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Topic Review
EVOO’s Flavor
Extra virgin olive oil (EVOO) is one of the most distinctive ingredients of the Mediterranean diet. EVOO can be defined as the oil obtained from the fruit of the olive tree (Olea europaea), using exclusively mechanical or physical procedures. To obtain an EVOO, olives cannot be treated with other procedures than washing, decanting, centrifugation, and filtration, thus excluding oils obtained with solvents or by re-esterification or oil mixing procedures.
  • 690
  • 09 Mar 2021
Topic Review
Technology Training
The implementation of technology training is essential to promote the commercialization of research achievements, and can play a crucial role in poverty alleviation.
  • 690
  • 22 Jul 2021
Topic Review
Apicoplast Glutaredoxins in Neospora caninum
Glutaredoxins (GRXs), important components of the intracellular thiol redox system, are involved in multiple cellular processes. Previous study identified five GRXs in the apicomplexan parasite, Neospora caninum. This entry will confirm that the GRXs S14 and C5 are located in the apicoplast, which suggests unique functions for these proteins. Although single-gene deficiency did not affect the growth of parasites, a double knockout (Δgrx S14Δgrx C5) significantly reduced their reproductive capacity. However, there were no significant changes in redox indices (GSH/GSSG ratio, reactive oxygen species and hydroxyl radical levels) in double-knockout parasites, indicating that grx S14 and grx C5 are not essential for maintaining the redox balance in parasite cells. Key amino acid mutations confirmed that the Cys203 of grx S14 and Cys253/256 of grx C5 are important for parasite growth. Based on comparative proteomics, 79 proteins were significantly downregulated in double-knockout parasites, including proteins mainly involved in the electron transport chain, the tricarboxylic acid cycle and protein translation. Collectively, GRX S14 and GRX C5 coordinate the growth of parasites. However, considering their special localization, the unique functions of GRX S14 and GRX C5 need to be further studied.
  • 690
  • 29 Mar 2022
Topic Review
RFI as Efficiency Metric for Pre-Weaning Dairy Calves
Dairy cattle systems have targeted improvements in feed efficiency by selecting animals that can convert less feed into more products. Residual feed intake (RFI) has been the index of choice when selecting dairy cattle for feed efficiency. Nonetheless, RFI studies have focused on lactating cows, and the crucial importance of pre-weaning efficiency on farm profitability and cow productivity has been mostly neglected. Current results suggest great potential for selecting high-efficiency calves while in pre-weaning to accelerate the progress of genetic selection in dairy cattle.
  • 690
  • 25 Aug 2023
Topic Review
Dietary Chemical Components and Enteric Methane Production
Methanogenesis is critical in cattle because it prevents accumulation of metabolic hydrogen in the rumen by serving as a reducing equivalent sink. Alternative hydrogen sinks exist, however, and these alternative sinks are affected by the ingredient and chemical composition of the diet, such that the quantity of CH4 produced by cattle varies based on dietary constituents that are fed. Diets that produce acetate liberate hydrogen to be used by methanogenic archaea to produce CH4. Conversely, propionate serves as a net hydrogen sink, and diets that increase propionate and decrease acetate result in decreased ruminal CH4 production, reflecting decreased availability of metabolic hydrogen for methanogens to reduce CO2 to CH4.
  • 690
  • 19 Jan 2024
Topic Review
Androgen Receptor as Biomarker in Breast Cancer
Biomarkers can be used for diagnosis, prognosis, and prediction in targeted therapy. The estrogen receptor α (ERα) and human epidermal growth factor receptor 2 (HER2) are standard biomarkers used in breast cancer for guiding disease treatment. The androgen receptor (AR), a nuclear hormone receptor, contributes to the development and progression of prostate tumors and other cancers. With increasing evidence to support that AR plays an essential role in breast cancer, AR has been considered a useful biomarker in breast cancer, depending on the context of breast cancer sub-types. The existing survival analyses suggest that AR acts as a tumor suppressor in ER + ve breast cancers, serving as a favorable prognostic marker. However, AR functions as a tumor promoter in ER-ve breast cancers, including HER2 + ve and triple-negative (TNBC) breast cancers, serving as a poor prognostic factor. AR has also been shown to be predictive of the potential of response to adjuvant hormonal therapy in ER + ve breast cancers and to neoadjuvant chemotherapy in TNBC.  All contents are adapted from You, C.-P.; Leung, M.-H.; Tsang, W.-C.; Khoo, U.-S.; Tsoi, H. Androgen Receptor as an Emerging Feasible Biomarker for Breast Cancer. Biomolecules 2022, 12, 72. https://doi.org/10.3390/biom12010072
  • 689
  • 25 Jan 2022
Topic Review
Armed CAR-T or Combination Therapy for Prostate Cancer
CAR-T cells are genetically engineered T cells that express a unique fusion receptor. The receptor is composed of an extracellular domain, a hinge region, a transmembrane domain, and an intracellular signal transduction region.
