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Topic Review
JAK/STAT Signaling Pathway Inhibitors
The JAK/STAT pathway is evolutionarily conserved, and it includes three main players: a ligand-receptor complex, for example, cytokines such as IL-2, IL-4, IL-6, IL-12, and IL-23; growth hormone (GH) growth factors (GF) and their receptors, one or two kinases belonging to the JAK family and one or two members of the STAT family.
  • 1.2K
  • 26 Apr 2023
Topic Review
Parkinson’s Disease and NRF2
NRF2 (Nuclear Factor-Erythroid 2 Like 2) is a transcription factor that orchestrates the cellular response to oxidative stress. The regulation of NRF2 signalling has been shown to be a promising strategy to modulate the progression of the neurodegeneration associated to Parkinson’s disease. The NRF2 pathway has been shown to be affected in patients with this disease, and activation of NRF2 has neuroprotective effects in preclinical models, demonstrating the therapeutic potential of this pathway.
  • 1.2K
  • 03 Nov 2021
Topic Review
Aquaporins Regulation by Arbuscular Mycorrhizae
Despite an intensive research in the field of aquaporins, the relationship between aquaporins and plant responses to water deficit remains still unresolved. However, several authors have recognized the importance of aquaporins for both nutrient and water exchanges during mycorrhizal symbiosis. We have conducted investigations showing that the AM symbiosis regulates the expression of a wide number of aquaporin genes in maize, including members of the different aquaporin subfamilies. Several of these AM-regulated aquaporins where functionally characterized in heterologous systems with Xenopus laevis oocytes and by yeast complementation. It was shown that they can transport water, but also other molecules of physiological importance for plant performance under both normal and stress conditions (glycerol, urea, ammonia, boric acid, silicon or hydrogen peroxide). AM plants grew and developed better than non-AM plants under the different conditions assayed. Thus, the investigation suggests that the well-known better performance of AM plants under drought stress may be due not only to the improved water movement in their tissues, but also to the mobilization of compounds with a role in abiotic stress tolerance such as glycerol, N compounds, signalling molecules or metalloids.
  • 1.2K
  • 29 Oct 2020
Topic Review
LAMA2-Related Muscular Dystrophy
LAMA2-related muscular dystrophy is a disorder that causes weakness and wasting (atrophy) of muscles used for movement (skeletal muscles). This condition varies in severity, from a severe, early-onset type to a milder, late-onset form.
  • 1.2K
  • 23 Dec 2020
Topic Review
Frontonasal Dysplasia
Frontonasal dysplasia is a condition that results from abnormal development of the head and face before birth. People with frontonasal dysplasia have at least two of the following features: widely spaced eyes (ocular hypertelorism); a broad nose; a slit (cleft) in one or both sides of the nose; no nasal tip; a central cleft involving the nose, upper lip, or roof of the mouth (palate); incomplete formation of the front of the skull with skin covering the head where bone should be (anterior cranium bifidum occultum); or a widow's peak hairline.
  • 1.2K
  • 25 Dec 2020
Topic Review
Nuclear Matrix Metalloproteinases
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for the degradation of a wide range of extracellular matrix proteins, which are involved in many cellular processes to ensure the normal development of tissues and organs. Overexpression of MMPs has been observed to facilitate cellular growth, migration, and metastasis of tumor cells during cancer progression. A growing number of these proteins are being found to exist in the nuclei of both healthy and tumor cells, thus highlighting their localization as having a genuine purpose in cellular homeostasis. The mechanism underlying nuclear transport and the effects of MMP nuclear translocation have not yet been fully elucidated. To date, nuclear MMPs appear to have a unique impact on cellular apoptosis and gene regulation, which can have effects on immune response and tumor progression, and thus present themselves as potential therapeutic targets in certain types of cancer or disease. Herein, we highlight and evaluate what progress has been made in this area of research, which clearly has some value as a specific and unique way of targeting the activity of nuclear matrix metalloproteinases within various cell types. 
