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Topic Review
Oncogenic Tyrosine Phosphatases
Despite a large number of therapeutic options available, malignant melanoma remains a highly fatal disease, especially in its metastatic forms. The oncogenic role of protein tyrosine phosphatases (PTPs) is becoming increasingly clear, paving the way for novel antitumor treatments based on their inhibition. In this review, we present the oncogenic PTPs contributing to melanoma progression and we provide, where available, a description of new inhibitory strategies designed against these enzymes and possibly useful in melanoma treatment. Considering the relevance of the immune infiltrate in supporting melanoma progression, we also focus on the role of PTPs in modulating immune cell activity, identifying interesting therapeutic options that may support the currently applied immunomodulating approaches.
  • 1.2K
  • 13 Oct 2020
Topic Review
Cutaneous Findings in NF1
Neurofibromatosis type 1 (NF1) is a complex autosomal dominant disorder associated with germline mutations in the NF1 tumor suppressor gene. NF1 belongs to a class of congenital anomaly syndromes called RASopathies, a group of rare genetic conditions caused by mutations in the Ras/mitogen-activated protein kinase pathway. Generally, NF1 patients present with dermatologic manifestations.
  • 1.2K
  • 02 Feb 2021
Topic Review
VLP-Based Vaccines for Trypanosomatid Diseases
Virus-like particle (VLP) technology is involved in many vaccines, including those undergoing studies related to COVID-19. The potential use of VLPs as vaccine adjuvants opens an opportunity for the use of protozoan antigens for the development of vaccines against diseases caused by Trypanosoma cruzi, Leishmania spp., and Trypanosoma brucei. 
  • 1.2K
  • 21 Jun 2021
Topic Review
Peri-Urban Ecosystem Services in Europe
The phenomenon of urbanization affecting our era has seen the shift of the city from compact and well-defined structures to agglomerations with a seamless expansion. This has led to several environmental consequences that have affected the urbanized areas and the surroundings. The peri-urban areas may be the main urban design and planning challenge of the 21st century. These hybrid landscapes, characterized by high fragmentation, can be turned into opportunities to improve the sustainability and quality of urban areas, generating multiple economic, social and environmental benefits. Areas beyond the immediate urban core can be considered a zone of influence, which represent a critical resource in terms of provisioning, regulating, supporting services and cultural ecosystem services.
  • 1.2K
  • 01 Sep 2021
Topic Review
Biomass Valorization of Walnut Shell for Liquefaction Efficiency
Globally, lignocellulosic biomass has great potential for industrial production of materials and products, but this resource must be used in an environmentally friendly, socially acceptable and sustainable manner. Wood and agricultural residues such as walnut shells as lignocellulosic biomass are one of the most affordable and important renewable resources in the world, which can partially replace fossil resources. The entry revealed that walnut shell biomass can be effectively liquefied into glycerol using H2SO4 as the catalyst, with liquefaction efficiency ranging from 89.21 to 90.98%.
  • 1.2K
  • 24 Jan 2022
Topic Review
Hydrogen Production Using Dark Fermentation
Anaerobic digestion (AD) is an established process used across the world for the conversion of biomass and organic waste into methane, a renewable energy vector.
  • 1.2K
  • 24 Jan 2022
Topic Review
Fundus Autofluorescence Imaging
Non-invasive in vivo FAF imaging is based on the visualization of endogenous fluorophores in the ocular fundus. The first scanning laser ophthalmoscope was presented in 1980 by Webb et al. and continuously improved in the following years. FAF imaging using confocal scanning laser ophthalmoscopy (cSLO) was described in 1995. Since then, continuous and further developments have strengthened FAF imaging to become a safe and reproducible imaging method that is essential for the routine clinical examination of various chorioretinal diseases. Nowadays, different commercially available devices are used to record FAF. They may not be absolutely equivalent and comparable. Therefore, it is essential to understand the basic principles of FAF imaging techniques and to know the different imaging systems.
  • 1.2K
  • 28 Apr 2022
Topic Review
Influence of SDG on Firm Performance
The Sustainable Development Goals (SDGs) seek to enhance human dignity and prosperity while simultaneously safeguarding the planet’s fundamental biophysical processes and ecosystem services. They recognize that reducing poverty and inequality necessitates long-term economic growth, peace, and justice strategies, as well as strategies to address basic social needs such as education, health, social protection, and job opportunities—all while addressing climate change and improving environmental protection.
