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Topic Review
Germ Cell Development
Mechanistic understanding of germ cell formation at a genome-scale level can aid in developing novel therapeutic strategies for infertility. Germ cell formation is a complex process that is regulated by various mechanisms, including epigenetic regulation, germ cell-specific gene transcription, and meiosis.
  • 2.0K
  • 11 Mar 2021
Topic Review
Potentiality of Vermicomposting
Vermicomposting is a biological process of decomposition of degradable residues through the digestive tracts of earthworms. It has been studied since long and still very important and relevant mostly in the viewpoint of organic waste recycling and biofertilizer production. Though wide range of literature are available on the topics, however, there are still unknowns that need to be additionally explored to maximize the potential of vermicompost.
  • 2.0K
  • 12 Nov 2021
Topic Review
Digital Face Manipulation Creation and Detection
Deepfake refers to the sophisticated manipulation of audiovisual content using deep learning techniques, particularly generative adversarial networks (GANs). It enables the creation of hyper-realistic fake videos or images by seamlessly superimposing one person's face or voice onto another's. These manipulated media raise significant concerns about misinformation, privacy invasion, and the potential to deceive audiences. Deepfakes have sparked discussions about the ethical implications of digital media manipulation and the challenges of distinguishing between genuine and fabricated content in the digital age. Efforts to counter deepfake technology involve developing advanced detection methods and raising awareness about the prevalence of manipulated media.
  • 2.0K
  • 25 Aug 2023
Topic Review
Empowerment Framework
The empowerment framework (EF) is a tool for capturing children’s involvement in their play environment and with their peers. It exposes what they are interested in and how they are learning through that process. The EF was designed as a conceptual framework, developed through PhD research with seven case-study children and families.
  • 2.0K
  • 07 Sep 2022
Topic Review
Green Public Procurement
Green Public Procurement (GPP) became an efficient instrument to achieve the objectives of environmental policy expressed by the European Commission in its Communications. At the same time, it must be addressed by the public authorities as a complex process, in which all purchased goods and services must integrate perfectly into an entire puzzle-like system of legislation, the construction field, innovation, healthcare, food, and education.
  • 2.0K
  • 10 Feb 2021
Topic Review
Complement System Activation and Functions
The complement system is an essential component of innate immunity. Acting as a first line of defence, the complement system recognises and aids in the elimination of pathogens. Complement proteins also play key roles in homeostasis and they support the inductive of the adaptive immune response.
  • 2.0K
  • 23 Mar 2021
Topic Review
Consolidated Bioprocessing
The long road from emerging biotechnologies to commercial “green” biosynthetic routes for chemical production relies in part on efficient microbial use of sustainable and renewable waste biomass feedstocks. One solution is to apply the consolidated bioprocessing approach, whereby microorganisms convert lignocellulose waste into advanced fuels and other chemicals. As lignocellulose is a highly complex network of polymers, enzymatic degradation or “saccharification” requires a range of cellulolytic enzymes acting synergistically to release the abundant sugars contained within. Complications arise from the need for extracellular localisation of cellulolytic enzymes, whether they be free or cell-associated.
  • 2.0K
  • 01 Jun 2021
Topic Review
Free Flaps in Burn Care
Microsurgical free flap reconstruction in acute burn care offers the option of reconstructing even challenging defects in a single stage procedure. Due to altered rheological and hemodynamic conditions in severely burned patients, it bears the risk of a higher complication rate compared to microsurgical reconstruction in other patients. To avoid failure, appropriate indications for free flap reconstruction should be reviewed thoroughly. Several aspects concerning timing of the procedure, individual flap choice, selection and preparation of the recipient vessels, and perioperative measures must be considered.
  • 2.0K
  • 28 Jul 2021
Topic Review
BiOCl and g-C3N4
Many organic pollutants are discharged into the environment, which results in the frequent detection of organic pollutants in surface water and underground water. Some of the organic pollutants can stay for a long time in the environment due to their recalcitrance. Advanced oxidation processes (AOPs) can effectively treat the recalcitrant organic compounds in water. Photocatalysis as one of the AOPs has attracted a lot of interest. BiOCl and g-C3N4 are nice photocatalysts. However, their catalytic activity should be further improved for industrial utilization. The construction of heterojunction between the two different components is deemed as an efficient strategy for developing a highly efficient photocatalyst. As a typical type-II heterojunction, g-C3N4/BiOCl heterojunctions showed better photocatalytic performance. To date, the g-C3N4/BiOCl composites were mainly studied in the field of water purification. The photoactivity of the pristine catalysts was greatly enhanced by the combination of the two materials. However, three kinds of proposed mechanisms were used to explain the improvement of the g-C3N4/BiOCl heterojunctions. But few researchers tried to explain why there were three different scenarios employed to explain the charge transfer. According to the articles reviewed, no direct evidence could indicate whether the band structures of the heterojunctions based on BiOCl and g-C3N4 were changed. Therefore, many more studies are needed to reveal the truth. Having a clearer understanding of the mechanism is beneficial for researchers to construct more efficient photocatalysts. This article is trying to start a new direction of research to inspire more researchers to prepare highly effective photocatalysts.
  • 2.0K
  • 15 Sep 2021
Topic Review
Soil Remediation Strategy
Although soil is a valuable and non-renewable ecological system, it has always been subject to widespread degradation due to anthropic activities. The most severe risks are point source and diffuse soil pollution. The remediation of contaminated soils and sites is, therefore, a significant step in the protection of the environment and living organisms, and must be included in the broader multidisciplinary scenario of strategic green transition.
