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Topic Review
Computer-Aided Diagnosis Using Gastrointestinal Endoscopy
Computer-aided diagnosis (CAD) system based on deep learning to assist doctors in diagnosis is of great significance, because diagnosing lesions in the stomach, intestines, and esophagus is laborious for doctors. In addition, misdiagnoses can occur based on a subjective judgment.
  • 1.1K
  • 22 Apr 2021
Topic Review
Immunotherapeutic Treatments in Multiple Myeloma
Immunosuppression is a common feature of multiple myeloma (MM) patients and has been associated with disease evolution from its precursor stages. MM cells promote immunosuppressive effects due to both the secretion of soluble factors, which inhibit the function of immune effector cells, and the recruitment of immunosuppressive populations. Alterations in the expression of surface molecules are also responsible for immunosuppression.
  • 1.1K
  • 23 Jun 2021
Topic Review
Elderly Tinnitus and Neuropsychological Dysfunction
Tinnitus is a common and disabling symptom often associated with hearing loss. While clinical practice frequently shows that a certain degree of psychological discomfort often characterizes tinnitus suffers, it has been recently suggested in adults as a determining factor for cognitive decline affecting attention and memory domains. 
  • 1.1K
  • 18 Jun 2021
Topic Review
Surface-Water Quality Monitoring
The monitoring of surface-water quality followed by water-quality modeling and analysis are essential for generating effective strategies in surface-water-resource management. However, worldwide, particularly in developing countries, water-quality studies are limited due to the lack of a complete and reliable dataset of surface-water-quality variables.
  • 1.1K
  • 06 Jul 2021
Topic Review
Enhancing Plants Fungal Disease Resistance
Fungal diseases pose a major threat to ornamental plants, with an increasing percentage of pathogen-driven host losses. In ornamental plants, management of the majority of fungal diseases primarily depends upon chemical control methods that are often non-specific. Host basal resistance, which is deficient in many ornamental plants, plays a key role in combating diseases. Despite their economic importance, conventional and molecular breeding approaches in ornamental plants to facilitate disease resistance are lagging, and this is predominantly due to their complex genomes, limited availability of gene pools, and degree of heterozygosity.
  • 1.1K
  • 12 Aug 2021
Topic Review
Australian Tick Vaccines
Australia has led the world in the development of anti-tick vaccines. The first anti-cattle tick recombinant vaccine was developed by researchers from Australia’s National Science agency—the Commonwealth Scientific and Industrial Research Organisation (CSIRO) in the late 1980s. Attempts to develop a canine anti-paralysis tick vaccine were also reported in the 1980s in Australia through research, also originally led by CSIRO.
  • 1.1K
  • 27 Oct 2021
Topic Review
Atrial Fibrillation Pathogenesis
Electrical remodeling lies on impaired calcium handling, enhanced inwardly rectifying potassium currents, and gap junction perturbations. In addition, a wide array of profibrotic stimuli activates fibroblast to an increased extracellular matrix turnover via various intermediaries. Concomitant dysregulation of the autonomic nervous system and the humoral function of increased epicardial adipose tissue (EAT) are established mediators in the pathophysiology of AF. Local atrial lymphomononuclear cells infiltrate and increased inflammasome activity accelerate and perpetuate arrhythmia substrate. Finally, impaired intracellular protein metabolism, excessive oxidative stress, and mitochondrial dysfunction deplete atrial cardiomyocyte ATP and promote arrhythmogenesis. 
  • 1.1K
  • 09 Oct 2021
Topic Review
Dietary Antioxidants in Age-Related Macular Degeneration and Glaucoma
Age-related macular degeneration (AMD) and glaucoma are ophthalmic neurodegenerative diseases responsible for irreversible vision loss in the world population. Only a few therapies can be used to slow down the progression of these diseases and there are no available treatment strategies for reversing the degeneration of the neural retina. In AMD, the pathological process causes the malfunction and damage of the retinal pigmented epithelium and photoreceptors in the macula. In glaucoma, damage of the retinal ganglion cells and their axons is observed and treatment strategies are limited to intraocular pressure lowering. Therefore, other prophylactic and/or therapeutic methods are needed. Oxidative stress is involved in the neurodegenerative process accompanying both AMD and glaucoma; therefore, the use of antioxidant agents would clearly be beneficial, which is supported by the decreased prevalence and progression of AMD in patients adherent to a diet naturally rich in antioxidants.