  • 689
  • 28 Feb 2022
Topic Review
Pomacea canaliculata in China under Global Climate Change
Pomacea canaliculata is one of the 100 worst invasive alien species in the world, which has significant effects and harm to native species, ecological environment, human health, and social economy. Climate change is one of the major causes of species range shifts. With recent climate change, the distribution of P. canaliculata has shifted northward. Understanding the potential distribution under current and future climate conditions will aid in the management of the risk of its invasion and spread.
  • 688
  • 25 Jan 2022
Topic Review
Potential of Flow Cytometric Approaches in Food Industry
Microbial contamination, including the carryover of infectious microbes, is a global public health concern. An alternative technique that serves as a powerful, rapid, and highly sensitive method for the specific and non-specific detection, monitoring, enumeration, and characterization of microorganisms is flow cytometry (FCM).
  • 687
  • 12 Jan 2022
Topic Review
Climate Change and Plant Breeding
Plant breeding is, by definition, the art and science of changing the traits of plants through genetic improvements to produce desired characteristics for the benefit of humanity. Thus, plant breeding strives to use diverse genetic material to change the genetic composition of desirable plants/crops and select and multiply those with the highest attributes, structure, and nutrient composition for the most suitable uses related to human requirements. Crop yield has been a major target of plant breeding, although resistance and quality have also been important. Climate change calls for breeding efforts to improve characters in agricultural crops that can contribute to mitigating greenhouse gas (GHG) emissions. The assessment of plant characters has shown that an increased nutrient use efficiency is a major character that has a larger impact in decreasing the GHG emissions in wheat production.
  • 686
  • 31 Aug 2023
Topic Review
MATE Transporters Regulate Agronomic Traits
Multidrug and toxic compound extrusion (MATE) transporters are ancient proteins conserved among various kingdoms, from prokaryotes to eukaryotes. In plants, MATEs usually form a large family in the genome. Homologous MATE transporters have different subcellular localizations, substrate specificities, and responses to external stimuli for functional differentiations. The substrates of MATEs in plants include polyphenols, alkaloids, phytohormones, and ion chelators. The accumulation of these substrates is often associated with favorable agronomic traits such as seed and fruit colors, the balance between dormancy and germination, taste, and stress adaptability. In crops, wild germplasms and domesticated germplasms usually have contrasting agronomic traits such as seed color, seed taste, and stress tolerance. MATE transporters are involved in the regulations of these traits. 
  • 683
  • 05 May 2022
Topic Review
Vitamin D and Skeletal Muscle
Aging is associated with impairment in skeletal muscle mass and contractile function, predisposing to fat mass gain, insulin resistance and diabetes.  At cell and animal levels, that VitD treatments had positive effects on the development of muscle fibres in cells in culture, skeletal muscle force and hypertrophy. 
  • 681
  • 22 May 2021
Topic Review
Assessment of Brassicaceae Seeds Quality by X-ray Analysis
The seeds of cruciferous crops (Brassicaceae family) are high in fat oil (33–40%) and protein (25–36%). They are the main nutrients of the seed. 
  • 681
  • 11 Jan 2022
Topic Review
Small Non-Coding RNAs in Salmonella–Host Interactions
Salmonella species infect hosts by entering phagocytic and non-phagocytic cells, causing diverse disease symptoms, such as fever, gastroenteritis, and even death. Therefore, Salmonella has attracted much attention. Many factors are involved in pathogenesis, for example, the capsule, enterotoxins, Salmonella pathogenicity islands (SPIs), and corresponding regulators. These factors are all traditional proteins associated with virulence and regulation. Small non-coding RNAs (sRNAs) have also been reported to function as critical regulators. Salmonella has become a model organism for studying sRNAs. sRNAs regulate gene expression by imperfect base-pairing with targets at the post-transcriptional level. sRNAs are involved in diverse biological processes, such as virulence, substance metabolism, and adaptation to stress environments. 
