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Topic Review
LACE Index Predicts High Risk of 30-Day Readmission
The LACE index accounts for: Length of stay (L), Acuity of admission (A), Comorbidities (C), and recent Emergency department use (E).  The incorporation of a high-risk LACE index showed favorable risk prediction and could be applied to predict 30-day readmission with chronic conditions. 
  • 2.0K
  • 12 May 2022
Topic Review
Rate Response in Implantable Cardiac Pacemakers
Modern cardiac pacemakers are equipped with a function that allows the heart rate to adapt to the current needs of the patient in situations of increased demand related to exercise and stress ("rate-response" function). Modern pacemakers are equipped with a number of functions and algorithms that adjust the basal rate of pacing to situations associated with increased demands of the body—this requires sensors for accelerometer-based measurements; measurements of minute ventilation; measurements of myocardial contractility; and the analysis of myocardial, transthoracic, and transvalvular impedances.
  • 2.0K
  • 29 May 2023
Topic Review
Stride Length
Stride length was defined as the distance measured parallel to the line of progression, including two consecutive steps. Stride width was defined as side-to side distance between the heel of the current foot and heel of the next opposite foot. On the other hand, step width was determined as the distance between the outermost borders of two consecutive footprints. The standard deviation of the three variables (stride length) was used to represent the variability of the stride length.
  • 2.0K
  • 22 Jul 2021
Topic Review
Smart Hospitals and IoT Sensors: The Healthcare Future
Hospitals are already adopting sensor devices of many types to monitor medical processes. Patients and medical staff can now wear sensors that provide movement and health conditions information in near-real time. Additionally, many sensors can monitor physical settings generating information about the environment and medical equipment. This set of sensors has the potential to provide information to support decision-making processes and medical data analytics. Internet of Things (IoT) is spreading among several areas, paving the way to a new industrial revolution.
  • 2.0K
  • 20 Jul 2022
Topic Review
Amygdalin
Bioactive amygdalin, found in high concentrations in bitter almonds, has been recognized as a symbol of the cyanogenic glycoside chemical organic substance, which was initially developed as a pharmaceutical for treating cancer after being hydrolyzed to hydrogen cyanide (HCN).
  • 2.0K
  • 25 Oct 2022
Topic Review
Physical Activity, Sedentary Behavior and Wrist Accelerometer
The switch from hip-placed to wrist-worn accelerometers has signaled the focus on developing novel approaches to process raw acceleration data without overly relying on traditional cut points. Indeed, wrist-worn raw acceleration data have been increasingly utilized to capture individuals’ physical behavior patterns. Several traditional methods and cut points have been developed to deal with raw wrist acceleration data, yet they appear to either overestimate or underestimate the outcomes.
  • 2.0K
  • 22 Dec 2021
Topic Review
Leveraging Reddit for Suicidal Ideation Detection
Suicide is a major public-health problem that exists in virtually every part of the world. Hundreds of thousands of people commit suicide every year. The early detection of suicidal ideation is critical for suicide prevention. However, there are challenges associated with conventional suicide-risk screening methods. At the same time, individuals contemplating suicide are increasingly turning to social media and online forums, such as Reddit, to express their feelings and share their struggles with suicidal thoughts. 
  • 2.0K
  • 02 Nov 2022
Topic Review
Food Security Interventions among Refugees
There are 26 million refugees globally, with as many as 80% facing food insecurity irrespective of location. Humanitarian agencies continually provide assistance and evaluate their interventions in areas of refugee crisis. Researchers should adopt a standard feasible food security assessment tool which is needed to assess the effectiveness of interventions across locations and countries to develop best practices based on comparative results.
  • 2.0K
  • 24 Mar 2022
Topic Review
Pharmaceutical Care
Pharmaceutical care necessitates significant efforts from patients, informal caregivers, the interprofessional team of health care professionals and health care system administrators. Collaboration, mutual respect and agreement amongst all stakeholders regarding responsibilities throughout the complex process of pharmaceutical care is needed before patients can take full advantage of modern medicine. Based on the literature and policy documents, in this position paper, we reflect on opportunities for integrated evidence-based pharmaceutical care to improve care quality and patient outcomes from a nursing perspective.
  • 2.0K
  • 02 Jul 2021
Topic Review
Combating 131I Side Effects in Thyroid Cancer
Thyroid cancer is the most common endocrine cancer, and its prevalence has been increasing for decades. Approx. 95% of differentiated thyroid carcinomas are treated using 131iodine (131I), a radionuclide with a half-life of 8 days, to achieve optimal thyroid residual ablation following thyroidectomy. However, while 131I is highly enriched in eliminating thyroid tissue, it can also retain and damage other body parts (salivary glands, liver, etc.) without selectivity, and even trigger salivary gland dysfunction, secondary cancer, and other side effects. 
  • 1.9K
  • 29 Jun 2023
Topic Review
Brain Neurodegeneration and Cognitive Deficits after Cardiac Arrest
Cardiac arrest occurs as a result of a sudden stop of the heartbeat and its mechanical activity, which causes cessation of systemic circulation and blood flow in the brain, which triggers global brain ischemia. Brain neuropathology after cardiac arrest includes primary ischemic injury and secondary reperfusion injury, which occur sequentially, acutely during cardiac arrest and resuscitation, and chronically in the post-resuscitation stag.
