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Topic Review
Glycyrrhetinic Acid in Liver Cancer Therapy
Liver cancer is one of the most common causes of cancer mortality worldwide. Chemotherapy and radiotherapy are the conventional therapies generally employed in patients with liver tumors. The major issue associated with the administration of chemotherapeutics is their high toxicity and lack of selectivity, leading to systemic toxicity that can be detrimental to the patient’s quality of life. An important approach to the development of original liver-targeted therapeutic products takes advantage of the employment of biologically active ligands able to bind specific receptors on the cytoplasmatic membranes of liver cells. In this perspective, glycyrrhetinic acid (GA), a pentacyclic triterpenoid present in roots and rhizomes of licorice, has been used as a ligand for targeting the liver due to the expression of GA receptors on the sinusoidal surface of mammalian hepatocytes, so it may be employed to modify drug delivery systems (DDSs) and obtain better liver or hepatocyte drug uptake and efficacy.
  • 1.2K
  • 11 Apr 2022
Biography
Robert Döpel
Georg Robert Döpel (3 December 1895 – 2 December 1982) was a Germany experimental nuclear physicist. He was a participant in a group known as the "first Uranverein", which was spawned by a meeting conducted by the Reichserziehungsministerium, in April 1939, to discuss the potential of a sustained nuclear reaction. He worked under Werner Heisenberg at the University of Leipzig, and he conducte
  • 1.2K
  • 29 Nov 2022
Topic Review
Compression of Genomic Sequencing Data
High-throughput sequencing technologies have led to a dramatic decline of genome sequencing costs and to an astonishingly rapid accumulation of genomic data. These technologies are enabling ambitious genome sequencing endeavours, such as the 1000 Genomes Project and 1001 (Arabidopsis thaliana) Genomes Project. The storage and transfer of the tremendous amount of genomic data have become a mainstream problem, motivating the development of high-performance compression tools designed specifically for genomic data. A recent surge of interest in the development of novel algorithms and tools for storing and managing genomic re-sequencing data emphasizes the growing demand for efficient methods for genomic data compression.
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  • 07 Nov 2022
Biography
Rudolf Fleischmann
Rudolf Fleischmann (1 May 1903 – 3 February 2002) was a German experimental nuclear physicist from Erlangen, Bavaria. He worked for Walther Bothe at the Physics Institute of the University of Heidelberg and then at the Institute for Physics of the Kaiser Wilhelm Institute for Medical Research. Through his association with Bothe, he became involved in the German nuclear energy project, also kno
  • 1.2K
  • 12 Dec 2022
Biography
Susanne Hoeber Rudolph
Susanne Hoeber Rudolph (April 3, 1930 – December 23, 2015) was an American author, political thinker and educationist. She was a William Benton Distinguished Service Professor Emerita at the University of Chicago and was actively interested in Politics, Political Economy and Political Sociology of South Asia, State Formation, Max Weber and the Politics of Category and Culture.[1] The Governme
  • 1.2K
  • 29 Dec 2022
Biography
Marilyn E. Jacox
Marilyn Esther Jacox (April 26, 1929 – October 30, 2013) was an American physical chemist. She was a National Institute of Standards and Technology (NIST) Fellow and Scientist Emeritus in the Sensor Science Division.[1] Jacox was born in Utica, New York, the daughter of Grant and Mary Jacox.[2] Jacox graduated summa cum laude with a degree in chemistry in 1951 from Syracuse University, hav
  • 1.2K
  • 28 Nov 2022
Topic Review
Kumarakom
Kumarakom is a popular tourism destination located near the city of Kottayam (10 kilometres (6 mi)), in Kerala, India , famous for its backwater tourism. It is set in the backdrop of the Vembanad Lake, the largest lake in the state of Kerala.
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  • 02 Dec 2022
Biography
Amos Bairoch
Amos Bairoch (born 22 November 1957) is a Swiss bioinformatician[1][2][3] and Professor of Bioinformatics at the Department of Human Protein Sciences of the University of Geneva where he leads the CALIPHO group[4] at the Swiss Institute of Bioinformatics (SIB) combining bioinformatics, curation, and experimental efforts to functionally characterize human proteins.[5] His father was the economic
  • 1.2K
  • 06 Dec 2022
Biography
Ian Budge
Ian Budge (born October 21, 1936) is a political scientist who has pioneered the use of quantitative methods in studying party democracy across countries. Currently Emeritus Professor of the Department of Government, University of Essex he has been Professor at the European University Institute, Florence (1982-5).[1] and visiting professor at various institutions in five other countries.[2][3] H
  • 1.2K
  • 12 Dec 2022
Biography
I. Bernard Cohen
Ierome Bernard Cohen (1 March 1914 – 20 June 2003) was the Victor S. Thomas Professor of the history of science at Harvard University and the author of many books on the history of science and, in particular, Isaac Newton. Cohen was the first American to receive a PhD in history of science, was a Harvard undergraduate ('37) and then a PhD student and protégé of George Sarton who was the fou
  • 1.2K
  • 26 Dec 2022
Biography
Gioacchino Failla
Gioacchino Failla (19 July 1891 – 15 December 1961) was an Italian-born American physicist. A pioneer in both biophysics and radiobiology, he was particularly noted for his work on the role of radiation as a cause of cancer and genetic mutation. He was born in Castelbuono in the Province of Palermo and emigrated with his family to the United States in 1906. After his retirement from Columbia U
  • 1.2K
  • 30 Nov 2022
Biography
Homer Neal
Homer Alfred Neal (June 13, 1942 – May 23, 2018[1]) was an African-American[2] particle physicist and a distinguished professor at the University of Michigan.[3] Neal was President of the American Physical Society in 2016.[4] He was also a board member of Ford Motor Company, a council member of the National Museum of African American History and Culture, and a director of the Richard Lounsbery
  • 1.2K
  • 29 Dec 2022
Topic Review
Vitamin C in Various Diets
Recent research studies have shown that vitamin C (ascorbic acid) may affect bone mineral density and that a deficiency of ascorbic acid leads to the development of osteoporosis. Patients suffering from an inflammatory bowel disease are at a risk of low bone mineral density. It is vital to notice that patients with Crohn’s disease and ulcerative colitis also are at risk of vitamin C deficiency which is due to factors such as reduced consumption of fresh vegetables and fruits, i.e., the main sources of ascorbic acid. Additionally, some patients follow diets which may provide an insufficient amount of vitamin C. The entry contains information about vitamin C content and impact of various diets- Mediterranean diet, vegetarian diets, low-carbohydrates diets and low-FODMAP diet- on bone mineral density and inflammatory bowel disease course. 
