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Topic Review
Curcumin against Neurodegenerative Diseases
Neurodegenerative diseases (NDs) are one of major public health problems and their impact is continuously growing. Curcumin has been proposed for the treatment of several of these pathologies, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to the ability of this molecule to reduce inflammation and aggregation of involved proteins. 
  • 1.2K
  • 21 Apr 2021
Topic Review
Multimeric PET Radioligands
Multimeric PET radioligands consist of identical binding motifs (pharmacophores) connected to a single backbone (linker) attached to a group, which can be labeled with a positron-emitting radionuclide suitable for PET molecular imaging (radiolabeled domain). 
  • 1.2K
  • 25 May 2021
Topic Review
Vanadium Oxides
Vanadium-based compounds exhibit a range of oxidation states, including V5+, V4+, V3+, and V2+, making them feasible to composite with many other anions and cations to form vanadium oxides, vanadium carbides, vanadium nitrides, vanadium sulphides, vanadium phosphates, and metal vanadates.Among them, vanadium oxides have attracted interest for energy storage in the past decades.
  • 1.2K
  • 24 May 2021
Topic Review
NO Signaling Pathways in Aging
Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. 
  • 1.2K
  • 12 Aug 2021
Topic Review
ICIs-Related Cardiotoxicity in Different Types of Cancer
Immune checkpoint inhibitors (ICIs), antibodies that target the checkpoints in immune cells, work to activate inhibited T-cells and other cells of the innate and adaptive arms, resulting in the robust activation of the immune system and productive antitumor immune responses. However, ICIs-related cardiotoxicity has been recognized as a rare but fatal consequence. Although there has been extensive research based on different types of ICIs, these studies have not indicated whether cardiotoxicity is specific to a type of cancer.
  • 1.2K
  • 13 Jul 2022
Topic Review
UV-A Photocatalysis in Livestock and Poultry Farming
As the scale of the livestock industry has grown with the increase in the demand for livestock and poultry products, gaseous emissions, an unwanted side effect of livestock and poultry production, are also increasing. Various mitigation technologies have been developed to reduce such air pollution, and the mitigation technologies are divided mainly into “source-based type” (meant to fundamentally reduce the emissions) and “end-of-pipe type” (physicochemical and biological treatment of the output from barns to reduce the release into the environment). Ultraviolet light (UV) can be considered as both end-of-pipe (treating exhaust air from barns) and source-based type (treating air inside the barn).
  • 1.2K
  • 20 Sep 2022
Topic Review
Amyotrophic Lateral Sclerosis Pathophysiology
Amyotrophic lateral sclerosis (ALS) is a traumatic condition, whereby motor neurons are lost eventually leading to death within a couple of years. There is no effective treatment, due primarily to a lack of understanding as to the relevant pathophysiological changes occurring. The biological underpinnings of ALS is described, highlighting the role of the gut microbiome, glia, muscles and the changes at the neuromuscular junction. It is proposed that alterations in the mitochondrial melatonergic pathway are a crucial aspect of ALS pathophysiology that underpins the changes in intercellular interactions that drive ALS. Many of these initial changes  seem to arise in the gut, indicating that this may be an important site for evaluation and treatment in the prevention of ALS. It is also proposed that glyphosate-based herbicides (weedkillers) exposure may be a relevant aspect of ALS susceptibility and progression. 
  • 1.2K
  • 09 Jan 2023
Topic Review
Role of Endoscopy in Upper Gastrointestinal Cancers
Upper gastrointestinal (GI) malignancy is a leading cause of cancer-related morbidity and mortality. Upper endoscopy has an established role in diagnosing and staging upper GI cancers, screening for pre-malignant lesions, and providing palliation in cases of advanced malignancy. New advances in endoscopic techniques and technology have improved diagnostic accuracy and increased the therapeutic potential of upper endoscopy.
  • 1.2K
  • 16 Jan 2023
Topic Review
Proinflammatory Cytokines in Bone Metabolism
Bone is a mineralized connective tissue that is constantly renewed to maintain its mechanical properties. Osteoblasts are responsible for extracellular matrix synthesis, while osteoclasts resorb damaged bone, and the osteocytes have a regulatory role in this process, releasing growth factors and other proteins. A balanced activity among these actors is necessary for healthy bone remodeling. In obesity, several mechanisms may trigger incorrect remodeling, increasing bone resorption to the detriment of bone formation rates.
  • 1.2K
  • 06 May 2023
Topic Review
Molecular Markers in Marker-Assisted Selection in Bread Wheat
As one of the essential cereal crops, wheat provides 20% of the calories and proteins consumed by humans. Due to population expansion, dietary shift and climate change, it is challenging for wheat breeders to develop new varieties for meeting wheat production requirements. Marker-assisted selection (MAS) has distinct advantages over conventional selection in plant breeding, such as being time-saving, cost-effective and goal-oriented. Here gives a description of different molecular markers: sequence tagged site (STS), simple sequence repeat (SSR), genotyping by sequencing (GBS), single nucleotide polymorphism (SNP) arrays, exome capture, Kompetitive Allele Specific PCR (KASP), cleaved amplified polymorphic sequence (CAPS), semi-thermal asymmetric reverse PCR (STARP) and genotyping by target sequencing (GBTS).
