • 11 Oct 2022
Topic Review
Sallekhana
Sallekhana (IAST: sallekhanā), also known as Samlehna, Santhara, Samadhi-marana or Sanyasana-marana; is a supplementary vow to the ethical code of conduct of Jainism. It is the religious practice of voluntarily fasting to death by gradually reducing the intake of food and liquids. It is viewed in Jainism as the thinning of human passions and the body, and another means of destroying rebirth-influencing karma by withdrawing all physical and mental activities. It is not considered as a suicide by Jain scholars because it is not an act of passion, nor does it deploy poisons or weapons. After the sallekhana vow, the ritual preparation and practice can extend into years. Sallekhana is a vow available to both for Jain ascetics and householders. Historic evidence such as nishidhi engravings suggest sallekhana was observed by both men and women, including queens, in Jain history. However, in the modern era, death through sallekhana has been a relatively uncommon event. There is debate about the practice from a right to life and a freedom of religion viewpoint. In 2015, the Rajasthan High Court banned the practice, considering it suicide. Later that year, the Supreme Court of India stayed the decision of the Rajasthan High Court and lifted the ban on Sallekhana.
  • 5.9K
  • 10 Nov 2022
Topic Review
Football Goalkeeper Injuries
Knowledge and research about football goalkeeper (GK) injuries are scarce, which prevents the development of evidence-based injury prevention programs. Fortunately, progress is evident in injury prevention strategies in outfield football players. However, a GK fulfills a unique role, and an injured GK can substantially impact a team. Thus, there is a need to clarify and summarize current knowledge concerning football goalkeeper pain and injuries.
  • 5.9K
  • 31 May 2021
Topic Review
Mechanism of CRISPR/Cas Based Detection
In the pace of time, numerous platforms for rapid nucleic acid (NA) detection have been developed; however, they may not be able to satisfy the ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free and Deliverable to end-users) parameters set by the World Health of Organization at the same time. Recent studies have established that the CRISPR/Cas system possesses the potential to fulfil ASSURED criteria and demonstrated that it may be repurposed for the detection of contaminants, enzymes, proteins, analytes, and plant diseases, rather than being limited to clinical settings and nucleic acids. Several platforms have yet to be translated into clinical applications and must be brought into clinical settings from the laboratory. 
  • 5.9K
  • 08 Jun 2022
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