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  • 08 Sep 2020
Biography
Rachel Sibande
Rachel Chimwemwe Sibande (born January 9, 1986) is a Malawian technology expert, computer scientist, STEM educator, social entrepreneur and innovator. She is the Founder and Director of Malawi`s First innovation Hub and incubator for emerging start-ups, entrepreneurs and innovators, mHub. Rachel is an entrepreneur in the technology and energy space. Apart from the Hub, Rachel is Chairperson at G
  • 1.2K
  • 27 Dec 2022
Topic Review
Harvestman Anatomy
Harvestmen (Opiliones) are an order of arachnids and share many common characteristics with other arachnids. However, several differences separate harvestmen from other arachnid orders such as spiders. The bodies of opliones are divided into two tagmata (arthropod body regions): the abdomen (opisthosoma) and the cephalothorax (prosoma). Unlike spiders, the juncture between the abdomen and cephalothorax is often poorly defined. Harvestmen have chelicerae, pedipalps and four pairs of legs. Most harvestmen have two eyes, although there are eyeless species.
  • 1.2K
  • 27 Oct 2022
Topic Review
Lagosuchidae
Lagosuchus is an extinct genus of avemetatarsalian archosaur from the Late Triassic of Argentina . The type species of Lagosuchus, Lagosuchus talampayensis, is based on a small partial skeleton recovered from the early Carnian-age Chañares Formation. The holotype skeleton of L. talampayensis is fairly fragmentary, but it does possess some traits suggesting that Lagosuchus was a probable dinosauriform, closely related to dinosaurs. A second potential species of Lagosuchus, L. lilloensis, is based on an assortment of slightly larger and more well-preserved fossils. These larger specimens have been considered much more diagnostic and informative than the original small L. talampayensis skeleton. As a result, some paleontologists have placed the larger specimens into a new genus, Marasuchus. Marasuchus is generally considered one of the more complete early dinosauriforms, useful for estimating ancestral traits for the origin of dinosaurs. This would also render Lagosuchus a nomen dubium, simply a name referring to a fossil which is too fragmentary to have a formal genus. However, other paleontologists support the argument that Lagosuchus is a valid genus, and that Marasuchus is a junior synonym of it.
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  • 12 Dec 2022
Topic Review
Microenvironments of Parvalbumin-Expressing GABAergic Interneurons
Data suggest that pathological disturbance of the population of fast-spiking, parvalbumin-expressing GABAergic inhibitory interneurons occur in at least some clinical presentations, which leads to disruption of the synchronous oscillatory output of assemblies of pyramidal neurons. Increased expression of the GluN2A NMDA receptor subunit on parvalbumin-expressing interneurons is linked to functional maturation of both these neurons and the perineuronal nets that surround them. Disruption of GluN2A expression shows increased susceptibility to oxidative stress, reflected in redox dysregulation and delayed maturation of PNNs.
  • 1.2K
  • 10 Sep 2021
Biography
Peter Kalmus
Peter Ignaz Paul Kalmus OBE FInstP (born 25 January 1933), is a British particle physicist, and emeritus professor of physics at Queen Mary, University of London.[1] Kalmus was born in Prague on 25 January 1933, and moved to Britain with his parents and younger brother George Kalmus in 1939. His sister Elsa was born in 1945. The family became British citizens in 1946. Kalmus went to school
  • 1.2K
  • 29 Dec 2022
Biography
Robert L. Forward
Robert Lull Forward (August 15, 1932 – September 21, 2002) was an American physicist and science fiction writer.[1] His literary work was noted for its scientific credibility and use of ideas developed from his career as an aerospace engineer. He also made important contributions to gravitational wave detection research.[2] Forward earned his doctorate from the University of Maryland in 196
  • 1.2K
  • 12 Dec 2022
Topic Review
Phasing-Out of Animal Testing in Cosmetics
Almost a decade after the stipulated deadline in the 7th amendment to the EU Cosmetics Directive, which bans the marketing of animal-tested cosmetics in the EU from 2013, animal experimentation for cosmetic-related purposes remains a topic of animated debate.
  • 1.2K
  • 20 Sep 2022
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