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Topic Review
Manual Therapy in Cervical/Lumbar Radiculopathy
A comprehensive literature review was conducted using PubMed and Web of Science databases up to April 2020. The following inclusion criteria were used: (1) presence of radiculopathy; (2) treatment defined as manual therapy (i.e., traction, manipulation, mobilization); and (3) publication defined as a Randomized Controlled Trial. The electronic literature search resulted in 473 potentially relevant articles. Finally, 27 articles were accepted: 21 on cervical (CR) and 6 in lumbar radiculopathy (LR). The mean PEDro score for CR was 6.6 (SD 1.3), and for LR 6.7 (SD 1.6). Traction-oriented techniques are the most frequently chosen treatment form for CR and are efficient in reducing pain and improving functional outcomes. In LR, each of the included publications used a different form of manual therapy, which makes it challenging to summarize knowledge in this group. Of included publications, 93% were either of moderate or low quality, which indicates that quality improvement is necessary for this type of research. 
  • 1.2K
  • 22 Jun 2021
Topic Review
Vascular Smooth Muscle Cells Model
Vascular remodeling is a prominent feature of pulmonary hypertension. This process involves increased muscularization of already muscularized vessels as well as neo-muscularization of non-muscularized vessels. The cell-of-origin of the newly formed vascular smooth muscle cells has been a subject of intense debate in recent years. Identifying these cells may have important clinical implications since it opens the door for attempts to therapeutically target the progenitor cells and/or reverse the differentiation of their progeny. 
  • 1.2K
  • 24 Aug 2021
Topic Review
Violence Prevention Education in Healthcare
Violence from patients and visitors towards healthcare workers is a serious international issue affecting the safety and health of workers, quality of care, and healthcare system sustainability. The main intervention is violence prevention (VP) education for healthcare workers. Both the healthcare environment and reasons for patient violence are complex, making it challenging to evaluate VP education using traditional methods. An alternative realist evaluation approach offers the ability to understand how, why and for whom VP education is effective to prevent violence and related injuries.
  • 1.2K
  • 27 May 2021
Topic Review
SCD and Genetic Propensity for Dementia beyond Apolipoproteinε4
Subjective cognitive decline (SCD) has been described as a probable early stage of dementia, as it has consistently appeared to precede the onset of objective cognitive impairment. SCD is related to many risk factors, including genetic predisposition for dementia. The Apolipoprotein (APOE) ε4 allele, which has been thoroughly studied, seems to explain genetic risk for SCD only partially.
  • 1.2K
  • 14 Mar 2024
Topic Review
Therapeutic Implications of Splanchnic Vein Thrombosis
Splanchnic vein thrombosis (SVT) includes portal (portal vein thrombosis, PVT), mesenteric (mesenteric vein thrombosis, MVT) and splenic vein thrombosis, and Budd-Chiari syndrome (BCS). SVT is generally classified as secondary to an identified risk factor or primitive, unprovoked, when causative factors cannot be identified. While much rarer than common venous thromboembolism (VTE), SVT is often challenging to clinicians for both the identification of the causal disorder and for its therapeutic management. The therapeutic approach of SVT is a clinical challenge and considers the manifestations and the site of thrombosis, the risk of SVT progression, recurrence and bleeding. The decision regarding when to start, as well as the type and the duration of anticoagulant therapy is often made empirically.
  • 1.2K
  • 09 May 2023
Topic Review
Bruxism in Down Syndrome Children
Bruxism is defined as “a repetitive jaw-muscle activity that is characterized by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible,” and is distinguished into sleep bruxism (SB) or awake bruxism (AB), depending on its circadian phenotype. Its role in children and adolescents with Down syndrome is still unclear. Therefore, this study aims to conduct a narrative review of the literature about bruxism in children and adolescents with Down syndrome to identify the prevalence, risk factors, and possible treatments of this disorder. 
