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Topic Review
Mental Health of Self-Employed
We included 26 (three longitudinal and 23 cross-sectional) population-based studies of good quality, with data from 3,128,877 participants in total. A Swedish national register evaluation with 25 years follow-up, showed a higher incidence of mental illness among the self-employed compared to white-collar workers, but a lower incidence compared to blue-collar workers. In the second longitudinal study from Sweden the self-employed had a lower incidence of mental illness compared to both blue- and white-collar workers over 15 years, whereas the third longitudinal study (South Korea) did not find a difference regarding the incidence of depressive symptoms over 6 years. A higher prevalence of mental disorders among the self-employed compared to employees was true for the Asian and older European cross-sectional studies. However, most of the European cross-sectional studies from the last decade found lower or similar prevalence estimates among the self-employed. The majority of the American and Australian cross-sectional studies found a similar prevalence of mental disorders among the self-employed and the employees.
  • 816
  • 28 Sep 2021
Topic Review
Skeletal Fluorosis
Fluorine is widely dispersed in nature and has multiple physiological functions. Although it is usually regarded as an essential trace element for humans, this view is not held universally. Moreover, chronic fluorosis, mainly characterized by skeletal fluorosis, can be induced by long-term excessive fluoride consumption. High concentrations of fluoride in the environment and drinking water are major causes, and patients with skeletal fluorosis mainly present with symptoms of osteosclerosis, osteochondrosis, osteoporosis, and degenerative changes in joint cartilage. Etiologies for skeletal fluorosis have been established, but the specific pathogenesis is inconclusive. Currently, active osteogenesis and accelerated bone turnover are considered critical processes in the progression of skeletal fluorosis. In recent years, researchers have conducted extensive studies in fields of signaling pathways (Wnt/β-catenin, Notch, PI3K/Akt/mTOR, Hedgehog, parathyroid hone, and insulin signaling pathways), stress pathways (oxidative stress and endoplasmic reticulum stress pathways), epigenetics (DNA methylation and non-coding RNAs), and their inter-regulation involved in the pathogenesis of skeletal fluorosis.
  • 813
  • 11 Nov 2021
Topic Review
Infectious Diseases Associated with Hydrometeorological Hazards in Europe
Hydrometeorological hazards comprise a wide range of events, mainly floods, storms, droughts, and temperature extremes. Floods account for the majority of the related disasters in both developed and developing countries. Flooding alters the natural balance of the environment and frequently establishes a favorable habitat for pathogens and vectors to thrive. Diseases caused by pathogens that require vehicle transmission from host to host (waterborne) or a host/vector as part of their life cycle (vector-borne) are those most likely to be affected by flooding. 
  • 809
  • 29 Aug 2022
Topic Review
Religion and Health in Macau
Macau, a Portuguese colony until 1999, remains a diversified culture because of its intermixed historical background from the East and the West. Through structural equation modelling, the analysis of data collected from a representative sample of Macau residents, using a multistage stratified sampling procedure, indicated a positive link between religiosity and health. Moreover, altruism and prejudice mediated a portion of the relationship between religiosity and health. Additionally, Macau residents who were more religious had a higher level of altruism and a lower level of prejudice. The link between religion and prejudice in Macau differs from that of many other cultures, indicating that the effect of religion on prejudice varies by cultural context.
  • 808
  • 14 Sep 2022
Topic Review
Genetically Modified Food
The concept of “genetically modified organisms” (GMOs) refers to those organisms whose genome has been altered by inserting a gene from another organism, removing a gene, or changing a gene’s function to generate a desirable trait.
  • 799
  • 25 Mar 2022
Topic Review
Health Benefits of Bread Fortification
Bread is among the most common foods for the world’s population. Therefore, it can be fortified to eliminate deficiencies of nutrients or be a carrier of other substances with a nutritional or physiological effect, bringing health benefits to its consumers, thus impacting sustainable health.
