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Topic Review
Mudflation
Mudflation, from MUD and inflation, is an economic issue that exists in massively multiplayer online games. Mudflation occurs when future additions to (or even just continued operation of) a game causes previously acquired resources to decline in value. This can take many forms and have many causes, including new items introduced by an expansion pack, fundamental imbalances in the in-game economy, or even spread of information that allows a previously rare resource to be acquired more easily.
  • 1.1K
  • 25 Oct 2022
Topic Review
Gut Microsex/Genderome, Immunity and Stress in the Sexes
Sex has been universally acknowledged as a confounding factor in every type of biological study, while there are strong sex differences in morbidity along the lifespan. Humans have almost identical genomes (99.2%), yet minor variance in their DNA produces remarkable phenotypic diversity across the human population. On the other hand, metagenomic analysis of the human microbiome is more variable, depending on the sex, lifestyle, geography, and age of individuals under study. Immune responses in humans also exhibit variations, with an especially striking sexual dimorphism, which is at play in several other physiologic processes. Sex steroids have noticeable effects on the composition of the human microbiome along the lifespan, accompanied by parallel changes in immunity and the stress response. Gut microsex/genderome, a recently coined term, defines the sexually dimorphic gut microbiome. Apart from the sex steroids, the stress hormones are also at play in the proliferation of microbes.
  • 1.1K
  • 10 Nov 2022
Topic Review
TEVs-Mediated Communication between Tumor and Immune Cells
Tumor cell-derived extracellular vesicles (TEVs) are an important means of tumor communication with, and manipulation of, the patient’s physiology. TEVs influence the local tumor environment as well as the systemic conditions of the patient.
  • 1.1K
  • 28 Dec 2022
Topic Review
Microneedles in Cancer Therapy and Diagnosis
The tumor is an uncontrolled growth of tissue that can be localized (benign) or possesses the capability of metastasis (malignant). The conventional methods of tumor diagnosis, such as acupuncture, endoscopy, and histopathology, and treatment methods, such as injections, chemotherapy, surgery, and radiotherapy, are invasive, expensive, and pose severe safety and management issues for the patients. Microneedle technology is minimally invasive, self-administrable, bypasses the first-pass effect, effectively delivers chemotherapeutics and drugs at low doses, and provides drug diffusion into the tumor areas, thus, overcoming the drawbacks of conventional delivery systems.
  • 1.1K
  • 12 Jan 2023
Topic Review
Green Synthesis of Carbon Nanoparticles from Biomass
Carbon nanoparticles (CNPs) have demonstrated utility in a wide range of biological applications such as imaging, sensing and as surface-coatings. Biomass waste can be derived from either plant or animal matter as a result of processing higher-value materials, for instance leaves from trees as by product from processed wood or paper production. Biomass is abundant: trees, agriculture crops, energy crops, fruits, vegetation, wood, aquatic plants and algae, general municipal waste and animal waste.
  • 1.1K
  • 31 Jan 2023
Topic Review
Hyperbaric Oxygen Therapy in Children
The coronavirus disease (COVID-19) epidemic is a public health emergency of international concern. It was believed that SARS-CoV-2 virus was much less likely affect children. Statistics show that children account for 2–13% of all COVID-19 patients in individual countries. In the youngest population, acute respiratory failure is not as serious a problem as complications after COVID-19, mainly pediatric inflammatory multisystem syndrome (PIMS, MIS-C). Thirteen publications that quantitatively and qualitatively described the efficacy of HBOT application in the treatment of pediatric diseases were eligible among the studies; those relating to the use of hyperbaric oxygen therapy (HBOT) in the treatment of children with COVID-19 and its complications were not found. The bibliographic review showed that hyperbaric oxygen therapy can be used in the treatment of children after carbon monoxide poisoning, with soft tissue necrosis, bone necrosis, after burns, or after skin transplant. No evidence supported by research has been found in scientific journals on the effectiveness of the use of hyperbaric oxygen therapy in children with a history of COVID-19 infection. Research data are needed to develop evidence-driven strategies with regard to the use of HBOT therapy in the treatment of children and to reduce the number of pediatric patients suffering because of complications after COVID-19.