  • 1.2K
  • 01 Apr 2021
Topic Review
Safety Training
The purpose of safety training in acquiring knowledge about safety at work is to obtain information about the hazards present in the workplace and the necessary measures worn or kept by employees to protect him/her from one or more hazards associated with the presence of dangerous or harmful factors in the work environment (types of PPE). 
  • 1.2K
  • 27 Oct 2021
Topic Review
Healthcare Waste Management
Healthcare waste (HCW) disposal includes a multitude of disposal methods, including incineration, landfilling and chemical treatments. These rudimentary methods and their growing use present their own problems that negatively impact both the environment and, in turn, damage public health, thus contributing to a global healthcare crisis.
  • 1.2K
  • 28 Apr 2021
Topic Review
Assistive Technologies for Supporting Older Adults' Wellbeing
As people age, they are more likely to develop multiple chronic diseases and experience a decline in some of their physical and cognitive functions, leading to the decrease in their ability to live independently. Innovative technology-based interventions tailored to older adults’ functional levels and focused on healthy lifestyles are considered imperative. 
  • 1.2K
  • 15 Feb 2022
Topic Review
Telehealth and Artificial Intelligence during the COVID-19 Pandemic
Telemedicine enables clinical services to use information technology, video imaging, and telecommunication links to deliver healthcare services at a distance. In contrast to telemedicine, which is defined as the provision of medical services at a distance by a physician, telehealth is an umbrella word that encompasses telemedicine as well as a number of nonphysician services such as telenursing and telepharmacy. Telemedicine is often used for controlling chronic diseases such as cardiovascular diseases, diabetes mellitus, cancer, and mental disorders.
  • 1.2K
  • 07 Mar 2022
Topic Review
Short Vestibular and Cognitive Training for Dyslexia
Dyslexia is a common learning difficulty that does not compromise oral or nonverbal reasoning skills, and it is reported in 5–10% of school-aged children. In the literature, different theories have tried to explain the etiology of this disorder. Phonological impairment is the most known hypothesis for dyslexia; however, others researchers suggested that dyslexia could be due to cerebellar impairments. Interestingly, reading performance and arithmetic skills have been suggested to also be related to cerebellar activity. Several subsequent studies from our group and others examining postural performances in the dyslexia population supported this hypothesis, even if other researchers suggested that such an impairment occurred not only in dyslexia but also in subjects having other types of developmental disorders. A visual attentional deficit has also been reported by Facoetti et al.  and our group showed an abnormal oculomotor pattern in children with dyslexia. Based on these different theories, several researchers have tried to develop different training types in order to improve the reading abilities in children with dyslexia. 
  • 1.2K
  • 05 Nov 2021
Topic Review
Natural Milk Microbiota
Profound bioactivities of raw breastmilk include benefits attributed to the dense and diverse natural microbiota, termed natural microbiota hereafter. Infants benefit from breastfeeding not just nutritionally, but by both ‘seeding and feeding’ the infant gut , providing microbes that seed the naïve gastrointestinal (GI or gut) ecosystem and nutritive components that feed both infant and microbial cells.
  • 1.2K
  • 11 Nov 2021
Topic Review
Erectile Dysfunction and Its Impact on Relationships
Explore how effective partner communication can significantly aid in the treatment of erectile dysfunction (ED) in this insightful article from ED Generic Store. Delving into the importance of emotional connection, open dialogue, and mutual support, this piece offers practical guidance for couples navigating the complexities of ED together. Learn how fostering trust, sharing concerns, and exploring lifestyle changes can enhance intimacy and improve overall relationship satisfaction. Gain valuable insights into the role of professional help and the power of celebrating progress as partners work collaboratively towards overcoming ED and revitalizing their connection.