  • 1.2K
  • 05 Jan 2021
Topic Review
Dermatitis Herpetiformis
Dermatitis herpetiformis (DH) is a blistering dermatosis, which shares common immunologic features with celiac disease (CD).
  • 1.2K
  • 12 Oct 2021
Topic Review
Estrogens and Lung Cancer
Malignant neoplasms are among the most common diseases and are responsible for the majority of deaths in the developed world. In contrast to men, available data show a clear upward trend in the incidence of lung cancer in women, making it almost as prevalent as breast cancer. Women might be more susceptible to the carcinogenic effect of tobacco smoke than men. Furthermore, available data indicate a much more frequent mutation of the tumor suppressor gene-p53 in non-small cell lung cancer (NSCLC) female patients compared to males. Another important factor, however, might lie in the female sex hormones, whose mitogenic or carcinogenic effect is well known. Epidemiologic data show a correlation between hormone replacement therapy (HRT) or oral contraceptives (OCs), and increased mortality rates due to the increased incidence of malignant tumors, including lung cancer. Interestingly, two types of estrogen receptors have been detected in lung cancer cells: ERα and ERβ. The presence of ERα has been detected in tissues and non-small-cell lung carcinoma (NSCLC) cell lines. In contrast, overexpression of ERβ is a prognostic marker in NSCLC.
  • 1.2K
  • 22 Jan 2021
Topic Review
Rhizosphere Associated Bacteria
The abundance of nutrient accumulation in rhizosphere soils has placed the rhizosphere as an “epicenter” of bacterial concentrations. Nonetheless, over the years, little attention has been given to bacterial inoculants and soil-like substrates. The reason is that many farmers and experiments have focused on chemical fertilizers as an approach to improve plant growth and yield. Therefore, we focused on assessing the application of rhizosphere soil and its associated bacteria for biotechnological applications.
  • 1.2K
  • 23 Feb 2021
Topic Review
Resveratrol in COVID-19-Associated Hemostatic Disorders
By virtue of its anti-thrombotic and anti-inflammatory properties, resveratrol would be expected to lower COVID-19-associated mortality, which is well known to be increased by thrombosis and inflammation.
  • 1.2K
  • 01 Apr 2021
Topic Review
Acute Heart Failure Syndrome
A working definition of heart failure (HF) in children is “a progressive clinical and pathophysiological syndrome caused by cardiovascular and noncardiovascular abnormalities that results in characteristic signs and symptoms including edema, respiratory distress, growth failure, and exercise intolerance and accompanied by circulatory, neurohormonal, and molecular derangements”.
  • 1.2K
  • 17 May 2021
Topic Review
Early Fetal Growth Restriction
Early fetal growth restriction (FGR) is a complex and multifactorial disorder affecting fetal development. Most cases are related to uteroplacental dysfunction, while non-placental etiologies include chromosomal/genetic anomalies, congenital infections and inborn errors of metabolism.
  • 1.2K
  • 27 May 2021
Topic Review
α-Helices in the T3SEs
Type III Secretion Systems (T3SSs) are multicomponent nanomachines located at the cell envelope of Gram-negative bacteria. Their main function is to transport bacterial proteins either extracellularly or directly into the eukaryotic host cell cytoplasm. Type III Secretion effectors (T3SEs), latest to be secreted T3S substrates, are destined to act at the eukaryotic host cell cytoplasm and occasionally at the nucleus, hijacking cellular processes through mimicking eukaryotic proteins. T3SE families adopt novel folds to target eukaryotic functions. These folds comprise a high helical content, which possibly reflects the specific requirements from T3SS effectors. In particular, effectors must (i) be able to be easily unfolded, (ii) cross the narrow T3S channel, (iii) be highly folded as soon as they will be found inside the host cell, in order to evade the host defense mechanisms, and (iv) display functional competence and structural plasticity in their final destination. α-helices can optimally fulfil these requirements.
  • 1.2K
  • 06 Jun 2021
Topic Review
Sarcopenia and Cognitive Function
Sarcopenia is a geriatric syndrome characterized by the progressive degeneration of muscle mass and function. It is associated with cognitive impairment, defined as a decline in cognitive domains such as language, memory, reasoning, social cognition, planning, making decisions, and solving problems. Several studies have shown that skeletal muscle can regulate brain functions, including mood, learning, locomotor activity, and neuronal injury protection, showing the existence of muscle-brain crosstalk. 