  • 1.1K
  • 02 Feb 2023
Topic Review
Sleep Disturbances in Parkinson’s Disease
Parkinson’s disease (PD) is a common multidimensional neurological disorder characterized by motor and non-motor features and is more prevalent in the elderly. Sleep disorders and cognitive disturbances are also significant characteristics of PD. Sleep is an important physiological process for normal human cognition and physical functioning. Sleep deprivation negatively impacts human physical, mental, and behavioral functions. Sleep disturbances include problems falling asleep, disturbances occurring during sleep, abnormal movements during sleep, insufficient sleep, and excessive sleep. The most recognizable and known sleep disorders, such as rapid-eye-movement behavior disorder (RBD), insomnia, excessive daytime sleepiness (EDS), restless legs syndrome (RLS), sleep-related breathing disorders (SRBDs), and circadian-rhythm-related sleep–wake disorders (CRSWDs), have been associated with PD. 
  • 1.1K
  • 24 Aug 2023
Topic Review
Application of Infrared and Visible Image Fusion
Infrared and visible light image fusion combines infrared and visible light images to provide a more comprehensive image with more features from two photos by extracting the main information from each image and fusing it together.
  • 1.1K
  • 16 Oct 2023
Topic Review
Construction Progress Monitoring
In the architecture, engineering and construction industry, site management during construction is a key phase. Scheduling activities and monitoring their progress allow any deviations from the schedule to be identified so that timely action can be taken. Until now, the monitoring phase has mainly been characterised by inspections in which the construction site manager manually collects data and produces a summary report. This proves to be a time-consuming process and is prone to errors.
  • 1.1K
  • 24 Oct 2023
Topic Review
PET Imaging
PET imaging is being increasingly used to supplement MRI in the clinical management of brain tumors. The main radiotracers implemented in clinical practice include [18F]FDG, radiolabeled amino acids ([11C]MET, [18F]FDOPA, [18F]FET) and [68Ga]Ga-DOTA-SSTR, targeting glucose metabolism, L-amino-acid transport and somatostatin receptors expression, respectively. 
  • 1.1K
  • 17 Feb 2022
Topic Review
Remote Ischemic Preconditioning
Autophagy is a cellular process by which mammalian cells degrade and assist in recycling damaged organelles and proteins. This study aimed to ascertain the role of autophagy in RIPC-induced cardioprotection. Sprague Dawley rats were subjected to RIPC at the hindlimb followed by 30 min transient blockade of the left coronary artery to simulate I/R injury. Hindlimb muscle and the heart were excised 24 h post reperfusion. RIPC prior to I/R upregulated autophagy in the rat heart at 24 h post reperfusion. In vitro, autophagy inhibition or stimulation prior to RIPC respectively, either ameliorated or stimulated the cardioprotective effect, measured as improved cell viability to mimic the preconditioning effect. Recombinant IL-6 treatment prior to I/R increased in vitro autophagy in a dose dependent manner activating the JAK-STAT pathway without affecting the other kinase pathways such as p38 MAPK, and GSK-3β pathways. Prior to I/R, in vitro inhibition of the JAK-STAT pathway reduced autophagy upregulation despite recombinant IL-6 pre-treatment. Autophagy is an essential component of RIPC-induced cardioprotection that may upregulate autophagy through an IL-6/JAK-STAT dependent mechanism, thus identifying a potentially new therapeutic option for the treatment of ischemic heart disease.
  • 1.1K
  • 29 Oct 2020
Topic Review
Analysing Hucul Horses by AI
       The neural classification system in form of a multi-layered artificial neural network suggested in this paper was implemented in the programming environment MATLAB. MATLAB is a useful tool focused mainly on scientific and technical calculations. It boasts of a wide spectrum of software solutions/libraries, the so-called Toolboxes that can be used, for example to create and optimize neural networks. It is fully compatible with other programming environments.  Matlab is a tool for rapid prototyping that enables a wide range of learning algorithms, the selection of optimal neural network architecture, the selection of the most efficient neuron activation functions as well as optimal learning parameters.          The design of the network is of key significance both for the learning process, and the quality of its operation in later stages. The set of input data, purpose, and results do have significant impact on the they configuration.  A key assumption is taking cognizance of factual links between the set of explanatory variables (input) and the output.        The artificial neural networks enable the capture of relationships and dependencies between the data in circumstances where the application of traditional analytical methods would not have yielded satisfactory solutions.         The use of ANN enables objective assessments of individual animals by taking into account only factors essential for determining horses’ performance and breeding values.         Preliminary results of the application of artificial neural networks in predicting the utility value of Hucul horses, relying on a specific set of features seem rather promising.        It offers potential possibilities of evaluation, relying on available information about the animals.
