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Topic Review
Mannose Ligands for Mannose Receptor Targeting
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides. Furthermore, multivalent mannose presentation on the various templates like peptides, proteins, polymers, micelles, and dendrimers was proven to be a valuable approach for the selective and efficient delivery of various therapeutically active agents to MR. 
  • 1.5K
  • 20 Feb 2024
Topic Review
Pathophysiology and Clinical Manifestations of Secondary Syphilis
The subspecies T. pallidum pallidum is the cause of the most infamous sexually and congenitally transmitted disease, syphilis. This disease has an estimated incidence of six million infections every year. Multiple studies have noted that the prevalence of syphilis has been steadily increasing worldwide in recent decades, especially among men who have sex with men (MSMs) and HIV-positive patients. Clinically, syphilis presents in four stages with multiple different clinical manifestations.
  • 1.5K
  • 25 Apr 2023
Topic Review
NMR-Based Metabolomics in Metal-Based Drug Research
Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. Due to the low work-up required, high data reproducibility, and high throughput, NMR spectroscopy is an optimal detection technique in metabolomics studies.  The use of NMR-based metabolomic approaches in the investigation of a metal drug action mechanism or for assessing tumour response to anticancer metal agents is a recent, fast-growing tool. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. The future perspectives are even more interesting.  The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments. Moreover, NMR-based metabolomics could also play an important role in clinical trials, preventing or reducing unwanted side effects of metal anticancer drugs by the early detection of metabolic dysfunctions in bio-fluids. 
  • 1.5K
  • 15 Feb 2021
Topic Review
The European Labour Authority
On June 20, 2019, Regulation 2019/1140 was published in the Official Journal of the European Union. Under this Regulation, the European Labour Authority is established. The aim of the entry is to briefly explain the organisation and main functions of this new EU agency, using the relevant Regulation provisions and therefore underline its importance in the EU institutional system.
  • 1.5K
  • 30 Oct 2020
Topic Review
Auxin Regulates Primary Seed Dormancy
Phytohormone auxin acts as an outstanding coordinator of plant growth and development. Among other tasks, it has a key role as a signaling molecule that arranges seed life. Recently, auxin has emerged as an essential player that modulates the induction, regulation, and maintenance of primary seed dormancy (PSD). This function was supported by biochemical and genetic evidence. The participation of the transcriptional regulator ABSCISIC ACID (ABA) INSENSITIVE 3 (ABI3) is critical, which demonstrates a cross-talk between auxin and ABA signalings.
  • 1.5K
  • 30 Oct 2020
Topic Review
Micro-Computed Tomography
Micro-computed tomography (micro-CT) is a consolidated imaging technology allowing non-destructive three-dimensional (3D) qualitative and quantitative analysis by the observation of microstructures with high resolution. This paper Ten Years of Micro-CT in Dentistry and Maxillofacial Surgery: A Literature Overview aims at delivering a structured overview of literature about studies performed using micro-CT in dentistry and maxillofacial surgery (MFS) by analyzing the entire set of articles to portray the state of the art of the last ten years of scientific publications on the topic. 
  • 1.5K
  • 23 Feb 2021
Topic Review
Immunosuppressive Cells
Tumor-associated macrophages (TAMs) produce various chemokines and angiogenic factors that promote tumor development, along with other immunosuppressive cells. TAMs generated from monocytes develop into functional, fully activated macrophages, and TAMs obtain various immunosuppressive functions to maintain the tumor microenvironment. The main population of TAMs comprises CD163+ M2 macrophages, and CD163+ TAMs release soluble (s)CD163 and several proinflammatory chemokines as a result of TAM activation to induce an immunosuppressive tumor microenvironment. Since direct blockade of PD1/PD-L1 signaling between tumor cells and tumor-infiltrating T cells is mandatory to induce an anti-immune response by anti-PD1 Abs. Understanding the crosstalk between TAMs and immunosuppressive cells is important for optimizing PD1 Ab-based immunotherapy.