  • 1.2K
  • 04 Jun 2021
Topic Review
Epithelial Membrane Protein 3 (EMP3)
Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). 
  • 1.2K
  • 10 Jun 2021
Topic Review
Climate Change and Residential Buildings
Climate change is expected to influence cooling and heating energy demand of residential buildings and affect overall thermal comfort. Towards this end, the heating (HDD) and cooling (CDD) degree-days along with HDD + CDD were computed from an ensemble of seven high-resolution bias-corrected simulations attained from EURO-CORDEX under two Representative Concentration Pathways (RCP4.5 and RCP8.5) for mainland Portugal. 
  • 1.2K
  • 14 Jul 2021
Topic Review
Towards Higher Quality of Recycled Plastics
The increasing consumption of plastics and plastic products results in correspondingly substantial volumes of waste, which poses considerable environmental burdens. With the ongoing environmental actions, the application of circular economy on this waste stream is becoming inevitable. The quality of recycled plastic is generally determined by the homogeneity of the recovered plastic feed. 
  • 1.2K
  • 16 Dec 2021
Topic Review
Neuroprotection of Insulin-like Growth Factor-1
Insulin-like growth factor-1 (IGF-1) and its binding proteins and receptors are widely expressed in the central nervous system (CNS), proposing IGF-1-induced neurotrophic actions in normal growth, development, and maintenance. However, while there is convincing evidence that the IGF-1 system has specific endocrine roles in the CNS, the concept is emerging that IGF-I might be also important in disorders such as ischemic stroke, brain trauma, Alzheimer’s disease, epilepsy, etc., by inducing neuroprotective effects towards glutamate-mediated excitotoxic signaling pathways. Research in rodent models has demonstrated rescue of pathophysiological and behavioral abnormalities when IGF-1 was administered by different routes, and several clinical studies have shown safety and promise of efficacy in neurological disorders of the CNS.
  • 1.2K
  • 03 Mar 2022
Topic Review
Theoretical Model of Industrial Innovation Ecosystem
This entry takes the industrial innovation ecosystem as the research object and the realization of green development as the goal, discussing the temporal and spatial evolution of coupling coordination degree of industrial innovation ecosystem from the perspective of system view. Based on the data of 30 provinces in China from 2010 to 2021, the spatial and temporal pattern distribution and spatial connection evolution of synergy among the three subsystems of industrial innovation ecosystem are studied by using coupling coordination degree model, trend surface model and gravity model. It is found that during the study period, the coupling relationship between the three subsystems is in a dynamic upward state. The regions with high values and rapid growth are distributed in the key areas of the national economic development strategy. At the same time, they have the characteristics of “positive U-shaped first and then inverted U-shaped” in the east-west and north-south directions; the spatial connection strength of coupling coordination degree shows that the spatial connection strength of the eastern region is significantly greater than that of the western region. With the improvement of spatial connection strength, a radial coupling network centered on Beijing Tianjin Tangshan region and the Yangtze River Delta is formed, which is of core significance to promote the coordinated development of industrial innovation ecosystem. 
  • 1.2K
  • 13 Apr 2022
Topic Review
Biofunctionalization of the Tissue Engineered Heart Valves
Valve replacement is the mainstay of treatment for end-stage valvular heart disease, but varying degrees of defects exist in clinically applied valve implants. A mechanical heart valve requires long-term anti-coagulation, but the formation of blood clots is still inevitable. A biological heart valve eventually decays following calcification due to glutaraldehyde cross-linking toxicity and a lack of regenerative capacity. The goal of tissue-engineered heart valves is to replace normal heart valves and overcome the shortcomings of heart valve replacement commonly used in clinical practice. Surface biofunctionalization has been widely used in various fields of research to achieve functionalization and optimize mechanical properties.
  • 1.2K
  • 28 Sep 2022
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