  • 2.0K
  • 15 Feb 2022
Topic Review
Subcellular Localization of HSP90
Heat shock protein (HSP90), a highly conserved molecular chaperon, is indispensable for the maturation of newly synthesized poly-peptides and provides a shelter for the turnover of misfolded or denatured proteins.
  • 2.0K
  • 27 Sep 2022
Biography
Barnes Wallis
Sir Barnes Neville Wallis CBE FRS RDI FRAeS[1] (26 September 1887 – 30 October 1979), was an English scientist, engineer and inventor. He is best known for inventing the bouncing bomb used by the Royal Air Force in Operation Chastise (the "Dambusters" raid) to attack the dams of the Ruhr Valley during World War II. The raid was the subject of the 1955 film The Dam Busters, in which Wallis wa
  • 2.0K
  • 06 Dec 2022
Topic Review
Reconfigurable Intelligent Surfaces for 5G and beyond technologies
With possible new use cases and demanding requirements of future 5th generation (5G) and beyond cellular networks, the future of mobile communications sounds promising. However, the propagation medium has been considered a randomly acting agent between the transmitter and the receiver. With the advent of the digital age of wireless communications, the received signal quality is degrading due to the uncontrollable interactions of the transmitted radio waves with the surrounding artifacts. 
  • 2.0K
  • 23 Dec 2021
Topic Review
Wild Boar Carcass Characteristics and Meat Quality
Globally, wild boar is a primary food resource, mostly for remote rural communities outside of large urban centers located in Latin America, Asia, and Africa. In Chile, the production of meat from European wild boar (Sus scrofa L.) is expanding together with the export of this “exotic” meat. Furthermore, in the Finno-Scandinavian peninsula, and central and Mediterranean Europe, wild boar (Sus scrofa) and other game species meat (reindeer, red deer, roe deer, fallow deer, moose, and chamois) can be found in local restaurants and fairs, indicating an already consolidated gastronomic interest in this type of meat.
  • 2.0K
  • 24 Jul 2023
Topic Review
Regional Hydro-Ecological Simulation System
Regional Hydro-Ecological Simulation System (RHESSys), a distributed physical processes-based ecohydrological model, that can simulate the regional multi-components cycle of nitrogen, carbon, and water. Many RHESSys-based studies have been implemented for sustainable watershed management. 
  • 2.0K
  • 01 Apr 2021
Topic Review
Bacterial Cellulose
Bacterial cellulose (BC) is a natural polymer that has fascinating attributes, such as biocompatibility, low cost, and ease of processing, being considered a very interesting biomaterial due to its options for moldability and combination. 
  • 2.0K
  • 28 Jan 2021
Topic Review
Therapeutic Community
Therapeutic community is a participative, group-based approach to long-term mental illness, personality disorders and drug addiction. The approach was usually residential, with the clients and therapists living together, but increasingly residential units have been superseded by day units. It is based on milieu therapy principles, and includes group psychotherapy as well as practical activities. Therapeutic communities have gained some reputation for success in rehabilitation and patient satisfaction in Britain and abroad. In Britain, 'democratic analytic' therapeutic communities have tended to specialise in the treatment of moderate to severe personality disorders and complex emotional and interpersonal problems. The evolution of therapeutic communities in the United States has followed a different path with hierarchically arranged communities (or concept houses) specialising in the treatment of drug and alcohol dependence.
  • 2.0K
  • 02 Dec 2022
Topic Review
Hallmarks of Senescence
Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; the chronic accumulation of senescent cells contributes to tissue dysfunction and aging. Recognizing the hallmarks of senescence is crucial for the research and development of therapies against aging.
  • 2.0K
  • 20 Feb 2023
Topic Review
Peer-to-peer Files Sharing Networks
Peer-to-peer (P2P)  files sharing networks have been one of the most reliable platforms to realize the potential of network coding, since end hosts at the edge of the Internet have abundant computational resources with modern processors. In this survey paper, we extensively summarize, assess, compare, and classify the most recently used techniques to improve P2P content distribution systems performance using network coding. To the best of our knowledge, this survey is the first comprehensive survey that specifically focuses on the performance of network coding based P2P file sharing systems.
  • 2.0K
  • 29 Oct 2020
Topic Review
NK Cells in Cancer Therapy
       Cellular therapy has emerged as an attractive option for the treatment of cancer, and adoptive transfer of chimeric antigen receptor (CAR) expressing T cells has gained FDA approval in hematologic malignancy. However, limited efficacy was observed using CAR-T therapy in solid tumors. Natural killer (NK) cells are crucial for tumor surveillance and exhibit potent killing capacity of aberrant cells in an antigen-independent manner. Adoptive transfer of unmodified allogeneic or autologous NK cells has shown limited clinical benefit due to factors including low cell number, low cytotoxicity and failure to migrate to tumor sites. To address these problems, immortalized and autologous NK cells have been genetically engineered to express high affinity receptors (CD16), CARs directed against surface proteins (PD-L1, CD19, Her2, etc.) and endogenous cytokines (IL-2 and IL-15) that are crucial for NK cell survival and cytotoxicity, with positive outcomes reported by several groups both preclinically and clinically. With a multitude of NK cell-based therapies currently in clinic trials, it is likely they will play a crucial role in next-generation cell therapy-based treatment. In this review, we will highlight the recent advances and limitations of allogeneic, autologous and genetically enhanced NK cells used in adoptive cell therapy.
  • 2.0K
  • 30 Oct 2020
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