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Topic Review
Microglia in Immunological Dysfunction in Schizophrenia
Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Microglia are the resident brain innate immune cells that have been implicated in host defense against neurotropic pathogens, brain development, and neurodegenerative disorders.
  • 393
  • 23 Aug 2023
Topic Review
GABA Positive Allosteric Modulator (GPAM)—Brexanolone
Brexanolone is a positive allosteric modulator (PAM) of gamma amino butyric acid-type A (GABA-A) receptors and is the first FDA-approved drug to manage postpartum depression (PPD).
  • 359
  • 25 May 2023
Topic Review
Evening Chronotype and Suicide
A chronotype is generally defined as the variability of the phase angle of entrainment, while the latter reflects the relationship between the timing of a certain rhythm (e.g., the sleep–wake cycle) and the timing of an external temporal cue. Individuals can be placed on a spectrum from “morning types” (M types) to “evening types” (E types). E-chronotype has been proposed as a transdiagnostic risk factor for psychiatric conditions, and it has been associated with psychopathological dimensions. Eveningness seems to be correlated with both suicidal ideation (SI) and suicidal behavior (SB) through several possible mediating factors. Immunological alterations have also been linked to later chronotypes and SI/SB. 
  • 218
  • 04 Jan 2024
Topic Review
Gut Microbiome Changes in Anorexia Nervosa
Anorexia nervosa (AN) remains a challenging condition in psychiatric management and its pathogenesis is not yet fully understood. An imbalance in the gut microbiota composition may contribute to its pathophysiology. There is an imbalance in gut microbiota composition leads to reduced short-chain fatty acids, contributing to a proinflammatory state in AN, which is also common in other psychiatric comorbidities. Microbial changes may also contribute to the semistarvation state through endocrine changes and altered energy utilization.
  • 174
  • 28 Feb 2024
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