  • 1.1K
  • 11 Nov 2021
Topic Review
Molecular Techniques for Schistosomiasis
Diagnostic tools play a pivotal role in warfare against schistosomiasis but must adapt to the endemic status and objectives of activities. With the decrease of prevalence and infection intensity of schistosomiasis in human beings and livestock, optimal methodologies with high sensitivity and absolute specificity are needed for the detection of asymptomatic cases or light infections, as well as disease surveillance to verify elimination. In comparison with the parasitological methods with relatively low sensitivity and serological techniques lacking specificity, which both had been widely used in previous control stages, the molecular detection methods based on the amplification of promising genes of the schistosome genome may pick up the baton to assist the eventual aim of elimination.
  • 1.1K
  • 29 Mar 2022
Topic Review
Outlook on Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is characterized as a disorder of the heart muscle. It is distinguished by the widening/dilation of the left ventricle of the heart with left ventricular or biventricular systolic dysfunction. Contractile functioning of the left ventricle is highly compromised due to dilation. However, in some cases of DCM, the right ventricle is also dilated. Dilated cardiomyopathy (DCM) remains an enigmatic cardiovascular disease (CVD) condition characterized by contractile dysfunction of the myocardium due to dilation of the ventricles. DCM is one of the major forms of CVD contributing to heart failure. Dilation of the left or both ventricles with systolic dysfunction, not explained by known causes, is a hallmark of DCM. Progression of DCM leads to heart failure. Genetic and various other factors greatly contribute to the development of DCM, but the etiology has still remained elusive in a large number of cases. 
  • 1.1K
  • 15 Jun 2022
Topic Review
Distributed Denial-of-Service Attacks
With the rapid advancement and transformation of technology, information and communication technologies (ICT), in particular, has attracted everyone’s attention. The attackers took advantage of this and can be caused serious problems, such as malware attacks, ransomware, SQL injection attack and so on. One of the dominant attacks, known as distributed denial-of-service (DDoS), has been observed as the main reason for information hacking.
  • 1.1K
  • 21 Sep 2022
Topic Review
Scriptural Reasoning
Scriptural Reasoning ("SR") is one type of interdisciplinary, interfaith scriptural reading. It is an evolving practice in which Christians, Jews, Muslims, and sometimes members of other faiths, meet to study their sacred scriptures together, and to explore the ways in which such study can help them understand and respond to particular contemporary issues. Originally developed by theologians and religious philosophers as a means of fostering post-critical and postliberal corrections to patterns of modern reasoning, it has now spread beyond academic circles. The claims made by some of Scriptural Reasoning's founder practitioners that they have requisite knowledge of ancient traditions of Islamic, Jewish and Christian exegesis and also the authority to apply such traditional wisdom to correct modernist binarist or fundamentalist readings, have been challenged by theologians of different faiths. The practical outworking of some Scriptural Reasoning projects have been criticised for alleged lack of parity between participating religions, and alleged instrumentalising of sacred texts for political and financial purposes.
  • 1.1K
  • 04 Oct 2022
Topic Review
Range Encoding
Range encoding is an entropy coding method defined by G. Nigel N. Martin in a 1979 paper, which effectively rediscovered the FIFO arithmetic code first introduced by Richard Clark Pasco in 1976. Given a stream of symbols and their probabilities, a range coder produces a space-efficient stream of bits to represent these symbols and, given the stream and the probabilities, a range decoder reverses the process. Range coding is very similar to arithmetic encoding, except that encoding is done with digits in any base, instead of with bits, and so it is faster when using larger bases (e.g. a byte) at small cost in compression efficiency. After the expiration of the first (1978) arithmetic coding patent, range encoding appeared to clearly be free of patent encumbrances. This particularly drove interest in the technique in the open source community. Since that time, patents on various well-known arithmetic coding techniques have also expired.
  • 1.1K
  • 14 Oct 2022
Topic Review
More Hall Annex
The More Hall Annex, formerly the Nuclear Reactor Building, was a building on the campus of the University of Washington (UW) in Seattle, Washington, United States, that once housed a functional nuclear research reactor. It was inaugurated in 1961 and shut down in 1988, operating at a peak of 100 kilowatts thermal (kWt), and was officially decommissioned in 2007. The reactor was housed in a reinforced concrete building designed in the Brutalist architectural style by UW faculty members. They designed the reactor room with large windows that allowed observation from the outside, in an attempt to demonstrate the safety of nuclear energy. The Nuclear Reactor Building was added to the National Register of Historic Places in 2009, after a campaign led by an architecture student in response to the proposed demolition of the building. A later demolition plan prompted a lawsuit from preservation groups, which ended with a court ruling exempting the building from the city's landmarks-preservation ordinance. While this decision was eventually overturned, the university demolished the building in July 2016 and replaced it with a new computer science building that opened in February 2019.