  • 680
  • 19 Sep 2022
Topic Review
Phage Therapy on Human and Poultry Infection
Acinetobacter baumannii is a multidrug-resistant and invasive pathogen associated with the etiopathology of both an increasing number of nosocomial infections and is of relevance to poultry production systems. Phage therapy has gained particular importance for the treatment of bacterial infections. Phage therapy represents a potential treatment solution for multidrug-resistant Acinetobacter baumannii.
  • 680
  • 07 Nov 2022
Topic Review
Metabolic Diseases in Dairy Cattle: Subacute Ruminal Acidosis
This review paper provides an in-depth analysis of critical metabolic diseases affecting dairy cattle such as subacute ruminal acidosis (SARA). SARA represents a disorder of ruminal fermentation that is characterized by extended periods of depressed ruminal pH below 5.5–5.6. In the long term, dairy herds experiencing SARA usually exhibit secondary signs of the disease, such as episodes of laminitis, weight loss and poor body condition despite adequate energy intake, and unexplained abscesses usually 3–6 months after an episode of SARA. Depressed milk-fat content is commonly used as a diagnostic tool for SARA. A normal milk-fat test in Holstein dairy cows is >4%, so a milk-fat test of <3% can indicate SARA. However, bulk tank testing of milk fat is inappropriate to diagnose SARA at the herd level, so when >4 cows out of 12 and <60 days in milk are suspected to have SARA it can be considered that the herd has a problem. The rapid or abrupt introduction of fresh cows to high-concentrate diets is the most common cause of SARA. Changes in ruminal bacterial populations when exposed to higher concentrate rations require at least about 3 weeks, and it is recommended that concentrate levels increase by no more than 400 g/day during this period to avoid SARA. Throughout the review, emphasis is placed on the importance of early diagnosis and proactive management strategies to mitigate the impact of these metabolic diseases on dairy cattle health and productivity. The comprehensive nature of this paper aims to serve as a valuable resource for veterinarians, researchers, and dairy farmers seeking a deeper understanding of these prevalent metabolic disorders in dairy cattle.
  • 678
  • 14 Mar 2024
Topic Review
Panax ginseng CYP703
Cytochrome P450 (CYP) catalyzes a wide variety of monooxygenation reactions in plant primary and secondary metabolisms. Land plants contain CYP703, belonging to the CYP71 clan, which catalyzes the biochemical pathway of fatty acid hydroxylation, especially in male reproductive tissues. Korean/Asian ginseng (Panax ginseng Meyer) has been regarded as one of important medicinal plant for a long time, however the molecular mechanism is less known on its development.
  • 676
  • 07 Mar 2022
Topic Review
PeMNet for Pectoral Muscle Segmentation
Deep learning has become a popular technique in modern computer-aided (CAD) systems. In breast cancer CAD systems, breast pectoral segmentation is an important procedure to remove unwanted pectoral muscle in the images. This entry proposes a novel deep learning segmentation framework to provide fast and accurate pectoral muscle segmentation result. In the proposed framework, the novel network architecture enables more useful information to be used and therefore improve the segmentation results. 
  • 675
  • 17 Jan 2022
Topic Review
Melatonin in Brassicaceae
The family Brassicaceae, also known as Cruciferae, includes approximately 372 genera and 4060 species. It is distributed throughout the world, and its distribution pattern suggests that this plant family originated and was diversified from the eastern Mediterranean. Brassicaceae is a large family of plants that have a wide range of applications, including human consumption in vegetables, seed oils and condiments, livestock in fodder and others.Arabidopsis thaliana, which is well known in the research, belongs to this family.
  • 675
  • 09 Mar 2022
Topic Review
Production of Organic Milk
Milk is one of the most valuable products in the food industry with most milk production throughout the world being carried out using conventional management, which includes intensive and traditional systems. The intensive use of fertilizers, antibiotics, pesticides and concerns regarding animal health and the environment have given increasing importance to organic dairy and dairy products. 
  • 674
  • 05 Mar 2024
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