  • 1.9K
  • 29 Feb 2024
Topic Review
Edible Insect-Based Foods in Europe
All over the world, a large proportion of the population consume insects as part of their diet. In Western countries, however, the consumption of insects is perceived as a negative phenomenon. The consumption of insects worldwide can be considered in two ways: on the one hand, as a source of protein in countries affected by hunger, while, on the other, as an alternative protein in highly-developed regions, in response to the need for implementing policies of sustainable development. This entry focused on both the regulations concerning the production and marketing of insects in Europe and the characteristics of edible insects that are most likely to establish a presence on the European market. The paper indicates numerous advantages of the consumption of insects, not only as a valuable source of protein but also as a raw material rich in valuable fatty acids, vitamins, and mineral salts.
  • 1.9K
  • 21 Apr 2021
Topic Review
Hyperacusis in Autism Spectrum Disorders
Decreased Sound Tolerance Disorders (DSTD) are routinely observed in autism spectrum disorder (ASD). The most common types of DSTD are hyperacusis and misophonia. Hyperacusis is a class of decreased sound tolerance disorders in which a negative or incongruous reaction is triggered from exposure to sounds that are not described as threatening or uncomfortable by a neurotypical individual. These reactions are in response to general sounds, rather than specific sounds (such as chewing and sniffling), as would be the case with misophonia. Hyperacusis can affect an individual at various degrees depending on the severity. It can impact one’s emotional wellbeing, sleep, concentration, and can cause anxiety.
  • 1.9K
  • 11 Nov 2021
Topic Review
Dietary Recommendations for Twin Pregnancy
Recommendations for nutrition and the use of dietary supplements for pregnant women are updated on regular basis but it remains to be seen to what extent they may be applicable in twin pregnancies. Over the past 30 years, there has been a considerable increase in the number of multiple pregnancies worldwide, which mainly applies to dizygotic pregnancies. In the USA, in 2009 compared to the 1980s, the number of twin pregnancies increased by 76%; the situation was similar in Australia (66%). A multiple pregnancy is associated with an increased risk of its abnormal course. This mostly applies to pre-eclampsia, hypertension, diabetes, iron-deficiency anemia and pre-term birth that affects 50–60% of twin pregnancies. 
  • 1.9K
  • 26 Apr 2022
Topic Review
Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) remains a poorly characterized syndrome with many unknown aspects related to different patient profiles, various associated risk factors and a wide range of aetiologies. It comprises several pathophysiological pathways, such as endothelial dysfunction, myocardial fibrosis, extracellular matrix deposition and intense inflammatory system activation.
  • 1.9K
  • 18 Jan 2023
Topic Review
Laboratory Diagnosis of Porphyria
Porphyrias are a group of diseases that are clinically and genetically heterogeneous and originate mostly from inherited dysfunctions of specific enzymes involved in heme biosynthesis.
  • 1.9K
  • 28 Sep 2021
Topic Review
Parental Attachment and Peer Relationships in Adolescence
Attachment theory is a social-emotional development theory that was originally developed by John Bowlby in order to explain the bond between babies and their caretakers. The basic premise is that an individual’s security and trust toward others in later life stages are molded by their experiences with relationship patterns and the emotional availability of their caretakers, that is to say, their attachment figures. Later, Ainsworth carried out some of the first studies on the individual differences which manifest in attachment, observing how this system is activated and discovering differences based on the behaviors of the caretakers. Through a standardized laboratory procedure called “strange situation”, Ainsworth recorded systematic observations on mother–child interactions in the first year of life, as well as the reaction of the child during separation from and reunion with the mother.
  • 1.9K
  • 27 Jan 2022
Topic Review
Probiotics, Prebiotics, and Phytogenic Substances for Gut Health
The gut microbiota has been designated as a hidden metabolic ‘organ’ because of its enormous impact on host metabolism, physiology, nutrition, and immune function. The connection between the intestinal microbiota and their respective host animals is dynamic and, in general, mutually beneficial. This complicated interaction is seen as a determinant of health and disease; thus, intestinal dysbiosis is linked with several metabolic diseases. Therefore, tractable strategies targeting the regulation of intestinal microbiota can control several diseases that are closely related to inflammatory and metabolic disorders. As a result, animal health and performance are improved. One of these strategies is related to dietary supplementation with prebiotics, probiotics, and phytogenic substances. These supplements exert their effects indirectly through manipulation of gut microbiota quality and improvement in intestinal epithelial barrier. 
  • 1.9K
  • 16 Feb 2022
Topic Review
Fall Risk Assessment Scales
Falls are recognized globally as a major public health problem. Although the elderly are the most affected population, it should be noted that the pediatric population is also very susceptible to the risk of falling. The fall risk approach is the assessment tool. There are different types of tools used in both clinical and territorial settings. 
  • 1.8K
  • 24 Jun 2021
Topic Review
Human Carcinogenicity of Ethylenedithiocarbamate Fungicides
In January 2021, the European Union ended the license of Mancozeb, the bestselling ethylenedithiocarbamate (EBDC) fungicide, because of some properties typical of human carcinogens. This decision contrasts the IARC classification of EBDC fungicides (Group 3, not classifiable as to human carcinogenicity). 
  • 1.8K
  • 15 Mar 2022
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