  • 1.2K
  • 23 May 2022
Topic Review
Baggio–Yoshinari Syndrome
Baggio–Yoshinari Syndrome (BYS) is an emerging Brazilian tick-borne infectious disease that clinically mimics Lyme Disease (LD) present in the Northern Hemisphere. LD is caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex and transmitted by Ixodid ticks of complex Ixodes rticinus. On the contrary, BYS is transmitted by hard Ixodid ticks of the genera Amblyomma, Rhipicephalus and Dermacentor. In 1992, the first cases of BYS were described in patients that developed EM rash, flu-like symptoms and arthritis after tick bite episodes. Since these findings, research in BYS has been developing for more than 30 years and shows that its epidemiological, clinical and laboratorial features are different from LD. Borrelia burgdorferi was never isolated in Brazil. In addition, specific serologic tests have shown little positivity. Furthermore, peripheral blood analysis of patients using electron microscopy exhibited structures resembling spirochete-like microorganisms or the latent forms of spirochetes (L form or cell wall deficient bacteria).
  • 1.2K
  • 16 Sep 2022
Topic Review
Shelter in Place
Shelter in place (also known as a Shelter In-Place Warning, SAME code SPW) is to seek safety within the building one already occupies, rather than to evacuate the area or seek a community emergency shelter. The American Red Cross says the warning is issued when "chemical, biological, or radiological contaminants may be released accidentally or intentionally into the environment" and residents should "select a small, interior room, with no or few windows, taking refuge there."
  • 1.2K
  • 10 Oct 2022
Topic Review
Zone File
A Domain Name System (DNS) zone file is a text file that describes a DNS zone. A DNS zone is a subset, often a single domain, of the hierarchical domain name structure of the DNS. The zone file contains mappings between domain names and IP addresses and other resources, organized in the form of text representations of resource records (RR). A zone file may be either a DNS master file, authoritatively describing a zone, or it may be used to list the contents of a DNS cache.
  • 1.2K
  • 13 Oct 2022
Topic Review
North American Datum
The North American Datum (NAD) is the horizontal datum now used to define the geodetic network in North America. A datum is a formal description of the shape of the Earth along with an "anchor" point for the coordinate system. In surveying, cartography, and land-use planning, two North American Datums are in use for making lateral or "horizontal" measurements: the North American Datum of 1927 (NAD 27) and the North American Datum of 1983 (NAD 83). Both are geodetic reference systems based on slightly different assumptions and measurements. Vertical measurements, based on distances above or below Mean High Water (MHW), are calculated using the North American Vertical Datum of 1988 (NAVD 88). NAD 83, along with NAVD 88, is set to be replaced with a new GPS- and gravimetric geoid model-based geometric reference frame and geopotential datum in 2022.
  • 1.2K
  • 20 Oct 2022
Topic Review
AeroVironment Global Observer
The AeroVironment Global Observer is a concept for a high-altitude, long endurance unmanned aerial vehicle, designed by AeroVironment (AV) to operate as a stratospheric geosynchronous satellite system with regional coverage. Two Global Observer aircraft, each flying for up to a week at an altitude of 55,000 to 65,000 feet (17,000 to 20,000 m), could alternate coverage over any area on the earth, providing a platform for communications relays, remote sensing, or long-term surveillance. In addition to flying above weather and above other conventional aircraft, operation at this altitude permits communications and sensor payloads on the aircraft to service an area on the surface of the earth up to 600 miles (970 km) in diameter, equivalent to more than 280,000 square miles (730,000 km2) of coverage. Global Observer may offer greater flexibility than a satellite and longer duration than conventional manned and unmanned aircraft.
  • 1.2K
  • 20 Nov 2022
Topic Review
Triumph I4
The Triumph Four Cylinder or Triumph I4 engine is a cast-iron overhead valve straight-four engine produced by Standard Triumph. Introduced in their Standard Eight in 1953, it was used in a wide range of Triumph vehicles, including the Triumph Herald, Triumph Spitfire and certain Dolomites.