  • 1.1K
  • 27 Oct 2022
Topic Review
Packard Bell Statesman
The Packard Bell Statesman was an economy line of notebook computers introduced in 1993 by Packard Bell. They were slower in performance and lacked features compared to most competitor products, but they were lower in price. It was created in a collaboration between Packard Bell and Zenith Data Systems. The Statesman series was essentially a rebrand of Zenith Data Systems Z-Star 433 series, with the only notable difference of the logo in the middle and text on the front bezel.
  • 1.1K
  • 27 Oct 2022
Topic Review
Membrane Vesicles Derived from Gut Microbiota
Multidrug-resistant (MDR) superbugs can breach the blood–brain barrier (BBB), leading to a continuous barrage of pro-inflammatory modulators and induction of severe infection-related pathologies, including meningitis and brain abscess. Both broad-spectrum or species-specific antibiotics (β-lactamase inhibitors, polymyxins, vancomycin, meropenem, plazomicin, and sarecycline) and biocompatible poly (lactic-co-glycolic acid) (PLGA) nanoparticles have been used to treat these infections. However, new therapeutic platforms with a broad impact that do not exert off-target deleterious effects are needed. Membrane vesicles or extracellular vesicles (EVs) are lipid bilayer-enclosed particles with therapeutic potential owing to their ability to circumvent BBB constraints. Bacteria-derived EVs (bEVs) from gut microbiota are efficient transporters that can penetrate the central nervous system. In fact, bEVs can be remodeled via surface modification and CRISPR/Cas editing and, thus, represent a novel platform for conferring protection against infections breaching the BBB.
  • 1.1K
  • 09 Dec 2022
Topic Review
General Synthesis Methods of Poly (ε-caprolactone)-Based Graft Copolymers
Synthetic biopolymers are attractive alternatives to biobased polymers, especially because they rarely induce an immune response in a living organism. Poly ε-caprolactone (PCL) is a well-known synthetic aliphatic polyester universally used for many applications, including biomedical and environmental ones.  To expand the range of applications for PCL, researchers have investigated the possibility of grafting polymer chains onto the PCL backbone. As the PCL backbone is not functionalized, it must be first functionalized in order to be able to graft reactive groups onto the PCL chain. These reactive groups will then allow the grafting of new reagents and especially new polymer chains. Grafting of polymer chains is mainly carried out by “grafting from” or “grafting onto” methods.
  • 1.1K
  • 29 Nov 2022
Topic Review
Cytokines as Selected Biomarkers of Depression
Depression is one of the leading mental illnesses worldwide and lowers the quality of life of many. According to WHO, about 5% of the worldwide population suffers from depression. Studies report a staggering global prevalence of 27.6%, and it is rising. Professionally, depression belonging to affective disorders is a psychiatric illness, and the category of major depressive disorder (MDD) comprises various diagnoses related to persistent and disruptive mood disorders. Due to this fact, it is imperative to find a way to assess depression quantitatively using a specific biomarker or a panel of biomarkers that would be able to reflect the patients’ state and the effects of therapy. Cytokines, hormones, oxidative stress markers, and neuropeptides are studied in association with depression. 
  • 1.1K
  • 31 Jan 2023
Topic Review
The Sensing Techniques for Formaldehyde Detection
Formaldehyde has been regarded as a common indoor pollutant and does great harm to human health, which has caused the relevant departments to pay attention to its accurate detection. Spectrophotometry, gas chromatography, liquid chromatography, and other methods have been proposed for formaldehyde detection. Among them, the gas sensor is especially suitable for common gaseous formaldehyde detection with the fastest response speed and the highest sensitivity. 
  • 1.1K
  • 28 Feb 2023
Topic Review
Damping Effect of Buckling-Restrained Braces
Modern cities are becoming more and more dependent on transportation with the rapid growth of the population and the development of the economy. As a traffic lifeline, once a bridge is damaged in an earthquake, traffic will be hindered, and restoring and rebuilding the bridge will take a long time, which will affect the daily life of drivers and locals. Therefore, bridge seismic problems cannot be ignored. One of the most widely used damping methods used to mitigate the seismic responses of bridges in recent years is the application of buckling-restrained braces (BRBs). Due to their stable mechanical properties, simple construction, and simple designs, BRBs are effective seismic dampers that are gradually being applied in the study of seismic bridges to improve their seismic capacities. With the development of engineering technology, the structure of BRBs is constantly being updated, and experimental and theoretical research on them has gradually attracted increasing attention.
  • 1.1K
  • 07 Apr 2023
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