  • 799
  • 25 Oct 2023
Topic Review
Workplace Based Sampler Comparison Review
A narrative review on peer-reviewed literature reporting comparisons of personal samplers in workplace settings published between 2004 and 2020 was carried out. Search terms were developed for Web of Science and PubMed bibliographic databases. The retrieved studies were screened for relevance, with those studies meeting the inclusion criteria being taken forward to data extraction (22 studies). The inhalable fraction was the most common fraction assessed, with the IOM sampler being the most studied sampler. The most common workplace environment where samplers had been compared was that where metals/metalloids were present. The requirements of EN13205 standard (Workplace exposure. Assessment of sampler performance for measurement of airborne particle concentrations) have also been considered, with these requirements not currently being met, or at least referred to, in the reviewed literature. A number of conclusions have been drawn from this narrative review. For studies that reported correction factors, no discernible trends could be identified.
  • 797
  • 08 Jul 2021
Topic Review
Mechanism of Bone Loss Induced by Iron Deficiency
Iron is a vital component of various enzymes involved in many biological processes, including oxygen transport, DNA biosynthesis, and cellular energy generation. Moreover, the biological activity of iron depends mainly on its efficient electron transfer properties. It has the ability to accept or donate electrons during the conversion between ferric iron (Fe3+) and ferrous iron (Fe2+), thereby functioning as a catalytic cofactor in various biochemical reactions. Therefore, iron is necessary for the growth, proliferation, and differentiation of bone cells, especially for osteoblasts and osteoclasts. In addition, hypoxia caused by iron deficiency can also lead to the activity and function disorder of bone cells. With respect to bone metabolism, iron is involved in the synthetic process of collagen and vitamin D metabolism.
  • 796
  • 12 Apr 2023
Topic Review
Effect of Sanitizing Treatments on Respirator Filtration Performance
Disposable respirator masks with an accepted performance rating are seriously compromised from an exposure to saturated alcoholic vapours, can tolerate a one-off spray treatment with an alcoholic solution and retain their attested protection under the influence of alcoholic vapours from the use of hand sanitizer or spray sanitizer.
  • 795
  • 10 Jan 2022
Topic Review
Guinea Worm Disease
Dracunculiasis, also known as Guinea worm disease (GWD), is a neglected tropical disease (NTD) caused by a parasite (Dracunculus medinensis). In the past, dracunculiasis was known as “the disease of the empty granary” because of the difficulties patients had in going to work in fields or to school when affected by this disease. In tropical areas, the condition has been widespread in economically disadvantaged communities, and has been associated with reduced economic status and low levels of education. By development and optimization of multi-layered control measures, transmission by the vector has been interrupted, but there are foci in several African countries with a high risk of compromising the results obtained in the control of this neglected disease. 
  • 777
  • 25 Nov 2022
Topic Review
Effects of Particulate Matter on Inflammation and Thrombosis
Ambient air pollution has become a common problem worldwide. Exposure to pollutant particles causes many health conditions, having a particular impact on pulmonary and cardiovascular disease. Increased understanding of the pathological processes related to these conditions may facilitate the prevention of the adverse impact of air pollution on our physical health. 
  • 762
  • 04 Aug 2022
Topic Review
Lipoxygenases and Arachidonic Acid in Glioblastoma Multiforme
Glioblastoma multiforme is a brain tumor with a very unfavorable prognosis, where the vast majority of patients do not survive a year after diagnosis. Arachidonic acid ARA C20:4n-6 in humans is not synthesized de novo but from linoleic acid C18:2n-6 in the polyunsaturated fatty acid (PUFA) biosynthesis pathway. In addition to the cyclooxygenases (COX) pathway, PUFA can be transformed with lipoxygenases (LOX). These enzymes exhibit dioxygenase activity, catalyzing the insertion of a hydroperoxyl group into a PUFA, most commonly ARA 20:4n-6.
  • 747
  • 10 Feb 2023
Topic Review
Opioid Addiction Science and Society
Opioid abuse and misuse have led to an epidemic which is currently spreading worldwide. Since the number of opioid overdoses is still increasing, it is becoming obvious that current rather un-systematic approaches to tackle this health problem are not effective. This review suggests that fighting the opioid epidemic requires a structured public health approach. Therefore, it is important to consider not only scientific and biomedical perspectives, but societal implications and the lived experience of groups at risk as well.