  • 1.1K
  • 13 Oct 2020
Topic Review
Community-Acquired Antimicrobial Resistant Enterobacteriaceae
Antimicrobial resistance (AMR) is an issue of increasing importance worldwide. Community-acquired antimicrobial resistant Enterobacteriaceae (CA-ARE) are of particular concern because of the risks they pose to human health and the variety of drivers that promote their spread. Community-acquired refers to the mechanism of AMR spread, which is in the community rather than clinical settings. Enterobacteriaceae are a family of Gram-negative bacteria. Antimicrobial misuse in clinical settings and food animal production is amplified by environmental contamination and persistence in the community, resulting in the spread of CA-ARE. Because the factors contributing to the proliferation of CA-ARE are multifaceted and interconnected, it is critical to use a One Health framework, which focuses on the interfaces between humans, animals, and the environment, to address this issue. This approach will help future collaborations between stakeholders in the animal, environmental, and human health sectors incorporate multidisciplinary aims to be more successful in mitigating the spread of CA-ARE and antimicrobial resistance in general. 
  • 1.1K
  • 19 Nov 2020
Topic Review
Supercritical Fluids for the Encapsulation
Encapsulation based on supercritical fluids has shown several advantages as green technology for the production of functional ingredients with enhanced stability and tailored protection from environmental factors. Thanks to the inherent absence of organic solvent, the low temperature of the process to reach the supercritical state and the capacity to dissolve lipid soluble bioactives, it allows obtaining functional ingredient easily designed to tailor the controlled release of the bioactive, or to reach specific levels of taste, odor and color. The present entry aims to highlight the pros and cons of the encapsulation techniques based on supercritical fluids giving emphasis to their innovative aspects that could be of interest to the food industry.
  • 1.1K
  • 25 Dec 2020
Topic Review
Rigid Spine Muscular Dystrophy
Rigid spine muscular dystrophy (RSMD) is a form of congenital muscular dystrophy. Disorders in this group cause muscle weakness and wasting (atrophy) beginning very early in life. In particular, RSMD involves weakness of the muscles of the torso and neck (axial muscles). Other characteristic features include spine stiffness and serious breathing problems
  • 1.1K
  • 24 Dec 2020
Topic Review
Friedreich’s Ataxia
Friedreich’s ataxia (FRDA, MIM 229300) is an autosomal recessive neurodegenerative disease and it is the most prevalent hereditary ataxia in the Caucasian population, with a prevalence of around 2–4 in 100,000 individuals.  FRDA is classically characterized by progressive gait ataxia, dysarthria, dysphagia, oculomotor dysfunction, loss of deep tendon reflexes, signs of pyramidal tract involvement, scoliosis, visual loss, and poor hearing, and in some cases, cardiomyopathy, diabetes mellitus. FRDA is caused by an unstable GAA expansion located in intron 1 of the FXN gene (9q21.11) that encodes for frataxin (Fxn). The function of Fxn is not completely known, but the most widely accepted theory is that it plays a role in the biogenesis of iron-sulfur clusters required for the correct function of several proteins.
  • 1.1K
  • 07 Jan 2021
Topic Review
TRPV4 Ion Channel
The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modulated by a range of post-translational modifications, the majority of which we are only just beginning to understand. Not surprisingly, a great number of physiological roles have emerged for TRPV4, as have various disease states that are attributable to the absence, or abnormal functioning, of this ion channel. This review will highlight structural features of TRPV4, endogenous and exogenous activators of the channel, and discuss the reported roles of TRPV4 in health and disease.
  • 1.1K
  • 01 Feb 2021
Topic Review
Autoimmunity
Under normal circumstances, the immune system only reacts to foreign body antigens other than itself, but when it causes an immune response to its own constituents for some reason, it is called Autoimmunity. 
  • 1.1K
  • 21 Jul 2021
Topic Review
Prior Work on Sustainable Knowledge Sharing Practices
Creating the appropriate environment to share knowledge freely among members is vital to the long-term success of organizations. We argue that organizational factors can enable the conditions that promote knowledge sharing for sustainable competitive advantage. An analysis of the extant literature reveals several organizational factors that must be in place to enable successful knowledge sharing. The literature provides empirical evidence to suggest that trust, communication, reward systems and leadership may be particularly important and so are discussed in more detail below. While it is acknowledged that these categories are by no means exhaustive or indeed mutually exclusive, they are however clearly important to enable successful knowledge sharing in practice and have implications for sustainable management and so deserve further scrutiny.
  • 1.1K
  • 25 Nov 2021
Topic Review
Cardiomyopathies: An Overview
Cardiomyopathies are a heterogeneous group of pathologies characterized by structural and functional alterations of the heart. 
  • 1.1K
  • 30 Nov 2021
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