  • 1.5K
  • 03 Aug 2020
Topic Review
Seabed Mapping
Over the last few centuries, mapping the ocean seabed has been a major challenge for marine geoscientists. Knowledge of seabed bathymetry and morphology has significantly impacted our understanding of our planet dynamics. The history and scientific trends of seabed mapping can be assessed by data mining prior studies. Here, we have mined the scientific literature using the keyword “seabed mapping” to investigate and provide the evolution of mapping methods and emphasize the main trends and challenges over the last 90 years. An increase in related scientific production was observed in the beginning of the 1970s, together with an increased interest in new mapping technologies. The last two decades have revealed major shift in ocean mapping. The future of seabed mapping brings high expectations, considering that this is one of the main research and development themes for the United Nations Decade of the Oceans. We may expect a new higher resolution ocean seafloor map that might be as influential as The Floor of the Oceans map.
  • 1.5K
  • 25 Sep 2020
Topic Review
Efficient Structural Design with ANNs
Artificial Neural Networks (ANNs) are showing their potential as structural design tools. ANNs are applied to design a dry precast concrete connection. They can be easily and effectively adapted to different connection parameters, being possible to use them in both precast or cast in situ concrete connection design.
  • 1.5K
  • 27 Oct 2020
Topic Review
Intracellular pH Regulation in Muscle
Here we talk about the effects of acidosis on insulin signaling and glucose uptake in skeletal muscle and whether correcting defects that maintain [pH]i within the muscle, such as carnosine, could alleviate insulin resistance improve insulin responses during metabolic syndrome.
  • 1.5K
  • 22 Oct 2020
Topic Review
Thymoquinone in Cancers Therapy
To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As a bioactive compound of Nigella sativa, TQ has shown anticancer activities through the inhibition of cell proliferation, migration, and invasion. The anticancer efficacy of TQ is being investigated in several human cancers such as pancreatic cancer, breast cancer, colon cancer, hepatic cancer, cervical cancer, and leukemia.
  • 1.5K
  • 07 May 2021
Topic Review
Antimicrobial Resistance Surveillance Strategy in Uganda
Uganda is making strides and progress with regard to developing and implementing a functional AMR surveillance strategy for human health. Although numerous challenges still exist, following the laboratory health system strengthening approach, the readily addressable issues are with the health infrastructure, its integration, capacity building and operation. Antibiotic resistance and its mechanisms have now been in existance for over decades, and its drivers in both clinical, human, agriculture-veterinary go beyond the community and clinical aspects. Its noteworthy that the emergency of resistance is a natural phenomenon in the environment but kin to climate change. If left unchecked, this has great potential of undoing all medical and agricultural advancements of the entire previous century. Implementation of country driven program based surveillance that embraces a One Health Approach is the ideal approach to understanding and solving this one  health challenge that seems to be wicked in solve at the face mankind.
  • 1.5K
  • 30 Nov 2021
Topic Review
‘Cow Signs’ in Assessing the Quality of Nutrition
Cow signs are behavioral, physiological, and management parameters that can be observed and measured. Cow signs can be used as a field approach to evaluate the composition of the ration, the quality of rumen fermentation, the quality of digestion, and the general herd health of cattle of interest. This research of cow signs associated with nutrition provides farm advisors, consultants, nutritionists, practitioners, and dairy farmers with an additional toolkit that can be used to improve the assessment of the quality of dairy cattle nutrition. ‘Cow signs’ are not to be used alone as a sole tool for assessment of the quality or nutrition of dairy cows. Some of the ‘cow signs’ are incorporated in precision technologies on many dairy farms and are extensively used in the assessment of dairy cow welfare, health, and nutrition. 
  • 1.5K
  • 08 Jun 2022
Topic Review
Applications of Thermal Plasma Waste Treatment
Non-thermal as well as thermal plasmas are used for the processing of materials and waste. Thermal (hot) plasmas are characterized by their high energy density and by the equal temperatures of the electrons and the heavy particles, i.e., thermal plasmas are in local thermodynamic equilibrium. Non-thermal plasmas (also called cold plasmas), on the other hand, are non-equilibrium ionized gases, which are characterized by lower energy densities and by the large difference between the electron temperature and the temperature of the heavy particles.
  • 1.5K
  • 25 Jul 2022
Topic Review
Electropolymerization for Neuromorphic Engineering 
Electropolymerization is a bottom-up materials engineering process of micro/nanoscale that utilizes electrical signals to deposit conducting dendrites morphologies by a redox reaction in the liquid phase. It resembles synaptogenesis in the brain, in which the electrical stimulation in the brain causes the formation of synapses from the cellular neural composites. The strategy has been recently explored for neuromorphic engineering by establishing link between the electrical signals and the dendrites' shapes. Since the geometry of these structures determines their electrochemical properties, understanding the mechanisms that regulate polymer assembly under electrically programmed conditions is an important aspect, which is briefly reviewed here.
