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Topic Review
Radiolabeled Peptoids and Peptoid/Peptide Hybrids for Cancer-Targeted Imaging
Peptoids (N-substituted glycine oligomers) are a relatively new class of peptidomimetics, being highly versatile and capable of mimicking the architectures and the activities of the peptides but with a marked resistance to proteases and a propensity to cross the cellular membranes over the peptides themselves. For these properties, they have gained an ever greater interest in applications in bioengineering and biomedical fields.
  • 545
  • 30 Nov 2023
Topic Review
The Mammalian Thioredoxin Reductase Probes
The cardinal component of the thioredoxin system, mammalian thioredoxin reductase (TrxR) plays a vital role in supporting various physiological functions; however, its malfunction, disrupting redox balance, is intimately associated with the pathogenesis of multiple diseases. Fluorescent probes offer several advantages for in situ imaging and the quantification of biological targets, such as non-destructiveness, real-time analysis, and high spatiotemporal resolution. These benefits facilitate the transition from a poise to a flux understanding of cellular targets, further advancing scientific studies in related fields. The TrxR fluorescent probes have contributed significantly to the investigation of TrxR’s biological functions and have been valuable tools in TrxR-related research.
  • 521
  • 24 Aug 2023
Topic Review
Modeling for CADD with Small Molecules
COVID-19 has claimed around 7 million lives (from December 2019–November 2023) worldwide and continues to impact global health. SARS-CoV-2, the virus causing COVID-19 disease, is characterized by a high rate of mutations, which contributes to its rapid spread, virulence, and vaccine escape. While several vaccines have been produced to minimize the severity of the coronavirus, and diverse treatment regimens have been approved by the US FDA under Emergency Use Authorization (EUA), SARS-CoV-2 viral mutations continue to derail the efforts of scientists as the emerging variants evade the recommended therapies. Nonetheless, diverse computational models exist that offer an opportunity for the swift development of new drugs or the repurposing of old drugs. 
  • 489
  • 10 Jan 2024
Topic Review Peer Reviewed
Challenges and Recommendations on Digital Health Sources in Pediatric Chronic Suppurative Lung Diseases
In the context of digitalizing healthcare systems, digital health sources (DHSs) aim to enhance the efficiency, accessibility, and quality of healthcare services by leveraging technology. Multiple types of DHSs are increasingly established in healthcare, providing direct and wide communication between pediatric patients, parents, and healthcare professionals. Therefore, they are considered promising key tools to improve pediatric disease monitoring and management. At the same time, DHSs have been associated with several issues and risks, such as those related to data sharing, privacy, and the cultural readiness of the users. Yet, discussions in the literature have mostly focused on technical considerations and a user-friendly design. In contrast, the contribution of DHSs to treatment engagement in pediatric populations and data sharing has only partially been discussed. On this basis, we provide an overview of the available digital health technologies and their application in the pediatric population with chronic suppurative lung diseases; we describe the effectiveness in health-related outcomes, discuss possible challenges, and propose some recommendations that may overcome barriers in their everyday use.
  • 344
  • 06 Jan 2025
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