  • 1.2K
  • 07 Jul 2023
Topic Review
Modern MultiPort Converter Technologies
The integration of renewable energy sources (RES) as distributed generation units to the power grid has been accelerated by the rising demand for energy and the growing concern over the environmental effects of conventional sources. At the same time, modern electric vehicles (EV) are demonstrating a promising ability to decrease the consumption of fossil fuels. The issues related to a combination of various renewable energy sources to fulfil the load requirements can be solved by the application of multi-input–output architecture that is properly designed. In order to increase the driving range of EVs, several energy sources, including ultracapacitors and fuel cells, should be connected and operate in combination with a battery storage system. To manage these energy sources with various voltage-current characteristics, the same concept can be applied.
  • 1.2K
  • 12 Sep 2023
Topic Review
Ischemia with No Obstructive Coronary Arteries
Ischemia with no obstructive coronary arteries (INOCA) is a relatively newly discovered ischemic phenotype that affects patients similarly to obstructive coronary artery disease (CAD) but has a unique pathophysiology and epidemiology. Patients with INOCA present with ischemic signs and symptoms but no obstructive CAD seen on coronary CTA or invasive coronary angiography, which can assess epicardial vessels.
  • 1.2K
  • 20 Sep 2023
Topic Review
Pigmented Purpuric Dermatoses
Pigmented purpuric dermatoses (PPD) encompass a group of chronic skin conditions characterized by the presence of petechiae, purpura, and pigmentation changes.
  • 1.2K
  • 07 Mar 2024
Topic Review
Fibroblast Subsets in Colorectal cancer
CAFs are defined as fibroblasts surrounding malignant tumor cells and are the most abundant cell type in the tumor microenvironment of colorectal cancer (CRC). CAFs consist of various functionally heterogeneous subsets which can promote or restrain cancer progression. Although most previous research has focused on the biology of epithelial cells, accumulating evidence shows that certain CAF subsets can also importantly contribute to tumor initiation and progression, thereby possibly providing avenues for improvement of clinical care for CRC patients. However, attention needs to be paid to comprehensive characterization and reporting of the subsets being investigated in CAF studies to enable more precise identification and targeting of “unfavorable” CAFs in advanced CRC.
  • 1.2K
  • 28 Jan 2021
Topic Review
FLASH Radiotherapy—Radiobiological Rationale
FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy through better sparing of the normal tissue.
  • 1.2K
  • 13 Apr 2021
Topic Review
Deposition Parameters on the Microstructure of Multilayer Films
Multilayer films with high-density layer interfaces have been studied widely because of the unique mechanical and functional properties. Magnetron sputtering is widely chosen to fabricate multilayer films because of the convenience in controlling the microstructure. 
  • 1.2K
  • 28 Dec 2021
Topic Review
Protein Lipidation
Proteins play indispensable roles in maintaining cell survival, and their functions are often regulated by post-translational modifications (PTMs), in which proteins are proteolytically cleaved or enzymatically conjugated with modifying groups. Various enzymes, including kinases, phosphatases, transferases, and ligases, catalyze approximately 500 discrete PTMs of a diverse set of proteins. PTMs regulate diverse activities of a colossal number of proteins. For example, various types of lipids can be covalently linked to proteins enzymatically or non-enzymatically. Protein lipidation is perhaps not as extensively studied as protein phosphorylation, ubiquitination, or glycosylation although it is no less significant than these modifications. Evidence suggests that proteins can be attached by at least seven types of lipids, including fatty acids, lipoic acids, isoprenoids, sterols, phospholipids, glycosylphosphatidylinositol anchors, and lipid-derived electrophiles.
  • 1.2K
  • 11 Mar 2022
Topic Review
Bioactive Compounds in Oral Stem Cell-Meditated Regeneration
Stem cells are a well-known autologous pluripotent cell source, having excellent potential to develop into specialized cells, such as brain, skin, and bone marrow cells. The oral cavity is reported to be a rich source of multiple types of oral stem cells, including the dental pulp, mucosal soft tissues, periodontal ligament, and apical papilla. Oral stem cells were useful for both the regeneration of soft tissue components in the dental pulp and mineralized structure regeneration, such as bone or dentin, and can be a viable substitute for traditionally used bone marrow stem cells.  The role of bioactive compounds in oral stem cell-meditated regeneration is discussed.
  • 1.2K
  • 11 Oct 2022
Topic Review
Tooth Diversity
Although the evolution of tooth structure seems highly conserved, remarkable diversity exists among species due to different living environments and survival requirements. Along with the conservation, this diversity of evolution allows for the optimized structures and functions of teeth under various service conditions, providing valuable resources for the rational design of biomimetic materials. 
  • 1.2K
  • 03 Feb 2023
Topic Review
Drought Monitoring and Forecasting across Turkey
Drought is the consequence of a significant decline in the hydrological variables such as precipitation, soil moisture, and streamflow that undesirably affects all living beings. There are various indices for drought monitoring and assessment that can identify the characteristics of drought, such as magnitude, severity, and duration. They are obtained from hydro-meteorological indicators, such as precipitation, temperature, runoff, soil moisture, reservoir storage, and groundwater level. Some indices are more appropriate than others for certain circumstances, such as the location of the study area, drought type, and availability of data. With the development of meteorological satellites and RS technology on the one hand and the emergence of data-mining techniques on the other hand, a lot of research has been conducted in the field of drought monitoring and forecasting (DMF) using these technologies. 
  • 1.2K
  • 06 May 2023
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