  • 1.5K
  • 15 Sep 2022
Topic Review
Thermoporometry and Cryoporometry
Thermoporometry and cryoporometry are methods for measuring porosity and pore-size distributions. A small region of solid melts at a lower temperature than the bulk solid, as given by the Gibbs–Thomson equation. Thus, if a liquid is imbibed into a porous material, and then frozen, the melting temperature will provide information on the pore-size distribution. The detection of the melting can be done by sensing the transient heat flows during phase transitions using differential scanning calorimetry – DSC thermoporometry, measuring the quantity of mobile liquid using nuclear magnetic resonance – NMR cryoporometry (NMRC) or measuring the amplitude of neutron scattering from the imbibed crystalline or liquid phases – ND cryoporometry (NDC). To make a thermoporometry / cryoporometry measurement, a liquid is imbibed into the porous sample, the sample cooled until all the liquid is frozen, and then warmed until all the liquid is again melted. Measurements are made of the phase changes or of the quantity of the liquid that is crystalline / liquid (depending on the measurement technique used). The techniques make use of the Gibbs–Thomson effect: small crystals of a liquid in the pores melt at a lower temperature than the bulk liquid : The melting point depression is inversely proportional to the pore size. The technique is closely related to that of use of gas adsorption to measure pore sizes but uses the Gibbs–Thomson equation rather than the Kelvin equation. They are both particular cases of the Gibbs Equations (Josiah Willard Gibbs): the Kelvin equation is the constant temperature case, and the Gibbs–Thomson equation is the constant pressure case.
  • 1.5K
  • 29 Sep 2022
Topic Review
In Vitro Models of the Blood–Cerebrospinal Fluid Barrier
The blood–cerebrospinal fluid (CSF) barrier (BCSFB), an under-studied brain barrier site compared to the blood–brain barrier (BBB), can be considered a potential therapeutic target to improve the delivery of CNS therapeutics and provide brain protection measures. Therefore, leveraging robust and authentic in vitro models of the BCSFB can diminish the time and effort spent on unproductive or redundant development activities by a preliminary assessment of the desired physiochemical behavior of an agent toward this barrier.
  • 1.5K
  • 30 Sep 2022
Topic Review
Chronic Kidney Disease in the Aging Population
The process of aging population will inevitably increase age-related comorbidities including chronic kidney disease (CKD). In light of this demographic transition, the lack of an age-adjusted CKD classification may enormously increase the number of new diagnoses of CKD in old subjects with an indolent decline in kidney function.
  • 1.5K
  • 11 Nov 2022
Topic Review
Physicochemical Properties of Stingless Bee Honey
Stingless bee honey (SLBH) has a high moisture content, making it more prone to fermentation and leading to honey spoilage. Dehydration of SLBH after harvest is needed to reduce the moisture content. This review compiles the available data on the dehydration methods for SLBH and their effect on its physicochemical properties.
  • 1.5K
  • 21 Nov 2022
Topic Review
Virtual Exchange
Virtual exchange is a type of education program that uses technology to allow geographically-separated people to interact and communicate. This type of activity is most often situated in educational programs (but is also found in some youth organizations) in order to increase mutual understanding, global citizenship, digital literacies, and language learning. Models of virtual exchange are also known as telecollaboration, online intercultural exchange, globally networked teaching and learning, collaborative online international learning (COIL). Non-profit organizations such as Soliya (founded by Lucas Welch) and the Sharing Perspectives Foundation have designed and implement virtual exchange programs in partnership with universities and youth organizations. In 2017 the European Commission published a feasibility study into virtual exchange and in 2018 the Erasmus+ Virtual Exchange project was launched in Europe and Southern Mediterranean countries. Educational institutions such as State University of New York's COIL Center and DePaul University use virtual exchange in higher education curricula to connect young people globally with a primary mission to help them grow in their understanding of each other's contexts (society, government, education, religion, environment, gender issues, etc.).
  • 1.5K
  • 21 Nov 2022
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