  • 1.2K
  • 09 May 2024
Topic Review
Arboviral Disease Outbreaks in the Pacific Islands Countries
Arthropod-borne viral (arboviral) diseases are a significant global health problem accounting for >17% of all infectious disease cases and 1 million deaths worldwide annually. Arboviral diseases are infections caused by over 100 viruses belonging to the Flaviviridae, Togaviridae, Reoviridae, Bunyaviridae, Rhabdoviridae and Orthomyxoviridae families. These viruses are spread to humans through arthropods, including mosquitos, ticks, and flies.
  • 1.2K
  • 17 Jan 2022
Topic Review
Glycosaminoglycans in Mucopolysaccharidosis
Mucopolysaccharidosis (MPS) consists of a group of inherited lysosomal storage disorders that are caused by a defect of certain enzymes that participate in the metabolism of glycosaminoglycans (GAGs). The abnormal accumulation of GAGs leads to progressive dysfunctions in various tissues and organs during childhood, contributing to premature death.
  • 1.2K
  • 23 Mar 2023
Topic Review
Innate Immunity Promotes Programmed Death of Individual Organisms
Over-activation of innate immunity in response to bacterial or viral (including COVID-19) infections, massive trauma, or ischemia/reperfusion often causes severe illness and death. We suggest that such severe outcomes may be manifestations of an altruistic suicidal strategy protecting the entire population from the spread of pathogens and from dangerous pathologies rather than aberrant hyperstimulation of defense responses. 
  • 1.2K
  • 22 Dec 2021
Topic Review
The Ketogenic Diet and Cardiovascular Diseases
The ketogenic diet has been shown to have a multifaceted effect on the prevention and treatment of cardiovascular diseases (CVD). Among other aspects, it has a beneficial effect on the blood lipid profile, even compared to other diets. It shows strong anti-inflammatory and cardioprotective potential, which is due, among other factors, to the anti-inflammatory properties of the state of ketosis, the elimination of simple sugars, the restriction of total carbohydrates and the supply of omega-3 fatty acids. In addition, ketone bodies provide “rescue fuel” for the diseased heart by affecting its metabolism. They also have a beneficial effect on the function of the vascular endothelium, including improving its function and inhibiting premature ageing. The ketogenic diet has a beneficial effect on blood pressure and other CVD risk factors through, among other aspects, weight loss. The evidence cited is often superior to that for standard diets, making it likely that the ketogenic diet shows advantages over other dietary models in the prevention and treatment of cardiovascular diseases.
  • 1.2K
  • 07 Sep 2023
Topic Review
Bio-Preservation of Meat by Lactic Acid Bacteria Strains
Meat and some meat products are highly perishable due to their high-water content, pH, and high content of nutrients. Therefore, spoilage control in these products is one of the critical challenges in the food industry. On the other hand, the increasing widespread awareness about the undesirable effects of synthetic preservatives has promoted the breakthrough of the use of natural compounds or bio-preservation technology. Bio-preservation implies the application of microorganisms or their metabolites to extend the shelf life of food products. In this regard, according to the ancient and safe use of fermentation by lactic acid bacteria (LAB), their application in the bio-preservation of meat and meat products is gaining more attention.
  • 1.2K
  • 11 Jul 2023
Topic Review
Hotspots and Frontiers of Urban Floods
Current research shows that the number of papers published in the field of urban flooding is generally increasing year by year, and the research focus has shifted from exploring hydrological processes to adopting advanced management measures to solve urban flooding problems. 
  • 1.2K
  • 15 Dec 2021
Topic Review
Adverse Perinatal Outcomes in COVID-19 Infected Pregnant Women
Several adverse maternal, fetal, and neonatal effects were significantly higher in COVID-19 infected pregnant women than non-infected. These included maternal death, preeclampsia, cesarean section delivery, fetal distress, preterm birth, low birth weight, stillbirth, low Apgar score at the fifth minute, and admission to NICU. The comorbidity conditions had no added risk of being infected with COVID-19 infection during pregnancy. Therefore, a COVID-19 infected pregnant woman should be treated with special precautions to avoid and minimize the identified adverse events during perinatal care. 
  • 1.2K
  • 24 Jan 2022
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