  • 1.2K
  • 22 Nov 2022
Topic Review
Topoľčany Pogrom
The Topoľčany pogrom was an anti-Jewish riot in Topoľčany, Slovakia on 24 September 1945 and the best-known incident of post-Holocaust violence against Jews in Slovakia. The underlying cause was resurgent antisemitism directed at Jewish Holocaust survivors who demanded the return of property that had been stolen during the Holocaust. Rumors spread that a local Catholic school would be nationalized and the nuns who taught there replaced by Jewish teachers. On the morning of 24 September, women demonstrated against the nationalization of the school, blaming Jews. That same day, a Jewish doctor was vaccinating children at the school. He was accused of poisoning non-Jewish children, sparking a riot. The police were unable to prevent it, and a local garrison of soldiers joined in. About forty-seven Jews were injured, and fifteen had to be hospitalized. In the immediate aftermath of the events, international coverage embarassed the Czechoslovak authorities and the Czechoslovak Communist Party exploited the riots to accuse the democratic authorities of ineffectiveness. A 2004 documentary film about the rioting, Miluj blížneho svojho ("Love thy neighbor"), sparked increased discussion of the events. The next year, the mayor of Topoľčany issued an official apology.
  • 1.2K
  • 28 Nov 2022
Topic Review
Power-Flow Study
In power engineering, the power-flow study, or load-flow study, is a numerical analysis of the flow of electric power in an interconnected system. A power-flow study usually uses simplified notations such as a one-line diagram and per-unit system, and focuses on various aspects of AC power parameters, such as voltages, voltage angles, real power and reactive power. It analyzes the power systems in normal steady-state operation. Power-flow or load-flow studies are important for planning future expansion of power systems as well as in determining the best operation of existing systems. The principal information obtained from the power-flow study is the magnitude and phase angle of the voltage at each bus, and the real and reactive power flowing in each line. Commercial power systems are usually too complex to allow for hand solution of the power flow. Special purpose network analyzers were built between 1929 and the early 1960s to provide laboratory-scale physical models of power systems. Large-scale digital computers replaced the analog methods with numerical solutions. In addition to a power-flow study, computer programs perform related calculations such as short-circuit fault analysis, stability studies (transient and steady-state), unit commitment and economic dispatch. In particular, some programs use linear programming to find the optimal power flow, the conditions which give the lowest cost per kilowatt hour delivered. A load flow study is especially valuable for a system with multiple load centers, such as a refinery complex. The power flow study is an analysis of the system’s capability to adequately supply the connected load. The total system losses, as well as individual line losses, also are tabulated. Transformer tap positions are selected to ensure the correct voltage at critical locations such as motor control centers. Performing a load flow study on an existing system provides insight and recommendations as to the system operation and optimization of control settings to obtain maximum capacity while minimizing the operating costs. The results of such an analysis are in terms of active power, reactive power, magnitude and phase angle. Furthermore, power-flow computations are crucial for optimal operations of groups of generating units. The Open Energy Modelling Initiative promotes open source load-flow models and other types of energy system models.
  • 1.2K
  • 06 Dec 2022
Topic Review
Titanium (IV) Oxide in Dermal Formulations
The widespread role of titanium (IV) oxide (TiO2) in many industries makes this substance of broad scientific interest. TiO2 can act as both a photoprotector and photocatalyst, and the potential for its role in both applications increases when present in nanometer-sized crystals. Its sunlight-scattering properties are used extensively in sunscreens.
  • 1.2K
  • 12 May 2023
Topic Review
Sustainable Textiles from Unconventional Biomaterials
Various studies have shown that vegan leather alternatives are particularly suitable because they mimic the properties of real leather, and the qualities of the bio-based materials combined with textile substrates are relatively close to real leather. Cactus plants require less water and can completely replace real leather. The use of cactus as a source of sustainable textiles and leather offers numerous environmental benefits. This is due to the fact that harvesting the cactus does not harm the plant or its roots, allowing it to keep growing and sequestering carbon dioxide.
  • 1.2K
  • 02 Aug 2023
Topic Review
Sustainability in Airports Ecosystem
Economic, social, and environmental sustainability impacts regulators and businesses, particularly in the aviation industry, and facilitates access to productive services and market linkages. Airport stakeholders are increasingly pressuring companies to consider their socioeconomic impacts and manage them sustainably and resiliently. Business is paramount to airport companies in this competitive and economically sensitive climate.
  • 1.2K
  • 15 Aug 2023
Topic Review
Deep Learning Approaches for Distance Estimation
Visual impairment (VI) is a significant public health concern that affects people of all ages and is caused by a range of factors, including age-related eye diseases, genetic disorders, injuries, and infections. Therefore, governments of different countries are attempting to design various assistive living facilities for individuals with visual impairments. Machine learning techniques have greatly improved object recognition accuracy in computer vision [8]. This has led to the development of sophisticated models that can recognize objects in complex environments. 
  • 1.2K
  • 16 Oct 2023
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