  • 744
  • 20 Jan 2021
Topic Review
Shift Work Disorder
Shift work disorder (SWD), which is characterized by insomnia and excessive sleepiness related with shift work, is one of the most common health problems in shift workers. Shift work disorder causes insomnia, fatigue, worse work performance, an increased likelihood of accidents, and a poor quality of life. In addition, SWD is associated with decreased productivity and increased economic costs. The correct management of SWD is important to prevent sleep disturbances and maintain work performance in shift workers. To diagnose and evaluate SWD, it is necessary to take detailed medical histories, assess the severity of sleep disturbances, and evaluate shift workers’ sleep using a sleep diary and actigraphy. The work-fitness evaluation should include recommendations on how shift workers can reduce their sleep disturbances and increase work performance, as well as the assessment of work performance. This paper reviews previous research on the evaluation, diagnosis, and management of SWD and summarizes the work-fitness evaluation of SWD.
  • 744
  • 04 Mar 2021
Topic Review
Non-alcoholic Fatty Liver Disease Pathogenesis and Oxidative Stress
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple factors, which may partly explain why it still remains an orphan of adequate therapies. It highlights the interaction between oxidative stress (OS) and disturbed lipid metabolism. Several reactive oxygen species generators, including those produced in the gastrointestinal tract, contribute to the lipotoxic hepatic (and extrahepatic) damage by fatty acids and a great variety of their biologically active metabolites in a “multiple parallel-hit model”. This leads to inflammation and fibrogenesis and contributes to NAFLD progression. The alterations of the oxidant/antioxidant balance affect also metabolism-related organelles, leading to lipid peroxidation, mitochondrial dysfunction, and endoplasmic reticulum stress. This OS-induced damage is at least partially counteracted by the physiological antioxidant response. Therefore, modulation of this defense system emerges as an interesting target to prevent NAFLD development and progression. For instance, probiotics, prebiotics, diet, and fecal microbiota transplantation represent new therapeutic approaches targeting the gut microbiota dysbiosis. The OS and its counter-regulation are under the influence of individual genetic and epigenetic factors as well.
  • 744
  • 14 Feb 2022
Topic Review
Glycolysis and ER Stress
Glycolysis and ER stress have been considered important drivers of pulmonary fibrosis. However, it is not clear whether glycolysis and ER stress are interconnected and if those interconnections regulate the development of pulmonary fibrosis.
  • 744
  • 17 Mar 2022
Topic Review
Aptamer-Based Biosensors for Bisphenol A in Foodstuffs
Bisphenol A (BPA) is a synthetic compound utilized to manufacture plastics for Food Contact Materials (FCMs) or resins for the inside of food containers. Since it was recognized as an Endocrine-Disrupting Chemical (EDC), its implications in pathologies, such as cancer, obesity, diabetes, immune system alterations, and developmental and mental disorders, have been widely documented. Diet is considered the main source of exposure for humans to BPA. Consequently, continuous monitoring of the levels of BPA in foods is necessary to assess the risk associated with its consumption in one’s diet. 
  • 743
  • 29 Apr 2022
Topic Review
Work-Related Stress during Home-Based Remote Work
Remote work takes place outside a designated work location, such as corporate offices, and is often associated with working from home or working (home-based remote work) at a client’s location. In contrast, telework can be conducted remotely as well, but also focuses on the use of personal electronical devices . Ideally, job demands and job resources behave in a dynamic, balanced manner that lead to or maintain employee health. However, when work demands exceed work resources and work resources are inadequate for work demands, an imbalance occurs that leads to WRS over time.
  • 741
  • 31 May 2022
Topic Review
The Social Determinants of Health
The five main areas of social determinants of health (SDOH) are economic stability, healthcare access and quality, education access and quality, social and community context, and the neighborhood and built environment. Each of these domains can be further detailed by specific factors that may go on to affect a patient’s quality of life and health.
  • 741
  • 29 Jan 2023
Topic Review
Two-Step Floating Catchment Area Method
With the continuous aging of society, the demand among elderly citizens for care facilities is increasing. The accessibility of elderly care facilities is a significant indicator for evaluating whether the layout of urban elderly care facilities is reasonable, and research on the spatial accessibility of related facilities has become an important academic issue.
  • 740
  • 27 Sep 2022
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